JUP junction plakoglobin [Homo sapiens (human)] - Gene

Summary

Official Symbol: JUPprovided by HGNC
Official Full Name: junction plakoglobinprovided by HGNC
Primary source: HGNC:HGNC:6207
See related: Ensembl:ENSG00000173801 MIM:173325
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DP3; PDGB; PKGB; CTNNG; DPIII
Summary: This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]
Expression: Broad expression in skin (RPKM 236.9), esophagus (RPKM 189.1) and 16 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 17q21.2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	17	NC_000017.11 (41754607..41786768, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (39910859..39942964, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NEDD9, E-cadherin and gamma-catenin proteins have roles in pancreatic ductal adenocarcinoma
Title: Immunohistochemical expression of NEDD9, E-cadherin and γ-catenin and their prognostic significance in pancreatic ductal adenocarcinoma (PDAC).
gamma-Catenin acts as a tumor suppressor through context-dependent mechanisms in colorectal cancer.
Title: γ-Catenin acts as a tumor suppressor through context-dependent mechanisms in colorectal cancer.
Data show that plakoglobin interacted with p53R175H and decreased beta-catenin protein levels.
Title: Plakoglobin restores tumor suppressor activity of p53<sup>R175H</sup> mutant by sequestering the oncogenic potential of β-catenin.
FBW7 cooperated with gamma-catenin to inhibit G2/M cell cycle transition and cell proliferation.
Title: FBW7 suppresses cell proliferation and G2/M cell cycle transition via promoting γ-catenin K63-linked ubiquitylation.
These results suggest that a major role of 14-3-3gamma in desmosome assembly is to transport PG to the cell border leading to the initiation of desmosome formation.
Title: Plakoglobin localization to the cell border restores desmosome function in cells lacking 14-3-3γ.
We showed that p53 and PG cooperatively reduced growth and acted synergistically to decrease cellular migration and invasion
Title: The physical interaction of p53 and plakoglobin is necessary for their synergistic inhibition of migration and invasion.
High plakoglobin expression is associated with lung adenocarcinoma.
Title: The expression of plakoglobin is a potential prognostic biomarker for patients with surgically resected lung adenocarcinoma.
Knockdown of GATA6 completely eliminated the effect of TCF1, while forced expression of GATA6 induced hESC differentiation
Title: β-catenin coordinates with Jup and the TCF1/GATA6 axis to regulate human embryonic stem cell fate.
Studies indicate that the small molecule ICG-001 selectively blocks the cAMP response element-binding (CREB) protein (CBP)/beta-catenin or gamma-catenin interaction.
Title: CBP/Catenin antagonists: Targeting LSCs' Achilles heel.
Plakoglobin maintains the integrity of vascular endothelial cell junctions and regulates VEGF-induced phosphorylation of VE-cadherin
Title: Plakoglobin maintains the integrity of vascular endothelial cell junctions and regulates VEGF-induced phosphorylation of VE-cadherin.

Submit: New GeneRIF Correction See all GeneRIFs (79)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Arrhythmogenic right ventricular cardiomyopathy, type 12 MedGen: C1969081 OMIM: 611528 GeneReviews: Arrhythmogenic Right Ventricular Cardiomyopathy	Compare labs
Naxos disease MedGen: C1832600 OMIM: 601214 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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Acute myeloid leukemia, organism-specific biosystem (from KEGG)
Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Acute myeloid leukemia, conserved biosystem (from KEGG)
Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Adherens junctions interactions, organism-specific biosystem (from REACTOME)
Adherens junctions interactions, organism-specific biosystemThe adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (...
Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
Arf6 trafficking events, organism-specific biosystem
Arf6 trafficking events
Arrhythmogenic Right Ventricular Cardiomyopathy, organism-specific biosystem (from WikiPathways)
Arrhythmogenic Right Ventricular Cardiomyopathy, organism-specific biosystemAdapted from KEGG: http://www.genome.jp/kegg/pathway/hsa/hsa05412.html
Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
Cell junction organization, organism-specific biosystem (from REACTOME)
Cell junction organization, organism-specific biosystem
Cell junction organization
Cell-Cell communication, organism-specific biosystem (from REACTOME)
Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
Cell-cell junction organization, organism-specific biosystem (from REACTOME)
Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
Corticotropin-releasing hormone signaling pathway, organism-specific biosystem (from WikiPathways)
Corticotropin-releasing hormone signaling pathway, organism-specific biosystemCorticotropin-releasing hormone (CRH) is a neuropeptide secreted abundantly in the paraventricular nucleus of the hypothalamus, amygdala, cerebral cortex and cerebellum in the central nervous system ...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
E-cadherin signaling in the nascent adherens junction, organism-specific biosystem (from Pathway Interaction Database)
E-cadherin signaling in the nascent adherens junction, organism-specific biosystem
E-cadherin signaling in the nascent adherens junction
Ectoderm Differentiation, organism-specific biosystem (from WikiPathways)
Ectoderm Differentiation, organism-specific biosystemModel depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
Formation of the cornified envelope, organism-specific biosystem (from REACTOME)
Formation of the cornified envelope, organism-specific biosystemAs keratinocytes progress towards the upper epidermis, they undergo a unique process of cell death termed cornification (Eckhart et al. 2013). This involves the crosslinking of keratinocyte proteins ...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Keratinization, organism-specific biosystem (from REACTOME)
Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...
Neutrophil degranulation, organism-specific biosystem (from REACTOME)
Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by VEGF, organism-specific biosystem (from REACTOME)
Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer
VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
VEGFR2 mediated vascular permeability, organism-specific biosystem (from REACTOME)
VEGFR2 mediated vascular permeability, organism-specific biosystemThe free radical nitric oxide (NO), produced by endothelial NO synthase (eNOS), is an important vasoactive substance in normal vascular biology and pathophysiology. It plays an important role in vasc...
Wnt/beta-catenin Signaling Pathway in Leukemia, organism-specific biosystem (from WikiPathways)
Wnt/beta-catenin Signaling Pathway in Leukemia, organism-specific biosystemThe Wnt/Beta-catenin pathway mediates the transcription of proteins important for maintenance and growth of hematopoietic stem cells. The inhibition of Wnt leads to protein degradation through Beta-C...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Jup (e-PCR), detects polymorphism
- UniSTS:143648

