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ZAR1 zygote arrest 1 [ Homo sapiens (human) ]

Gene ID: 326340, updated on 17-Jun-2019

Summary

Official Symbol
ZAR1provided by HGNC
Official Full Name
zygote arrest 1provided by HGNC
Primary source
HGNC:HGNC:20436
See related
Ensembl:ENSG00000182223 MIM:607520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Z3CXXC6
Summary
This maternal effect gene is oocyte-specific and encodes a protein that is thought to function in the initiation of embryogenesis. A similar protein in mouse is required for female fertility. [provided by RefSeq, Jul 2013]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See ZAR1 in Genome Data Viewer
Location:
4p11
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (48490252..48499351)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (48492269..48496406)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SLAIN motif family member 2 Neighboring gene U6 snRNA-associated Sm-like protein LSm2 pseudogene Neighboring gene solute carrier family 10 member 4 Neighboring gene FRY like transcription coactivator Neighboring gene RNA, U5E small nuclear 3, pseudogene Neighboring gene OCIAD1 antisense RNA 1 Neighboring gene OCIA domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Preimplantation Embryo, organism-specific biosystem (from WikiPathways)
    Preimplantation Embryo, organism-specific biosystemThe source of this pathway is RNA-Seq data from single-cell pre-implantation embryos (Supplemental Table 1): http://www.nature.com/nsmb/journal/v20/n9/full/nsmb.2660.html Analysis options for runnin...

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zygote arrest protein 1
Names
oocyte-specific maternal effect factor
zinc finger, 3CxxC-type 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175619.3NP_783318.1  zygote arrest protein 1

    See identical proteins and their annotated locations for NP_783318.1

    Status: REVIEWED

    Source sequence(s)
    AC096952, AI217763, AY191416, BC136265
    Consensus CDS
    CCDS3483.1
    UniProtKB/Swiss-Prot
    Q86SH2
    UniProtKB/TrEMBL
    B9EG67
    Related
    ENSP00000329803.4, ENST00000327939.4
    Conserved Domains (1) summary
    pfam13695
    Location:325410
    zf-3CxxC; Zinc-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    48490252..48499351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002959728.1 RNA Sequence

  2. XR_925129.3 RNA Sequence

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