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FOLR2 folate receptor beta [ Homo sapiens (human) ]

Gene ID: 2350, updated on 21-Apr-2019

Summary

Official Symbol
FOLR2provided by HGNC
Official Full Name
folate receptor betaprovided by HGNC
Primary source
HGNC:HGNC:3793
See related
Ensembl:ENSG00000165457 MIM:136425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBP; FR-P3; FR-BETA; BETA-HFR; FBP/PL-1
Summary
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 67.9), gall bladder (RPKM 33.0) and 20 other tissues See more
Orthologs

Genomic context

See FOLR2 in Genome Data Viewer
Location:
11q13.4
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (72216773..72221950)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71927819..71932994)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene folate receptor 3 pseudogene 1 Neighboring gene folate receptor 1 Neighboring gene skeletal muscle cis-regulatory module in INPPL1 intron Neighboring gene inositol polyphosphate phosphatase like 1 Neighboring gene paired like homeobox 2A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of folate receptor 2 (FOLR2) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Antifolate resistance, organism-specific biosystem (from KEGG)
    Antifolate resistance, organism-specific biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Antifolate resistance, conserved biosystem (from KEGG)
    Antifolate resistance, conserved biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Folate Metabolism, organism-specific biosystem (from WikiPathways)
    Folate Metabolism, organism-specific biosystem
    Folate Metabolism
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of folate and pterines, organism-specific biosystem (from REACTOME)
    Metabolism of folate and pterines, organism-specific biosystemFolates are essential cofactors that provide one-carbon moieties in various states of reduction for biosynthetic reactions. Processes annotated here include transport reactions by which folates are t...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
  • Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of water-soluble vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only ...
  • Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystem (from REACTOME)
    Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystemGlycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactio...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
drug binding IPI
Inferred from Physical Interaction
more info
PubMed 
folic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
folic acid receptor activity IC
Inferred by Curator
more info
PubMed 
folic acid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
methotrexate binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to folic acid IEA
Inferred from Electronic Annotation
more info
 
folate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
folic acid metabolic process TAS
Traceable Author Statement
more info
 
folic acid transport IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
NOT monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor-mediated endocytosis IC
Inferred by Curator
more info
PubMed 
regulation of thymidylate synthase biosynthetic process IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
anchored component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
folate receptor beta
Names
folate receptor 2 (fetal)
folate receptor, fetal/placental
folate-binding protein, fetal/placental
placental folate-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000803.5NP_000794.3  folate receptor beta precursor

    See identical proteins and their annotated locations for NP_000794.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein.
    Source sequence(s)
    AK222643, CD014063
    Consensus CDS
    CCDS8212.1
    UniProtKB/Swiss-Prot
    P14207
    Related
    ENSP00000298223.6, ENST00000298223.11
    Conserved Domains (1) summary
    pfam03024
    Location:30205
    Folate_rec; Folate receptor family
  2. NM_001113534.1NP_001107006.1  folate receptor beta precursor

    See identical proteins and their annotated locations for NP_001107006.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    BM849995, CD014063, CD692073
    Consensus CDS
    CCDS8212.1
    UniProtKB/Swiss-Prot
    P14207
    Conserved Domains (1) summary
    pfam03024
    Location:30205
    Folate_rec; Folate receptor family
  3. NM_001113535.1NP_001107007.1  folate receptor beta precursor

    See identical proteins and their annotated locations for NP_001107007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    BM691283, BM849995, CD014063
    Consensus CDS
    CCDS8212.1
    UniProtKB/Swiss-Prot
    P14207
    Conserved Domains (1) summary
    pfam03024
    Location:30205
    Folate_rec; Folate receptor family
  4. NM_001113536.1NP_001107008.1  folate receptor beta precursor

    See identical proteins and their annotated locations for NP_001107008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    BM849995, BY797003, CD014063
    Consensus CDS
    CCDS8212.1
    UniProtKB/Swiss-Prot
    P14207
    Conserved Domains (1) summary
    pfam03024
    Location:30205
    Folate_rec; Folate receptor family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    72216773..72221950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448412.1XP_024304180.1  folate receptor beta isoform X1

    Related
    ENSP00000405638.2, ENST00000449475.6
    Conserved Domains (1) summary
    pfam03024
    Location:47222
    Folate_rec; Folate receptor family
  2. XM_005273856.4XP_005273913.1  folate receptor beta isoform X2

    Conserved Domains (1) summary
    pfam03024
    Location:39214
    Folate_rec; Folate receptor family
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