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IL17RA interleukin 17 receptor A [ Homo sapiens (human) ]

Gene ID: 23765, updated on 21-Apr-2019

Summary

Official Symbol
IL17RAprovided by HGNC
Official Full Name
interleukin 17 receptor Aprovided by HGNC
Primary source
HGNC:HGNC:5985
See related
Ensembl:ENSG00000177663 MIM:605461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R
Summary
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in bone marrow (RPKM 11.6), appendix (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See IL17RA in Genome Data Viewer
Location:
22q11.1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (17084959..17115694)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (17565849..17596584)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 9 pseudogene Neighboring gene cat eye syndrome chromosome region, candidate 7 Neighboring gene ribosomal protein L31 pseudogene 62 Neighboring gene transmembrane protein 121B Neighboring gene long intergenic non-protein coding RNA 1664

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Immunodeficiency 51
MedGen: C4310803 OMIM: 613953 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
    IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • IL-17 signaling pathway, conserved biosystem (from KEGG)
    IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • IL17 signaling pathway, organism-specific biosystem (from WikiPathways)
    IL17 signaling pathway, organism-specific biosystemInterleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-17 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-17 signaling, organism-specific biosystemInterleukin-17 (IL17) is a family of cytokines (Kawaguchi et al. 2004, Gu et al. 2013). IL17A, the founding member of the family, member of this family, is able to induce the production of other cyt...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CECR7

Homology

Clone Names

  • FLJ32274, FLJ36453, MGC10262

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-17 receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
defense response to fungus IEA
Inferred from Electronic Annotation
more info
 
fibroblast activation IDA
Inferred from Direct Assay
more info
PubMed 
granulocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
interleukin-17-mediated signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-13 secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-23 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-5 secretion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-17 receptor A
Names
IL-17 receptor A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028257.1 RefSeqGene

    Range
    4999..35734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_355

mRNA and Protein(s)

  1. NM_001289905.1NP_001276834.1  interleukin-17 receptor A isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes a soluble isoform, isoform 2 which is shorter and lacks a transmembrane region, when compared to isoform 1.
    Source sequence(s)
    AC006946, BX368715, BX410574
    Consensus CDS
    CCDS77645.1
    UniProtKB/Swiss-Prot
    Q96F46
    Related
    ENSP00000479970.1, ENST00000612619.1
    Conserved Domains (3) summary
    pfam08357
    Location:344502
    SEFIR; SEFIR domain
    pfam16556
    Location:48198
    IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
    pfam16578
    Location:199303
    IL17R_fnIII_D2; Interleukin 17 receptor D
  2. NM_014339.6NP_055154.3  interleukin-17 receptor A isoform 1 precursor

    See identical proteins and their annotated locations for NP_055154.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC006946, BU585070, BX334547, CB044543, U58917
    Consensus CDS
    CCDS13739.1
    UniProtKB/Swiss-Prot
    Q96F46
    Related
    ENSP00000320936.6, ENST00000319363.10
    Conserved Domains (3) summary
    pfam08357
    Location:378536
    SEFIR; SEFIR domain
    pfam16556
    Location:48198
    IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
    pfam16578
    Location:199303
    IL17R_fnIII_D2; Interleukin 17 receptor D

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    17084959..17115694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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