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NACA2 nascent polypeptide associated complex subunit alpha 2 [ Homo sapiens (human) ]

Gene ID: 342538, updated on 17-Jun-2019

Summary

Official Symbol
NACA2provided by HGNC
Official Full Name
nascent polypeptide associated complex subunit alpha 2provided by HGNC
Primary source
HGNC:HGNC:23290
See related
Ensembl:ENSG00000253506 MIM:609274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANAC; NACAL
Orthologs

Genomic context

See NACA2 in Genome Data Viewer
Location:
17q23.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (61590421..61591219, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (59667794..59668563, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 82 Neighboring gene T-box transcription factor 4 Neighboring gene BRCA1 interacting protein C-terminal helicase 1 Neighboring gene VISTA enhancer hs778 Neighboring gene integrator complex subunit 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nascent polypeptide-associated complex alpha subunit 2 (NACA2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71999

Gene Ontology Provided by GOA

Process Evidence Code Pubs
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nascent polypeptide-associated complex IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nascent polypeptide-associated complex subunit alpha-2
Names
IgE autoantigen alpha-nascent polypeptide-associated complex
alpha-NAC protein
hom s 2.01 protein
nascent polypeptide associated complex alpha subunit 2
nascent polypeptide-associated complex, alpha polypeptide, 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199290.4NP_954984.1  nascent polypeptide-associated complex subunit alpha-2

    See identical proteins and their annotated locations for NP_954984.1

    Status: VALIDATED

    Source sequence(s)
    AC002994, BC062710
    Consensus CDS
    CCDS11630.1
    UniProtKB/Swiss-Prot
    Q9H009
    Related
    ENSP00000427802.1, ENST00000521764.2
    Conserved Domains (2) summary
    cd14415
    Location:174214
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    pfam01849
    Location:82128
    NAC; NAC domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    61590421..61591219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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