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GSTP1 glutathione S-transferase pi 1 [ Homo sapiens (human) ]

Gene ID: 2950, updated on 17-Sep-2024

Summary

Official Symbol
GSTP1provided by HGNC
Official Full Name
glutathione S-transferase pi 1provided by HGNC
Primary source
HGNC:HGNC:4638
See related
Ensembl:ENSG00000084207 MIM:134660; AllianceGenome:HGNC:4638
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22
Summary
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 400.7), thyroid (RPKM 188.1) and 24 other tissues See more
Orthologs
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Genomic context

See GSTP1 in Genome Data Viewer
Location:
11q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (67583812..67586653)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (67578501..67581343)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67351283..67354124)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3644 Neighboring gene cyclin dependent kinase 2 associated protein 2 Neighboring gene calcium binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67297117-67297895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67297896-67298673 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:67330455-67331654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5109 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:67351053-67351195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5110 Neighboring gene MPRA-validated peak1312 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5112 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:67370959-67371644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67372331-67373016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5114 Neighboring gene NDUFV1 divergent transcript Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:67379204-67380403 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of glutathione S-transferase pi 1 (GSTP1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables JUN kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables S-nitrosoglutathione binding IDA
Inferred from Direct Assay
more info
PubMed 
enables dinitrosyl-iron complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acid binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nitric oxide binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in central nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in common myeloid progenitor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glutathione derivative biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hepoxilin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of MAPK cascade NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of acute inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fibroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of leukocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of monocyte chemotactic protein-1 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of stress-activated MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IC
Inferred by Curator
more info
PubMed 
involved_in nitric oxide storage NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of superoxide anion generation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in prostaglandin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of stress-activated MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to reactive oxygen species ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of TRAF2-GSTP1 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 
located_in vesicle HDA PubMed 

General protein information

Preferred Names
glutathione S-transferase P
Names
GST class-pi
GSTP1-1
deafness, X-linked 7
epididymis secretory protein Li 22
fatty acid ethyl ester synthase III
NP_000843.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012075.1 RefSeqGene

    Range
    5001..8059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_723

mRNA and Protein(s)

  1. NM_000852.4NP_000843.1  glutathione S-transferase P

    See identical proteins and their annotated locations for NP_000843.1

    Status: REVIEWED

    Source sequence(s)
    BC010915, X15480
    Consensus CDS
    CCDS41679.1
    UniProtKB/Swiss-Prot
    O00460, P09211, Q15690, Q5TZY3
    UniProtKB/TrEMBL
    A8MX94, V9HWE9
    Related
    ENSP00000381607.3, ENST00000398606.10
    Conserved Domains (2) summary
    cd03210
    Location:84210
    GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases
    cd03076
    Location:376
    GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    67583812..67586653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    67578501..67581343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)