Format

Send to:

Choose Destination

NMRK2 nicotinamide riboside kinase 2 [ Homo sapiens (human) ]

Gene ID: 27231, updated on 13-Feb-2019

Summary

Official Symbol
NMRK2provided by HGNC
Official Full Name
nicotinamide riboside kinase 2provided by HGNC
Primary source
HGNC:HGNC:17871
See related
Ensembl:ENSG00000077009 MIM:608705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIBP; NRK2; ITGB1BP3
Expression
Restricted expression toward heart (RPKM 167.4) See more
Orthologs

Genomic context

See NMRK2 in Genome Data Viewer
Location:
19p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (3933103..3942416)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3933101..3942414)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ferritin light chain pseudogene 5 Neighboring gene ATCAY kinesin light chain interacting caytaxin Neighboring gene RNA, 7SL, cytoplasmic 202, pseudogene Neighboring gene death associated protein kinase 3 Neighboring gene microRNA 637 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene small nucleolar RNA, C/D box 37

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126624

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosylnicotinamide kinase activity EXP
Inferred from Experiment
more info
PubMed 
ribosylnicotinate kinase activity EXP
Inferred from Experiment
more info
PubMed 
Process Evidence Code Pubs
NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
NAD metabolic process TAS
Traceable Author Statement
more info
 
negative regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nicotinamide riboside kinase 2
Names
NRK 2
RNK 2
integrin beta-1-binding protein 3
muscle-specific beta 1 integrin binding protein
nicotinic acid riboside kinase 2
nmR-K 2
ribosylnicotinamide kinase 2
ribosylnicotinic acid kinase 2
NP_001276046.1
NP_733778.1
XP_006722788.1
XP_006722789.1
XP_016882086.1
XP_024307220.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289117.1NP_001276046.1  nicotinamide riboside kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_001276046.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK001663, BC143329, BM669267
    Consensus CDS
    CCDS74259.1
    UniProtKB/Swiss-Prot
    Q9NPI5
    Related
    ENSP00000480091.1, ENST00000616156.4
    Conserved Domains (1) summary
    cd02024
    Location:4169
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  2. NM_170678.2NP_733778.1  nicotinamide riboside kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_733778.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK001663, BM669267
    Consensus CDS
    CCDS12115.1
    UniProtKB/Swiss-Prot
    Q9NPI5
    Related
    ENSP00000168977.1, ENST00000168977.6
    Conserved Domains (1) summary
    cd02024
    Location:4164
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

RNA

  1. NR_110316.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK001663, BM669267, BM717225
    Related
    ENST00000599576.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    3933103..3942416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722725.3XP_006722788.1  nicotinamide riboside kinase 2 isoform X1

    Conserved Domains (1) summary
    cd02024
    Location:4145
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  2. XM_006722726.3XP_006722789.1  nicotinamide riboside kinase 2 isoform X3

    Conserved Domains (1) summary
    cd02024
    Location:4137
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  3. XM_024451452.1XP_024307220.1  nicotinamide riboside kinase 2 isoform X2

    Conserved Domains (1) summary
    cd02024
    Location:4140
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  4. XM_017026597.1XP_016882086.1  nicotinamide riboside kinase 2 isoform X4

    Conserved Domains (1) summary
    cd02024
    Location:4132
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014446.1: Suppressed sequence

    Description
    NM_014446.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center