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CRCP CGRP receptor component [ Homo sapiens (human) ]

Gene ID: 27297, updated on 13-Feb-2019

Summary

Official Symbol
CRCPprovided by HGNC
Official Full Name
CGRP receptor componentprovided by HGNC
Primary source
HGNC:HGNC:17888
See related
Ensembl:ENSG00000241258 MIM:606121
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RCP; RCP9; RPC9; CGRPRCP; CGRP-RCP
Summary
This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 11.5), thyroid (RPKM 11.3) and 25 other tissues See more
Orthologs

Genomic context

See CRCP in Genome Data Viewer
Location:
7q11.21
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (66114818..66154568)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (65579805..65619555)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene golgin A7 pseudogene Neighboring gene argininosuccinate lyase Neighboring gene tyrosylprotein sulfotransferase 1 Neighboring gene RNA, U6 small nuclear 313, pseudogene Neighboring gene long intergenic non-protein coding RNA 174

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111194

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-directed 5'-3' RNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcitonin gene-related peptide receptor activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
PubMed 
transcription initiation from RNA polymerase III promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
DNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
cell IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase III subunit RPC9
Names
CGRP-receptor component protein
RNA polymerase III subunit C9
calcitonin gene-related peptide-receptor component protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040647.1NP_001035737.1  DNA-directed RNA polymerase III subunit RPC9 isoform b

    See identical proteins and their annotated locations for NP_001035737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC068533, BC040107, BC052570, BI600330
    Consensus CDS
    CCDS47599.1
    UniProtKB/Swiss-Prot
    O75575
    Related
    ENSP00000340044.5, ENST00000338592.5
    Conserved Domains (1) summary
    cl00638
    Location:1494
    RNA_pol_Rpb4; RNA polymerase Rpb4
  2. NM_001040648.1NP_001035738.1  DNA-directed RNA polymerase III subunit RPC9 isoform c

    See identical proteins and their annotated locations for NP_001035738.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three consecutive exons but maintains the reading frame, compared to variant 1, resulting in a much shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AC068533, BC052570, BI600330, DB472426
    Consensus CDS
    CCDS47600.1
    UniProtKB/Swiss-Prot
    O75575
    Related
    ENSP00000381674.2, ENST00000398684.6
    Conserved Domains (1) summary
    cl00638
    Location:450
    RNA_pol_Rpb4; RNA polymerase Rpb4
  3. NM_001142414.1NP_001135886.1  DNA-directed RNA polymerase III subunit RPC9 isoform d

    See identical proteins and their annotated locations for NP_001135886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal segment in the 5' region, which results in an upstream AUG start codon, and also lacks an exon in the middle region, as compared to variant 1. The reading frame is not affected, and the resulting isoform (d) is shorter and has a distinct N-terminus, as compared to isoform a.
    Source sequence(s)
    AC068533, AK303737, DA821665
    Consensus CDS
    CCDS55116.1
    UniProtKB/Swiss-Prot
    O75575
    Related
    ENSP00000388653.2, ENST00000431089.6
    Conserved Domains (1) summary
    cl00638
    Location:40120
    RNA_pol_Rpb4; RNA polymerase Rpb4
  4. NM_014478.5NP_055293.1  DNA-directed RNA polymerase III subunit RPC9 isoform a

    See identical proteins and their annotated locations for NP_055293.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC068533, BC052570, BC105808, BI600330, U51134
    Consensus CDS
    CCDS5532.1
    UniProtKB/Swiss-Prot
    O75575
    UniProtKB/TrEMBL
    A0A024RDL0
    Related
    ENSP00000378736.3, ENST00000395326.7
    Conserved Domains (1) summary
    smart00657
    Location:1127
    RPOL4c; DNA-directed RNA-polymerase II subunit

RNA

  1. NR_024548.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an additional exon in the coding region, which includes a translation stop codon, as compared to variant 1. This transcript is therefore a nonsense-mediated mRNA decay (NMD) candidate, and does not make a functional protein.
    Source sequence(s)
    AC068533, BC052570, DA955978
    Related
    ENST00000360415.7

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    66114818..66154568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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