Format

Send to:

Choose Destination

NOX1 NADPH oxidase 1 [ Homo sapiens (human) ]

Gene ID: 27035, updated on 15-Apr-2019

Summary

Official Symbol
NOX1provided by HGNC
Official Full Name
NADPH oxidase 1provided by HGNC
Primary source
HGNC:HGNC:7889
See related
Ensembl:ENSG00000007952 MIM:300225
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOX1; NOH1; NOH-1; GP91-2
Summary
This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Expression
Restricted expression toward colon (RPKM 30.7) See more
Orthologs

Genomic context

See NOX1 in Genome Data Viewer
Location:
Xq22.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (100843324..100874345, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100098313..100129334, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RAD21 homolog (S. pombe) pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene 89 Neighboring gene cleavage stimulation factor subunit 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 26 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 27 Neighboring gene XK related X-linked Neighboring gene NSA2 ribosome biogenesis homolog (S. cerevisiae) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CXCR4 induces NADPH oxidase-mediated production of superoxide radicals in neurons, which is involved in the activation of neutral sphingomyelinase PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 inhibits the cellular immune response and enhances oxidative stress mediated by NADPH oxidase PubMed
Envelope transmembrane glycoprotein gp41 env The 3S motif of HIV-1 gp41 stimulates ROS production by NADPH oxidase PubMed
Nef nef NADPH oxidase is required for HIV-1 Nef-induced ROS production and endothelial apoptosis in human coronary arterial endothelial cells PubMed
nef HIV-1 Nef-induced blockade of superoxide release is caused by the inhibition of NADPH oxidase activities in human macrophages; this inhibition is regulated by Nef-mediated increased synthesis and release of IL-10 PubMed
nef Nef induces the phosphorylation and then the translocation of the cytosolic subunit of NADPH oxidase complex p47(phox) to the plasma membrane PubMed
nef Both Nef membrane localization and intact SH3-binding domain are involved in NADPH oxidase activation and superoxide anion release PubMed
Tat tat PDGF-BB inhibits NADPH oxidase-mediated reactive oxygen species production induced by HIV-1 Tat and morphine treatment in neuroblastoma cells PubMed
tat The NADPH oxidase inhibitors DPI and apocynin abrogate HIV-1 Tat-stimulated ERK1/2 activation in human microglia-like cells PubMed
tat HIV-1 Tat increases CXCL10 expression in IFN-gamma and TNF-alpha stimulated human astrocytes via NADPH oxidase PubMed
tat Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • RAC1 signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    RAC1 signaling pathway, organism-specific biosystem
    RAC1 signaling pathway
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate NADPH Oxidases, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate NADPH Oxidases, organism-specific biosystemNADPH oxidases (NOX) are membrane-associated enzymatic complexes that use NADPH as an electon donor to reduce oxygen and produce superoxide (O2-) that serves as a secondary messenger (Brown and Grien...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADP binding IC
Inferred by Curator
more info
PubMed 
Rac GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
superoxide-generating NADPH oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide-generating NADPH oxidase activity IC
Inferred by Curator
more info
PubMed 
superoxide-generating NADPH oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
superoxide-generating NADPH oxidase activity TAS
Traceable Author Statement
more info
PubMed 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NADP metabolic process IC
Inferred by Curator
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hyperoxia IEA
Inferred from Electronic Annotation
more info
 
cellular stress response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
intracellular pH elevation IDA
Inferred from Direct Assay
more info
PubMed 
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxygen metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of integrin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of vascular endothelial growth factor production IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure by renin-angiotensin IEA
Inferred from Electronic Annotation
more info
 
respiratory burst TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADPH oxidase complex IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
invadopodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
NADPH oxidase 1
Names
NADH/NADPH mitogenic oxidase subunit P65-MOX
NADPH oxidase homolog-1
mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating)
mitogenic oxidase 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012567.1 RefSeqGene

    Range
    5001..36022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001271815.1NP_001258744.1  NADPH oxidase 1 isoform 3

    See identical proteins and their annotated locations for NP_001258744.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame 5' coding exon, compared to variant 1 (NOH-1L). The resulting isoform (3) has the same N- and C-termini but is shorter, compared to isoform 1.
    Source sequence(s)
    AF127763, AF166327, AI285296, AK292201, BX956931, DQ424904, Z83819
    Consensus CDS
    CCDS65298.1
    UniProtKB/Swiss-Prot
    Q9Y5S8
    UniProtKB/TrEMBL
    A6NGA6, Q1ZYL4
    Related
    ENSP00000362051.4, ENST00000372960.8
    Conserved Domains (2) summary
    cd06186
    Location:260527
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:48176
    Ferric_reduct; Ferric reductase like transmembrane component
  2. NM_007052.5NP_008983.2  NADPH oxidase 1 isoform 1

    See identical proteins and their annotated locations for NP_008983.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, alternately referred to as NOH-1L per PMID: 10615049) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF127763, AF166327, BX956931, Z83819
    Consensus CDS
    CCDS14474.1
    UniProtKB/Swiss-Prot
    Q9Y5S8
    Related
    ENSP00000362057.3, ENST00000372966.8
    Conserved Domains (2) summary
    cd06186
    Location:297564
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:66213
    Ferric_reduct; Ferric reductase like transmembrane component
  3. NM_013955.2NP_039249.1  NADPH oxidase 1 isoform 2

    See identical proteins and their annotated locations for NP_039249.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, alternately referred to as NOH-1Lv per PMID: 10615049) lacks an alternate in-frame coding exon, compared to variant 1 (NOH-1L). The resulting isoform (2) has the same N- and C-termini but is shorter, compared to isoform 1.
    Source sequence(s)
    AF127763, AF166328, BX956931, Z83819
    Consensus CDS
    CCDS14475.1
    UniProtKB/Swiss-Prot
    Q9Y5S8
    Related
    ENSP00000217885.5, ENST00000217885.5
    Conserved Domains (2) summary
    cd06186
    Location:297515
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:66213
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    100843324..100874345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029407.2XP_016884896.1  NADPH oxidase 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_013954.1: Suppressed sequence

    Description
    NM_013954.1: This RefSeq was permanently suppressed because the submitters of the transcript data determined that this was not a biologically valid sequence.
Support Center