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GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 [ Homo sapiens (human) ]

Gene ID: 2907, updated on 15-Apr-2019

Summary

Official Symbol
GRINAprovided by HGNC
Official Full Name
glutamate ionotropic receptor NMDA type subunit associated protein 1provided by HGNC
Primary source
HGNC:HGNC:4589
See related
Ensembl:ENSG00000178719 MIM:138251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LFG1; HNRGW; TMBIM3; NMDARA1
Expression
Ubiquitous expression in fat (RPKM 80.7), brain (RPKM 68.3) and 25 other tissues See more
Orthologs

Genomic context

See GRINA in Genome Data Viewer
Location:
8q24.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (143990058..143993415)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145064226..145067596)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene plectin Neighboring gene microRNA 661 Neighboring gene poly(ADP-ribose) polymerase family member 10 Neighboring gene spermatogenesis and centriole associated 1 Neighboring gene sphingomyelin phosphodiesterase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (GRINA) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
env HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed
env HIV-1 gp120 binds to cells expressing epsilon1/zeta1 or epsilon2/zeta1 combined NMDA receptor subunits, but not to cells expressing a single epsilon1, epsilon2, or zeta1 NMDA receptor subunit PubMed
env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120-mediated human cell death involves the NMDA receptor complex; antagonists of the NMDA receptor reverse the gp120-mediated effects PubMed
Tat tat HIV-1 Tat binding to NMDA receptors results in subsequent loss of postsynaptic densities and an NMDA receptor antagonist inhibits this loss PubMed
tat HIV-1 Tat and methamphetamine inhibit the normal conjunction of signaling between D1 and NMDA receptors, resulting in neural dysfunction and death PubMed
tat HIV-1 Tat induces apoptosis of neurons and neurotoxicity through the activation of both NMDA and non-NMDA receptors PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99687

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein lifeguard 1
Names
NMDA receptor glutamate-binding subunit
glutamate [NMDA] receptor-associated protein 1
glutamate receptor, NMDA subtype, glutamate-binding subunit
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
putative MAPK-activating protein PM02
transmembrane BAX inhibitor motif containing 3
transmembrane BAX inhibitor motif-containing protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000837.1NP_000828.1  protein lifeguard 1

    See identical proteins and their annotated locations for NP_000828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC084553, BM762447, BQ682451
    Consensus CDS
    CCDS34961.1
    UniProtKB/Swiss-Prot
    Q7Z429
    Related
    ENSP00000314380.5, ENST00000313269.5
    Conserved Domains (2) summary
    cd10428
    Location:151367
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    pfam15240
    Location:39139
    Pro-rich; Proline-rich
  2. NM_001009184.2NP_001009184.1  protein lifeguard 1

    See identical proteins and their annotated locations for NP_001009184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC109322
    Consensus CDS
    CCDS34961.1
    UniProtKB/Swiss-Prot
    Q7Z429
    Related
    ENSP00000378507.4, ENST00000395068.9
    Conserved Domains (2) summary
    cd10428
    Location:151367
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    pfam15240
    Location:39139
    Pro-rich; Proline-rich

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    143990058..143993415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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