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APCS amyloid P component, serum [ Homo sapiens (human) ]

Gene ID: 325, updated on 27-Nov-2024

Summary

Official Symbol
APCSprovided by HGNC
Official Full Name
amyloid P component, serumprovided by HGNC
Primary source
HGNC:HGNC:584
See related
Ensembl:ENSG00000132703 MIM:104770; AllianceGenome:HGNC:584
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAP; PTX2; HEL-S-92n
Summary
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
Expression
Restricted expression toward liver (RPKM 651.4) See more
Orthologs
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Genomic context

See APCS in Genome Data Viewer
Location:
1q23.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159587826..159588865)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (158724891..158725930)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159557616..159558655)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene amyloid P component, serum pseudogene Neighboring gene olfactory receptor family 10 subfamily AE member 1 pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:159567451-159568650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159573465-159573966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159573967-159574466 Neighboring gene olfactory receptor family 10 subfamily J member 6 pseudogene Neighboring gene C-reactive protein pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC88159

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables complement component C1q complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables complement component C1q complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding TAS
Traceable Author Statement
more info
PubMed 
enables virion binding IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serum amyloid P-component
Names
9.5S alpha-1-glycoprotein
epididymis secretory sperm binding protein Li 92n
pentaxin-related
pentraxin-2
pentraxin-related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001639.4NP_001630.1  serum amyloid P-component precursor

    See identical proteins and their annotated locations for NP_001630.1

    Status: REVIEWED

    Source sequence(s)
    AL445528, BC007058, X04608
    Consensus CDS
    CCDS1186.1
    UniProtKB/Swiss-Prot
    P02743
    UniProtKB/TrEMBL
    V9HWP0
    Related
    ENSP00000255040.2, ENST00000255040.3
    Conserved Domains (1) summary
    pfam00354
    Location:26219
    Pentaxin; Pentaxin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    159587826..159588865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    158724891..158725930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)