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FPR2 formyl peptide receptor 2 [ Homo sapiens (human) ]

Gene ID: 2358, updated on 15-Apr-2019

Summary

Official Symbol
FPR2provided by HGNC
Official Full Name
formyl peptide receptor 2provided by HGNC
Primary source
HGNC:HGNC:3827
See related
Ensembl:ENSG00000171049 MIM:136538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALXR; HM63; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; LXA4R; FMLP-R-II
Expression
Biased expression in appendix (RPKM 23.5), spleen (RPKM 4.6) and 5 other tissues See more
Orthologs

Genomic context

See FPR2 in Genome Data Viewer
Location:
19q13.41
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (51752026..51770526)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52264453..52273779)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sperm acrosome associated 6 Neighboring gene hyaluronan synthase 1 Neighboring gene formyl peptide receptor 1 Neighboring gene uncharacterized LOC105372448 Neighboring gene uncharacterized LOC105369197 Neighboring gene formyl peptide receptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env FPRL1 is an alternative coreceptor usage by R5-tropic HIV-1 type C gp120/gp41, although its usage frequency is less than that of CCR5 coreceptor. The gp120 V3 crown is an important determinant for the efficient FPRL1 usage by the type-C virus PubMed
env A synthetic peptide domain of the V3 region of HIV-1 gp120 activates the FPRL1 receptor in monocytes and neutrophils and causes reduced response to several chemokines that use multiple cell receptors, including SDF-1alpha and RANTES PubMed
env A synthetic peptide corresponding to amino acid residues 414-434 of HIV-1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R PubMed
Envelope transmembrane glycoprotein gp41 env FPRL1 is an alternative coreceptor usage by R5-tropic HIV-1 type C gp120/gp41, although its usage frequency is less than that of CCR5 coreceptor PubMed
env Matriptase, a serine protease, efficiently cleaves the HR1 portion of HIV-1 gp41 into a 22-residue chemotactic peptide MAT-1, leading to chemotaxis by using FPR2 in primary neutrophils PubMed
env HIV-1 gp41 activates innate host immune cells through FPRL1, and the activation of FPRL1 by gp41 further induces the phosphorylation of the chemokine receptor CCR5 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystem (from REACTOME)
    Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystemThe formyl peptide receptor (FPR) was defined pharmacologically in 1976 as a high affinity binding site on the surface of neutrophils for the peptide N-formyl-methionine-leucine-phenylalanine (fMLF)....
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
    Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
  • Staphylococcus aureus infection, conserved biosystem (from KEGG)
    Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
N-formyl peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amyloid-beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cargo receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
scavenger receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
astrocyte activation ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-mediated signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cellular response to amyloid-beta IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to amyloid-beta ISS
Inferred from Sequence or Structural Similarity
more info
 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microglial cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of 1-phosphatidylinositol-3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of monocyte chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of superoxide anion generation ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
N-formyl peptide receptor 2
Names
FMLP-R-I
FMLP-related receptor I
LXA4 receptor
RFP
formyl peptide receptor-like 1
lipoxin A4 receptor (formyl peptide receptor related)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005738.2NP_001005738.1  N-formyl peptide receptor 2

    See identical proteins and their annotated locations for NP_001005738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC018755, BC071722, BM922150, D10922
    Consensus CDS
    CCDS12840.1
    UniProtKB/Swiss-Prot
    P25090
    UniProtKB/TrEMBL
    A0A024R4P3
    Related
    ENSP00000340191.4, ENST00000340023.7
    Conserved Domains (1) summary
    cd15117
    Location:27313
    7tmA_FPR-like; N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001462.3NP_001453.1  N-formyl peptide receptor 2

    See identical proteins and their annotated locations for NP_001453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    D10922, X63819
    Consensus CDS
    CCDS12840.1
    UniProtKB/Swiss-Prot
    P25090
    UniProtKB/TrEMBL
    A0A024R4P3
    Related
    ENSP00000468897.1, ENST00000598776.1
    Conserved Domains (1) summary
    cd15117
    Location:27313
    7tmA_FPR-like; N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    51752026..51770526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723120.3XP_006723183.1  N-formyl peptide receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_006723183.1

    UniProtKB/Swiss-Prot
    P25090
    UniProtKB/TrEMBL
    A0A024R4P3
    Conserved Domains (1) summary
    cd15117
    Location:27313
    7tmA_FPR-like; N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
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