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TBK1 TANK binding kinase 1 [ Homo sapiens (human) ]

Gene ID: 29110, updated on 27-May-2024

Summary

Official Symbol
TBK1provided by HGNC
Official Full Name
TANK binding kinase 1provided by HGNC
Primary source
HGNC:HGNC:11584
See related
Ensembl:ENSG00000183735 MIM:604834; AllianceGenome:HGNC:11584
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAK; T2K; IIAE8; FTDALS4
Summary
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in testis (RPKM 15.8), bone marrow (RPKM 10.3) and 25 other tissues See more
Orthologs
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Genomic context

See TBK1 in Genome Data Viewer
Location:
12q14.2
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (64452120..64502114)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (64430747..64480735)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (64845900..64895894)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6592 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:64798894-64799770 Neighboring gene ribosomal protein S11 pseudogene 6 Neighboring gene exportin for tRNA Neighboring gene MPRA-validated peak1761 silencer Neighboring gene mitochondrial ribosomal protein S25 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6593 Neighboring gene uncharacterized LOC105369803 Neighboring gene Ras association domain family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6594 Neighboring gene small nucleolar RNA SNORD83

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif co-immunoprecipitates with TBK1 suggesting an interaction between Vif and TBK1 PubMed
Vpr vpr HIV-1 Vpr co-immunoprecipitates with TBK1 suggesting an interaction between Vpr and TBK1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ11330

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antiviral innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cGAS/STING signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in canonical NF-kappaB signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in cytoplasmic pattern recognition receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to virus NAS
Non-traceable Author Statement
more info
PubMed 
involved_in dendritic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of interferon-alpha production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type I interferon production TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of xenophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to virus TAS
Traceable Author Statement
more info
PubMed 
involved_in toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in type I interferon-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of serine/threonine protein kinase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase TBK1
Names
NF-kB-activating kinase
NF-kappa-B-activating kinase
NP_037386.1
XP_005268866.1
XP_005268867.1
XP_054227832.1
XP_054227833.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046906.1 RefSeqGene

    Range
    5061..55055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1306

mRNA and Protein(s)

  1. NM_013254.4NP_037386.1  serine/threonine-protein kinase TBK1

    See identical proteins and their annotated locations for NP_037386.1

    Status: REVIEWED

    Source sequence(s)
    AA970899, AC135279, AC136977, BC034950
    Consensus CDS
    CCDS8968.1
    UniProtKB/Swiss-Prot
    A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
    UniProtKB/TrEMBL
    A0A7I2V646
    Related
    ENSP00000329967.5, ENST00000331710.10
    Conserved Domains (3) summary
    smart00220
    Location:9242
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd12219
    Location:297385
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cd13988
    Location:15330
    STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    64452120..64502114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268810.2XP_005268867.1  serine/threonine-protein kinase TBK1 isoform X1

    See identical proteins and their annotated locations for XP_005268867.1

    UniProtKB/Swiss-Prot
    A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
    UniProtKB/TrEMBL
    A0A7I2V646
    Conserved Domains (3) summary
    smart00220
    Location:9242
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd12219
    Location:297385
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cd13988
    Location:15330
    STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1
  2. XM_005268809.2XP_005268866.1  serine/threonine-protein kinase TBK1 isoform X1

    See identical proteins and their annotated locations for XP_005268866.1

    UniProtKB/Swiss-Prot
    A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
    UniProtKB/TrEMBL
    A0A7I2V646
    Conserved Domains (3) summary
    smart00220
    Location:9242
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd12219
    Location:297385
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cd13988
    Location:15330
    STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1

RNA

  1. XR_007063071.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    64430747..64480735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371858.1XP_054227833.1  serine/threonine-protein kinase TBK1 isoform X1

    UniProtKB/Swiss-Prot
    A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
  2. XM_054371857.1XP_054227832.1  serine/threonine-protein kinase TBK1 isoform X1

    UniProtKB/Swiss-Prot
    A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2

RNA

  1. XR_008488571.1 RNA Sequence