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GRK4 G protein-coupled receptor kinase 4 [ Homo sapiens (human) ]

Gene ID: 2868, updated on 17-Jun-2019

Summary

Official Symbol
GRK4provided by HGNC
Official Full Name
G protein-coupled receptor kinase 4provided by HGNC
Primary source
HGNC:HGNC:4543
See related
Ensembl:ENSG00000125388 MIM:137026
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IT11; GPRK4; GRK4a; GPRK2L
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Expression
Biased expression in testis (RPKM 14.6) and brain (RPKM 0.7) See more
Orthologs

Genomic context

See GRK4 in Genome Data Viewer
Location:
4p16.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (2963504..3040760)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2965232..3042474)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NOP14 antisense RNA 1 Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene NOP14 nucleolar protein Neighboring gene RNA, U6 small nuclear 204, pseudogene Neighboring gene HTT antisense RNA

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystem (from REACTOME)
    Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystemTo terminate the single photon response and restore the system to its basal state, the three activated intermediates in phototransduction, rhodopsin (MII), transducin alpha subunit with GTP bound (GN...
  • Morphine addiction, organism-specific biosystem (from KEGG)
    Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Morphine addiction, conserved biosystem (from KEGG)
    Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • The phototransduction cascade, organism-specific biosystem (from REACTOME)
    The phototransduction cascade, organism-specific biosystemThe visual pigment (rhodopsin in rods) consists of an 11-cis-retinal (11cRAL) chromophore covalently attached to a GPCR opsin family member via a Schiff base linkage. Upon photon absorption, 11cRAL i...
  • Visual phototransduction, organism-specific biosystem (from REACTOME)
    Visual phototransduction, organism-specific biosystemVisual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are p...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
rhodopsin kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor internalization IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of rhodopsin mediated signaling pathway TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
photoreceptor disc membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G protein-coupled receptor kinase 4
Names
G protein-coupled receptor kinase 2-like
NP_001004056.1
NP_001004057.1
NP_001337102.1
NP_005298.2
NP_892027.2
XP_005248019.1
XP_006713943.1
XP_011511749.1
XP_011511750.1
XP_011511751.1
XP_011511752.1
XP_011511753.1
XP_011511754.1
XP_011511755.1
XP_011511756.1
XP_011511757.1
XP_011511758.1
XP_011511759.1
XP_016863541.1
XP_016863542.1
XP_016863543.1
XP_016863544.1
XP_016863545.1
XP_016863546.1
XP_016863547.1
XP_016863548.1
XP_016863551.1
XP_016863552.1
XP_016863553.1
XP_016863554.1
XP_016863555.1
XP_024309783.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029102.1 RefSeqGene

    Range
    5001..82132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004056.2NP_001004056.1  G protein-coupled receptor kinase 4 isoform beta

    See identical proteins and their annotated locations for NP_001004056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (beta) has the same N- and C-termini but is shorter compared to isoform alpha.
    Source sequence(s)
    AL390065, BC027597, BI465220, BM725978, U33054
    Consensus CDS
    CCDS47002.1
    UniProtKB/Swiss-Prot
    P32298
    Related
    ENSP00000264764.8, ENST00000345167.10
    Conserved Domains (3) summary
    cd05631
    Location:154438
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:155417
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:20152
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. NM_001004057.2NP_001004057.1  G protein-coupled receptor kinase 4 isoform gamma

    See identical proteins and their annotated locations for NP_001004057.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (gamma) has the same N- and C-termini but is shorter compared to isoform alpha.
    Source sequence(s)
    AL390065, BC027597, BI465220, BM725978
    Consensus CDS
    CCDS33947.1
    UniProtKB/Swiss-Prot
    P32298
    Related
    ENSP00000427445.1, ENST00000504933.1
    Conserved Domains (3) summary
    cd05631
    Location:186470
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:187449
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  3. NM_001350173.2NP_001337102.1  G protein-coupled receptor kinase 4 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 5, which has a shorter and distinct N-terminus, compared to isoform alpha.
    Source sequence(s)
    AK223581, AK292390, AL390065, BI792406, N23898, X97881
    Conserved Domains (1) summary
    cl21453
    Location:5276
    PKc_like; Protein Kinases, catalytic domain
  4. NM_005307.3NP_005298.2  G protein-coupled receptor kinase 4 isoform delta

    See identical proteins and their annotated locations for NP_005298.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (delta) has the same N- and C-termini but is shorter compared to isoform alpha.
    Source sequence(s)
    AK223581, AL390065, X97879
    Consensus CDS
    CCDS68656.1
    UniProtKB/Swiss-Prot
    P32298
    Related
    ENSP00000381128.4, ENST00000398051.8
    Conserved Domains (3) summary
    cd05631
    Location:154438
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:155417
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:20152
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  5. NM_182982.3NP_892027.2  G protein-coupled receptor kinase 4 isoform alpha

    See identical proteins and their annotated locations for NP_892027.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (alpha).
    Source sequence(s)
    AL390065, BC027597, BI465220, BM725978, U33054
    Consensus CDS
    CCDS33946.1
    UniProtKB/Swiss-Prot
    P32298
    Related
    ENSP00000381129.4, ENST00000398052.9
    Conserved Domains (3) summary
    cd05631
    Location:186470
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:187449
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    2963504..3040760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513447.2XP_011511749.1  G protein-coupled receptor kinase 4 isoform X1

