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HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) [ Homo sapiens (human) ]

Gene ID: 3183, updated on 3-Mar-2019

Summary

Official Symbol
HNRNPCprovided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein C (C1/C2)provided by HGNC
Primary source
HGNC:HGNC:5035
See related
Ensembl:ENSG00000092199 MIM:164020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1; C2; HNRNP; HNRPC; SNRPC
Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 82.0), bone marrow (RPKM 78.3) and 25 other tissues See more
Orthologs

Genomic context

See HNRNPC in Genome Data Viewer
Location:
14q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (21209136..21269479, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21677295..21737638, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene myoneurin pseudogene Neighboring gene long intergenic non-protein coding RNA 641 Neighboring gene RPGR interacting protein 1 Neighboring gene mitochondrial ribosomal protein S17 pseudogene 6 Neighboring gene SPT16 homolog, facilitates chromatin remodeling subunit Neighboring gene uncharacterized LOC107984643

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein C (HNRNPC), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein C (HNRNPC), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein C (HNRNPC), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein C (HNRNPC), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein C (HNRNPC), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPC is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • Regulation of Telomerase, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Telomerase, organism-specific biosystem
    Regulation of Telomerase
  • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
    SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
  • SUMOylation, organism-specific biosystem (from REACTOME)
    SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
  • SUMOylation of RNA binding proteins, organism-specific biosystem (from REACTOME)
    SUMOylation of RNA binding proteins, organism-specific biosystemSUMOylation of RNA-binding proteins (Li et al. 2004, reviewed in Filosa et al. 2013) alters their interactions with nucleic acids and with proteins. Whereas SUMOylation of HNRNPC decreases its affini...
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104306, MGC105117, MGC117353, MGC131677

Gene Ontology Provided by GOA

Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region HDA PubMed 
membrane HDA PubMed 
nuclear chromatin HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex HDA PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
telomerase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoproteins C1/C2
Names
hnRNP C1/C2
nuclear ribonucleoprotein particle C1 protein
nuclear ribonucleoprotein particle C2 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029011.1 RefSeqGene

    Range
    5001..65344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001077442.1NP_001070910.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform a

    See identical proteins and their annotated locations for NP_001070910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode isoform a, also known as isoform C2.
    Source sequence(s)
    AB209527, AL135744, BC108658, DB449514
    Consensus CDS
    CCDS41915.1
    UniProtKB/Swiss-Prot
    P07910
    Related
    ENSP00000452276.1, ENST00000557201.5
    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  2. NM_001077443.1NP_001070911.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform b

    See identical proteins and their annotated locations for NP_001070911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame segment compared to variant 1. The resulting isoform (b, also known as isoform C1) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 4 both encode isoform b.
    Source sequence(s)
    AL135744, BC108658, DB449514
    Consensus CDS
    CCDS45079.1
    UniProtKB/Swiss-Prot
    P07910
    Related
    ENSP00000338095.6, ENST00000336053.10
    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  3. NM_004500.3NP_004491.2  heterogeneous nuclear ribonucleoproteins C1/C2 isoform b

    See identical proteins and their annotated locations for NP_004491.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (b, also known as isoform C1) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 4 both encode isoform b.
    Source sequence(s)
    AL135744, BC003394, DB449514
    Consensus CDS
    CCDS45079.1
    UniProtKB/Swiss-Prot
    P07910
    Related
    ENSP00000450544.1, ENST00000553300.5
    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  4. NM_031314.2NP_112604.2  heterogeneous nuclear ribonucleoproteins C1/C2 isoform a

    See identical proteins and their annotated locations for NP_112604.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a, also known as isoform C2). Variants 1 and 3 both encode isoform a.
    Source sequence(s)
    AB209527, AL135744, DB449514
    Consensus CDS
    CCDS41915.1
    UniProtKB/Swiss-Prot
    P07910
    Related
    ENSP00000451291.1, ENST00000554455.5
    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    21209136..21269479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536708.1XP_011535010.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

    See identical proteins and their annotated locations for XP_011535010.1

    UniProtKB/Swiss-Prot
    P07910
    Related
    ENSP00000450790.1, ENST00000555309.5
    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  2. XM_011536710.2XP_011535012.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

    See identical proteins and their annotated locations for XP_011535012.1

    UniProtKB/Swiss-Prot
    P07910
    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  3. XM_011536711.2XP_011535013.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

    See identical proteins and their annotated locations for XP_011535013.1

    UniProtKB/Swiss-Prot
    P07910
    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  4. XM_011536709.3XP_011535011.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

    See identical proteins and their annotated locations for XP_011535011.1

    UniProtKB/Swiss-Prot
    P07910
    Related
    ENSP00000404848.2, ENST00000420743.6
    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  5. XM_024449556.1XP_024305324.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

  6. XM_024449557.1XP_024305325.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

  7. XM_011536712.2XP_011535014.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

    See identical proteins and their annotated locations for XP_011535014.1

    UniProtKB/Swiss-Prot
    P07910
    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  8. XM_017021252.2XP_016876741.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

    UniProtKB/Swiss-Prot
    P07910
    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  9. XM_024449559.1XP_024305327.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  10. XM_006720125.3XP_006720188.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

    See identical proteins and their annotated locations for XP_006720188.1

    UniProtKB/Swiss-Prot
    P07910
    Related
    ENSP00000451176.1, ENST00000556897.5
    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  11. XM_017021253.2XP_016876742.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

    UniProtKB/Swiss-Prot
    P07910
    Related
    ENSP00000450725.1, ENST00000554969.5
    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  12. XM_024449558.1XP_024305326.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

    Related
    ENSP00000442816.1, ENST00000430246.6
    Conserved Domains (1) summary
    cd12603
    Location:1585
    RRM_hnRNPC; RNA recognition motif in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
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