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ID2 inhibitor of DNA binding 2 [ Homo sapiens (human) ]

Gene ID: 3398, updated on 15-Apr-2019

Summary

Official Symbol
ID2provided by HGNC
Official Full Name
inhibitor of DNA binding 2provided by HGNC
Primary source
HGNC:HGNC:5361
See related
Ensembl:ENSG00000115738 MIM:600386
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIG8; ID2A; ID2H; bHLHb26
Summary
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in liver (RPKM 128.2), bone marrow (RPKM 111.2) and 24 other tissues See more
Orthologs

Genomic context

See ID2 in Genome Data Viewer
Location:
2p25.1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (8681983..8684453)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (8822113..8824583)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373411 Neighboring gene VISTA enhancer hs1527 Neighboring gene ID2 antisense RNA 1 Neighboring gene uncharacterized LOC107985849 Neighboring gene kinase D interacting substrate 220 Neighboring gene ADP ribosylation factor like GTPase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
NHGRI GWA Catalog
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26389

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Peyer's patch development IEA
Inferred from Electronic Annotation
more info
 
adipose tissue development IEA
Inferred from Electronic Annotation
more info
 
adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
bundle of His development IEA
Inferred from Electronic Annotation
more info
 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis involved in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
embryonic digestive tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
endodermal digestive tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
enucleate erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
epithelial cell differentiation involved in mammary gland alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
locomotor rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
mammary gland alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
mammary gland epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
membranous septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
metanephros development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
olfactory bulb development IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell cycle arrest ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of macrophage differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription involved in G1/S transition of mitotic cell cycle IC
Inferred by Curator
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
thigmotaxis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
DNA-binding protein inhibitor ID-2
Names
DNA-binding protein inhibitor ID2
cell growth-inhibiting gene 8
class B basic helix-loop-helix protein 26
helix-loop-helix protein ID2
inhibitor of DNA binding 2, HLH protein
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
inhibitor of differentiation 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002166.5NP_002157.2  DNA-binding protein inhibitor ID-2

    See identical proteins and their annotated locations for NP_002157.2

    Status: REVIEWED

    Source sequence(s)
    AC011747
    Consensus CDS
    CCDS1659.1
    UniProtKB/Swiss-Prot
    Q02363
    UniProtKB/TrEMBL
    Q53T66
    Related
    ENSP00000379585.1, ENST00000396290.2
    Conserved Domains (1) summary
    cd00083
    Location:3879
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    8681983..8684453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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