RH17679 (e-PCR)
- UniSTS:54645

G07167 (e-PCR)
- UniSTS:55163

JUP (e-PCR)
- UniSTS:44727

SHGC-30259 (e-PCR)
- UniSTS:80066

Homology

Homologs of the JUP gene: The JUP gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 185 organisms have orthologs with human gene JUP
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
alpha-catenin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
alpha-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
cadherin binding	HDA more info	PubMed
cadherin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	IC Inferred by Curator more info	PubMed
nuclear hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
protein kinase binding	IEA Inferred from Electronic Annotation more info
protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
structural constituent of cell wall	IC Inferred by Curator more info	PubMed
structural molecule activity	NAS Non-traceable Author Statement more info	PubMed
transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
adherens junction organization	TAS Traceable Author Statement more info
bundle of His cell-Purkinje myocyte adhesion involved in cell communication	IMP Inferred from Mutant Phenotype more info	PubMed
cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to indole-3-methanol	IDA Inferred from Direct Assay more info	PubMed
cornification	TAS Traceable Author Statement more info
cytoskeletal anchoring at plasma membrane	NAS Non-traceable Author Statement more info	PubMed
desmosome assembly	IDA Inferred from Direct Assay more info	PubMed
desmosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
detection of mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed
endothelial cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
keratinization	TAS Traceable Author Statement more info
negative regulation of blood vessel endothelial cell migration	IGI Inferred from Genetic Interaction more info	PubMed
neutrophil degranulation	TAS Traceable Author Statement more info
positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of canonical Wnt signaling pathway	IC Inferred by Curator more info	PubMed
positive regulation of cell-matrix adhesion	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein heterooligomerization	IEA Inferred from Electronic Annotation more info
protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
regulation of heart rate by cardiac conduction	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of ventricular cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Z disc	IEA Inferred from Electronic Annotation more info
actin cytoskeleton	IEA Inferred from Electronic Annotation more info
apicolateral plasma membrane	IEA Inferred from Electronic Annotation more info
catenin complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
catenin complex	IDA Inferred from Direct Assay more info	PubMed
cell-cell adherens junction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cell-cell adherens junction	IDA Inferred from Direct Assay more info	PubMed
cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
cornified envelope	TAS Traceable Author Statement more info
cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
cytosol	ISS Inferred from Sequence or Structural Similarity more info
desmosome	IDA Inferred from Direct Assay more info	PubMed
extracellular exosome	HDA more info	PubMed
extracellular region	TAS Traceable Author Statement more info
fascia adherens	IEA Inferred from Electronic Annotation more info
ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
focal adhesion	HDA more info	PubMed
gamma-catenin-TCF7L2 complex	IDA Inferred from Direct Assay more info	PubMed
NOT hemidesmosome	ISS Inferred from Sequence or Structural Similarity more info
intercalated disc	IDA Inferred from Direct Assay more info	PubMed
intermediate filament	IEA Inferred from Electronic Annotation more info
lateral plasma membrane	IEA Inferred from Electronic Annotation more info
nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
protein-DNA complex	IDA Inferred from Direct Assay more info	PubMed
specific granule lumen	TAS Traceable Author Statement more info
zonula adherens	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: junction plakoglobin

Names: catenin (cadherin-associated protein), gamma 80kDa; desmoplakin III; desmoplakin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009090.2 RefSeqGene

Range

5001..37106

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_401

mRNA and Protein(s)

NM_001352773.1 → NP_001339702.1 junction plakoglobin

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript. Variants 1-7 encode the same protein.

