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CXCR3 C-X-C motif chemokine receptor 3 [ Homo sapiens (human) ]

Gene ID: 2833, updated on 21-Apr-2019

Summary

Official Symbol
CXCR3provided by HGNC
Official Full Name
C-X-C motif chemokine receptor 3provided by HGNC
Primary source
HGNC:HGNC:4540
See related
Ensembl:ENSG00000186810 MIM:300574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
Summary
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
Expression
Biased expression in lymph node (RPKM 6.3), spleen (RPKM 3.4) and 13 other tissues See more
Orthologs

Genomic context

See CXCR3 in Genome Data Viewer
Location:
Xq13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (71615913..71618517, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70835766..70838367, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase Neighboring gene germ cell nuclear acidic peptidase Neighboring gene chromosome X open reading frame 49 pseudogene Neighboring gene chromosome X open reading frame 49-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The interaction of CXCR4 with HIV-1 gp120 mediates gp120-induced upregulation of the CXCR3 and EMAP2 expression in human lung microvascular endothelial cells PubMed
env HIV-1 gp120-induced upregulation of CXCR3 and EMAP2 expression and apoptosis requires activation of p38 MAPK in human lung microvascular endothelial cells PubMed
Nef nef HIV-1 Nef induces variable levels of CXCR3 downregulation in different cell types PubMed
nef Significant increases in neuronal cell death resulting from HIV-1 Nef-induced upregulation of IP-10 is reduced by an antibody directed against human CXCR3, suggesting an interaction of CXCR3 with Nef PubMed
Tat tat HIV-1 Tat can inhibit CXCR3-mediated functions by interfering with the chemotactic activity of IP-10/CXCL10, an effect mediated by Tat amino acids 25-31 PubMed
Vif vif HIV-1 Vif upregulates the expression of chemokine (C-X-C motif) receptor 3 (CXCR3) in Vif-expression T cells PubMed
Vpu vpu HIV-1 Vpu downregulates the cell surface expression of chemokine (C-X-C motif) receptor 3 (CXCR3, CD183) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • CXCR3-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    CXCR3-mediated signaling events, organism-specific biosystem
    CXCR3-mediated signaling events
  • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
    Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-X-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
chemokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
chemokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C-X-C chemokine receptor type 3
Names
G protein-coupled receptor 9
IP-10 receptor
Mig receptor
chemokine (C-X-C motif) receptor 3
chemokine receptor 3
interferon-inducible protein 10 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029076.1 RefSeqGene

    Range
    5001..7602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142797.1NP_001136269.1  C-X-C chemokine receptor type 3 isoform 2

    See identical proteins and their annotated locations for NP_001136269.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in an isoform (2, also known as CXCR3-B) with a longer and distinct N-terminus compared to isoform 1. This isoform acts as functional receptor for chemokine CXCL4/PF4 (PMID:12782716).
    Source sequence(s)
    AF469635, X95876
    Consensus CDS
    CCDS48135.1
    UniProtKB/Swiss-Prot
    P49682
    Related
    ENSP00000362795.4, ENST00000373691.4
    Conserved Domains (1) summary
    cd15180
    Location:101376
    7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001504.2NP_001495.1  C-X-C chemokine receptor type 3 isoform 1

    See identical proteins and their annotated locations for NP_001495.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as CXCR3-A). This isoform functions as a receptor for chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC (PMID:12782716).
    Source sequence(s)
    X95876
    Consensus CDS
    CCDS14416.1
    UniProtKB/Swiss-Prot
    P49682
    Related
    ENSP00000362797.3, ENST00000373693.4
    Conserved Domains (1) summary
    cd15180
    Location:54329
    7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    71615913..71618517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029436.1XP_016884925.1  C-X-C chemokine receptor type 3 isoform X4

  2. XM_005262257.3XP_005262314.1  C-X-C chemokine receptor type 3 isoform X3

    Conserved Domains (1) summary
    pfam00001
    Location:84218
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_005262256.3XP_005262313.1  C-X-C chemokine receptor type 3 isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:84328
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_017029435.1XP_016884924.1  C-X-C chemokine receptor type 3 isoform X1

    UniProtKB/Swiss-Prot
    P49682
    Conserved Domains (1) summary
    cd15180
    Location:101376
    7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors
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