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SFN stratifin [ Homo sapiens (human) ]

Gene ID: 2810, updated on 5-May-2024

Summary

Official Symbol
SFNprovided by HGNC
Official Full Name
stratifinprovided by HGNC
Primary source
HGNC:HGNC:10773
See related
Ensembl:ENSG00000175793 MIM:601290; AllianceGenome:HGNC:10773
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YWHAS
Summary
This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017]
Orthologs
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Genomic context

See SFN in Genome Data Viewer
Location:
1p36.11
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26863149..26864456)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (26701224..26702527)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27189640..27190947)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 165, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:27152961-27153113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 523 Neighboring gene zinc finger DHHC-type palmitoyltransferase 18 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 525 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27179723-27180224 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:27181471-27181643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27189325-27190204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 527 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:27195686-27195844 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:27198339-27199538 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27201365-27201864 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27215935-27216812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 529 Neighboring gene GPN-loop GTPase 2 Neighboring gene G-patch domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 530 Neighboring gene nuclear distribution C, dynein complex regulator

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphoserine residue binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein sequestering activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in establishment of skin barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of epidermal cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in protein kinase A signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of epidermal cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular space TAS
Traceable Author Statement
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
14-3-3 protein sigma
Names
epithelial cell marker protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006142.5NP_006133.1  14-3-3 protein sigma

    See identical proteins and their annotated locations for NP_006133.1

    Status: REVIEWED

    Source sequence(s)
    BC001550, BC023552
    Consensus CDS
    CCDS288.1
    UniProtKB/Swiss-Prot
    P31947, Q6FH30, Q6FH51, Q96DH0
    Related
    ENSP00000340989.4, ENST00000339276.6
    Conserved Domains (1) summary
    cd10019
    Location:1242
    14-3-3_sigma; 14-3-3 sigma, an isoform of 14-3-3 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    26863149..26864456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    26701224..26702527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)