Source sequence(s)

AC109319

Consensus CDS

CCDS11407.1

Conserved Domains (3) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

cl27106
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional
NM_001352774.1 → NP_001339703.1 junction plakoglobin

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks alternate segments in the 5' and 3' UTR, compared to transcript variant 3. Variants 1-7 encode the same protein.

Source sequence(s)

AC109319

Consensus CDS

CCDS11407.1

Conserved Domains (3) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

cl27106
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional
NM_001352775.1 → NP_001339704.1 junction plakoglobin

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks alternate segments in the 5' and 3' UTR, compared to transcript variant 3. Variants 1-7 encode the same protein.

Source sequence(s)

AC109319

Consensus CDS

CCDS11407.1

Conserved Domains (3) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

cl27106
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional
NM_001352776.1 → NP_001339705.1 junction plakoglobin

Status: REVIEWED

Description

Transcript Variant: This variant (6) has multiple differences in the 5' and 3' UTR, compared to transcript variant 3. Variants 1-7 encode the same protein.

Source sequence(s)

AC109319

Consensus CDS

CCDS11407.1

Conserved Domains (3) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

cl27106
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional
NM_001352777.1 → NP_001339706.1 junction plakoglobin

Status: REVIEWED

Description

Transcript Variant: This variant (7) has a novel exon in the 5' UTR and lacks an alternate segment in the 3' UTR, compared to transcript variant 3. Variants 1-7 encode the same protein.

Source sequence(s)

AC109319

Consensus CDS

CCDS11407.1

Conserved Domains (3) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

cl27106
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional
NM_002230.4 → NP_002221.1 junction plakoglobin

See identical proteins and their annotated locations for NP_002221.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks an alternate segment in the 5' UTR, compared to transcript variant 3. Variants 1-7 encode the same protein.

Source sequence(s)

AC109319

Consensus CDS

CCDS11407.1

UniProtKB/Swiss-Prot

P14923

UniProtKB/TrEMBL

A0A0S2Z487

Related

ENSP00000377508.3, ENST00000393931.8

Conserved Domains (3) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

cl27106
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional
NM_021991.3 → NP_068831.1 junction plakoglobin

See identical proteins and their annotated locations for NP_068831.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate segment in the 3' UTR, compared to transcript variant 3. Variants 1-7 encode the same protein.

Source sequence(s)

AC109319

Consensus CDS

CCDS11407.1

UniProtKB/Swiss-Prot

P14923

UniProtKB/TrEMBL

A0A0S2Z487

Related

ENSP00000311113.5, ENST00000310706.9

Conserved Domains (3) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

cl27106
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p12 Primary Assembly

Range

41754607..41786768 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006721875.1 → XP_006721938.1 junction plakoglobin isoform X2

See identical proteins and their annotated locations for XP_006721938.1

UniProtKB/Swiss-Prot

P14923

UniProtKB/TrEMBL

A0A0S2Z487

Conserved Domains (3) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

cl27106
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional
XM_006721874.3 → XP_006721937.1 junction plakoglobin isoform X2

See identical proteins and their annotated locations for XP_006721937.1

UniProtKB/Swiss-Prot

P14923

UniProtKB/TrEMBL

A0A0S2Z487

Related

ENSP00000377507.1, ENST00000393930.5

Conserved Domains (3) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

cl27106
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional
XM_011524753.2 → XP_011523055.1 junction plakoglobin isoform X2

See identical proteins and their annotated locations for XP_011523055.1

UniProtKB/Swiss-Prot

P14923

UniProtKB/TrEMBL

A0A0S2Z487

Conserved Domains (3) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

cl27106
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional
XM_011524758.1 → XP_011523060.1 junction plakoglobin isoform X2

See identical proteins and their annotated locations for XP_011523060.1

UniProtKB/Swiss-Prot

P14923

UniProtKB/TrEMBL

A0A0S2Z487

Conserved Domains (3) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

cl27106
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional
XM_011524756.1 → XP_011523058.1 junction plakoglobin isoform X2

See identical proteins and their annotated locations for XP_011523058.1

UniProtKB/Swiss-Prot

P14923

UniProtKB/TrEMBL

A0A0S2Z487

Conserved Domains (3) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

cl27106
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional
XM_017024590.1 → XP_016880079.1 junction plakoglobin isoform X2

UniProtKB/Swiss-Prot

P14923

UniProtKB/TrEMBL

A0A0S2Z487

Conserved Domains (3) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

cl27106
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional
XM_017024588.2 → XP_016880077.1 junction plakoglobin isoform X1