    Conserved Domains (3) summary
    cd05631
    Location:186509
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:187488
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. XM_017008053.1XP_016863542.1  G protein-coupled receptor kinase 4 isoform X4

  3. XM_017008052.1XP_016863541.1  G protein-coupled receptor kinase 4 isoform X3

  4. XM_011513449.2XP_011511751.1  G protein-coupled receptor kinase 4 isoform X5

    Conserved Domains (3) summary
    cd05631
    Location:154477
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:155456
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:20152
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  5. XM_011513450.2XP_011511752.1  G protein-coupled receptor kinase 4 isoform X6

    Conserved Domains (3) summary
    cd05631
    Location:186509
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:187488
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  6. XM_011513453.2XP_011511755.1  G protein-coupled receptor kinase 4 isoform X9

    Conserved Domains (3) summary
    smart00220
    Location:187488
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:186508
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011513451.2XP_011511753.1  G protein-coupled receptor kinase 4 isoform X7

    Conserved Domains (3) summary
    smart00220
    Location:187462
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:186470
    PKc_like; Protein Kinases, catalytic domain
  8. XM_011513454.2XP_011511756.1  G protein-coupled receptor kinase 4 isoform X10

    Conserved Domains (3) summary
    smart00220
    Location:187462
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:186470
    PKc_like; Protein Kinases, catalytic domain
  9. XM_011513455.2XP_011511757.1  G protein-coupled receptor kinase 4 isoform X12

    Conserved Domains (3) summary
    smart00220
    Location:187471
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:186472
    PKc_like; Protein Kinases, catalytic domain
  10. XM_011513456.2XP_011511758.1  G protein-coupled receptor kinase 4 isoform X15

    Conserved Domains (2) summary
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:186363
    PKc_like; Protein Kinases, catalytic domain
  11. XM_017008065.1XP_016863554.1  G protein-coupled receptor kinase 4 isoform X21

  12. XM_017008054.1XP_016863543.1  G protein-coupled receptor kinase 4 isoform X11

  13. XM_017008056.1XP_016863545.1  G protein-coupled receptor kinase 4 isoform X14

  14. XM_017008055.1XP_016863544.1  G protein-coupled receptor kinase 4 isoform X13

  15. XM_011513452.2XP_011511754.1  G protein-coupled receptor kinase 4 isoform X8

    Conserved Domains (3) summary
    cd08750
    Location:52184
    RGS_GRK4; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4)
    smart00220
    Location:187462
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:186470
    PKc_like; Protein Kinases, catalytic domain
  16. XM_011513448.2XP_011511750.1  G protein-coupled receptor kinase 4 isoform X2

    Conserved Domains (3) summary
    cd05631
    Location:186509
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    cd08750
    Location:52184
    RGS_GRK4; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4)
    smart00220
    Location:187488
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  17. XM_011513457.2XP_011511759.1  G protein-coupled receptor kinase 4 isoform X20

    Conserved Domains (2) summary
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:186286
    PKc_like; Protein Kinases, catalytic domain
  18. XM_017008062.1XP_016863551.1  G protein-coupled receptor kinase 4 isoform X17

    Conserved Domains (2) summary
    smart00220
    Location:20238
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1259
    PKc_like; Protein Kinases, catalytic domain
  19. XM_017008059.2XP_016863548.1  G protein-coupled receptor kinase 4 isoform X16

    Conserved Domains (1) summary
    cl21453
    Location:5276
    PKc_like; Protein Kinases, catalytic domain
  20. XM_005247962.3XP_005248019.1  G protein-coupled receptor kinase 4 isoform X17

    See identical proteins and their annotated locations for XP_005248019.1

    Conserved Domains (2) summary
    smart00220
    Location:20238
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1259
    PKc_like; Protein Kinases, catalytic domain
  21. XM_017008064.1XP_016863553.1  G protein-coupled receptor kinase 4 isoform X19

  22. XM_017008058.1XP_016863547.1  G protein-coupled receptor kinase 4 isoform X16

    Conserved Domains (1) summary
    cl21453
    Location:5276
    PKc_like; Protein Kinases, catalytic domain
  23. XM_006713880.3XP_006713943.1  G protein-coupled receptor kinase 4 isoform X17

    See identical proteins and their annotated locations for XP_006713943.1

    Conserved Domains (2) summary
    smart00220
    Location:20238
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1259
    PKc_like; Protein Kinases, catalytic domain
  24. XM_017008066.1XP_016863555.1  G protein-coupled receptor kinase 4 isoform X22

  25. XM_024454015.1XP_024309783.1  G protein-coupled receptor kinase 4 isoform X16

    Conserved Domains (1) summary
    cl21453
    Location:5276
    PKc_like; Protein Kinases, catalytic domain
  26. XM_017008057.1XP_016863546.1  G protein-coupled receptor kinase 4 isoform X16

    Conserved Domains (1) summary
    cl21453
    Location:5276
    PKc_like; Protein Kinases, catalytic domain
  27. XM_017008063.1XP_016863552.1  G protein-coupled receptor kinase 4 isoform X18

RNA

  1. XR_001741211.1 RNA Sequence

  2. XR_924943.2 RNA Sequence

  3. XR_924941.2 RNA Sequence

  4. XR_001741210.1 RNA Sequence

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