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GAGE1 G antigen 1 [ Homo sapiens (human) ]

Gene ID: 2543, updated on 13-Apr-2019

Summary

Official Symbol
GAGE1provided by HGNC
Official Full Name
G antigen 1provided by HGNC
Primary source
HGNC:HGNC:4098
See related
Ensembl:ENSG00000205777 MIM:300594
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT4.1; CT4.4; GAGE4; GAGE-1; GAGE-4
Summary
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. Nothing is presently known about the function of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Expression
Restricted expression toward testis (RPKM 23.5) See more

Genomic context

See GAGE1 in Genome Data Viewer
Location:
Xp11.23
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (49598992..49608536)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (49363616..49373139)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene G antigen 12H Neighboring gene G antigen 2A Neighboring gene voltage dependent anion channel 1 pseudogene 2 Neighboring gene spalt like transcription factor 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC33825

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
G antigen 1
Names
Cancer/testis antigen 4.4
G antigen 4
MZ2-F antigen
cancer/testis antigen 4.1
cancer/testis antigen family 4, member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040663.2NP_001035753.1  G antigen 1

    See identical proteins and their annotated locations for NP_001035753.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the functional protein.
    Source sequence(s)
    AC231643, BC036094, BC069470
    Consensus CDS
    CCDS43950.1
    UniProtKB/Swiss-Prot
    Q13068
    UniProtKB/TrEMBL
    A0A158RFV5
    Related
    ENSP00000371119.5, ENST00000381700.10
    Conserved Domains (1) summary
    pfam05831
    Location:1114
    GAGE; GAGE protein

RNA

  1. NR_102272.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon compared to variant 2. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC036094, DC401704
    Related
    ENST00000381709.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    49598992..49608536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543896.2XP_011542198.1  G antigen 1 isoform X1

    Conserved Domains (1) summary
    pfam05831
    Location:1111
    GAGE; GAGE protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001468.4: Suppressed sequence

    Description
    NM_001468.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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