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NPBWR1 neuropeptides B and W receptor 1 [ Homo sapiens (human) ]

Gene ID: 2831, updated on 27-Nov-2024

Summary

Official Symbol
NPBWR1provided by HGNC
Official Full Name
neuropeptides B and W receptor 1provided by HGNC
Primary source
HGNC:HGNC:4522
See related
Ensembl:ENSG00000288611 MIM:600730; AllianceGenome:HGNC:4522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR7
Summary
Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See NPBWR1 in Genome Data Viewer
Location:
8q11.23
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (52939182..52943734)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (53315605..53320157)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (53851742..53856294)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375835 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:53676283-53677482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27349 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:53764919-53765152 Neighboring gene uncharacterized LOC107986943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:53851917-53852548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:53852549-53853180 Neighboring gene NANOG hESC enhancer GRCh37_chr8:53883082-53883583 Neighboring gene E3 ubiquitin-protein ligase RING2-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:53930926-53931660 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:53931661-53932394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27350 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:54055436-54056635 Neighboring gene uncharacterized LOC105375836 Neighboring gene EI24 pseudogene 5

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC129755

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled opioid receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropeptide receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled opioid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IC
Inferred by Curator
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neuropeptides B/W receptor type 1
Names
G-protein coupled receptor 7
neuropeptide B/W receptor 1
neuropeptides B/W receptor 1
opioid-somatostatin-like receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005285.5NP_005276.2  neuropeptides B/W receptor type 1

    See identical proteins and their annotated locations for NP_005276.2

    Status: VALIDATED

    Source sequence(s)
    AC087348
    Consensus CDS
    CCDS6151.1
    UniProtKB/Swiss-Prot
    P48145, Q6NTC7
    UniProtKB/TrEMBL
    H9NIL7
    Related
    ENSP00000501711.1, ENST00000674939.1
    Conserved Domains (1) summary
    cd15087
    Location:47318
    7tmA_NPBWR; neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    52939182..52943734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    53315605..53320157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)