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NT5C 5', 3'-nucleotidase, cytosolic [ Homo sapiens (human) ]

Gene ID: 30833, updated on 15-Apr-2019

Summary

Official Symbol
NT5Cprovided by HGNC
Official Full Name
5', 3'-nucleotidase, cytosolicprovided by HGNC
Primary source
HGNC:HGNC:17144
See related
Ensembl:ENSG00000125458 MIM:191720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DNT; cdN; DNT1; P5N2; PN-I; HEL74; PN-II; UMPH2; dNT-1
Summary
This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in colon (RPKM 12.8), spleen (RPKM 11.1) and 25 other tissues See more
Orthologs

Genomic context

See NT5C in Genome Data Viewer
Location:
17q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (75130225..75131965, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73126320..73127890, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 80, pseudogene Neighboring gene solute carrier family 16 member 5 Neighboring gene armadillo repeat containing 7 Neighboring gene uncharacterized LOC107985034 Neighboring gene Jupiter microtubule associated homolog 1 Neighboring gene small ubiquitin like modifier 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5'-nucleotidase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotidase activity IDA
Inferred from Direct Assay
more info
PubMed 
pyrimidine nucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
purine nucleotide catabolic process TAS
Traceable Author Statement
more info
 
pyrimidine deoxyribonucleotide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
pyrimidine nucleoside catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
5'(3')-deoxyribonucleotidase, cytosolic type
Names
5' nucleotidase, deoxy (pyrimidine), cytosolic type C
cytosolic 5',3'-pyrimidine nucleotidase
deoxy-5'-nucleotidase 1
epididymis luminal protein 74
epididymis secretory sperm binding protein
uridine 5'-monophosphate phosphohydrolase 2
uridine 5-prime monophosphate hydrolase 2
NP_001239306.1
NP_055410.1
XP_011523002.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252377.1NP_001239306.1  5'(3')-deoxyribonucleotidase, cytosolic type isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, and uses an alternate in-frame acceptor splice site at the 3' terminal exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AF154829, BG034032, BQ431723, BU627693
    UniProtKB/Swiss-Prot
    Q8TCD5
    Related
    ENSP00000462697.1, ENST00000578407.5
    Conserved Domains (1) summary
    cl21460
    Location:7132
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. NM_014595.3NP_055410.1  5'(3')-deoxyribonucleotidase, cytosolic type isoform 1

    See identical proteins and their annotated locations for NP_055410.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AF154829
    Consensus CDS
    CCDS11715.1
    UniProtKB/Swiss-Prot
    Q8TCD5
    UniProtKB/TrEMBL
    V9HWF3
    Related
    ENSP00000245552.2, ENST00000245552.7
    Conserved Domains (1) summary
    cd02587
    Location:5168
    HAD_5-3dNT; 5'(3')-deoxyribonucleotidase

RNA

  1. NR_045513.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses alternate acceptor and donor splice sites at an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most supported translational start codon as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF154829, BC008183, BQ431723, BU627693
    Related
    ENST00000580758.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    75130225..75131965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524700.2XP_011523002.2  5'(3')-deoxyribonucleotidase, cytosolic type isoform X1

RNA

  1. XR_429885.3 RNA Sequence

  2. XR_002957995.1 RNA Sequence

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