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FCGR2B Fc fragment of IgG receptor IIb [ Homo sapiens (human) ]

Gene ID: 2213, updated on 7-Apr-2019

Summary

Official Symbol
FCGR2Bprovided by HGNC
Official Full Name
Fc fragment of IgG receptor IIbprovided by HGNC
Primary source
HGNC:HGNC:3618
See related
Ensembl:ENSG00000072694 MIM:604590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcRII-c
Summary
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Expression
Biased expression in placenta (RPKM 92.9), appendix (RPKM 9.6) and 6 other tissues See more
Orthologs

Genomic context

See FCGR2B in Genome Data Viewer
Location:
1q23.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (161647243..161678654)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161632905..161648444)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S23 pseudogene 9 Neighboring gene Fc fragment of IgG receptor IIIb Neighboring gene ribosomal protein L31 pseudogene 11 Neighboring gene Fc receptor like A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Susceptibility to malaria
MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
Compare labs
Systemic lupus erythematosus
MedGen: C0024141 OMIM: 152700 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
Nef nef HIV-1 Nef downregulates Fc-gamma Receptor II in human monocytes/macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
  • B cell receptor signaling pathway, conserved biosystem (from KEGG)
    B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
  • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    BCR signaling pathway, organism-specific biosystem
    BCR signaling pathway
  • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
    Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
    Fc-epsilon receptor I signaling in mast cells
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
    Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
  • Staphylococcus aureus infection, conserved biosystem (from KEGG)
    Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgG binding IDA
Inferred from Direct Assay
more info
PubMed 
amyloid-beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
amyloid-beta binding TAS
Traceable Author Statement
more info
PubMed 
low-affinity IgG receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to amyloid-beta ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to molecule of bacterial origin ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cerebellum development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
defense response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
follicular B cell differentiation TAS
Traceable Author Statement
more info
PubMed 
follicular dendritic cell activation TAS
Traceable Author Statement
more info
PubMed 
immune complex clearance by monocytes and macrophages TAS
Traceable Author Statement
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
immunoglobulin mediated immune response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
NOT mast cell activation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mature B cell differentiation involved in immune response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of B cell activation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of acute inflammatory response to antigenic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of antibody-dependent cellular cytotoxicity TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cytokine secretion TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cytotoxic T cell degranulation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of dendritic cell antigen processing and presentation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of dendritic cell differentiation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of humoral immune response mediated by circulating immunoglobulin ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of immune response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of immunoglobulin production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of interleukin-10 production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of macrophage activation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of neutrophil activation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of phagocytosis TAS
Traceable Author Statement
more info
PubMed 
negative regulation of type I hypersensitivity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of humoral immune response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of B cell antigen processing and presentation TAS
Traceable Author Statement
more info
PubMed 
regulation of adaptive immune response TAS
Traceable Author Statement
more info
PubMed 
regulation of dendritic spine maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of immune complex clearance by monocytes and macrophages TAS
Traceable Author Statement
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
regulation of innate immune response TAS
Traceable Author Statement
more info
PubMed 
regulation of signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell body ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
low affinity immunoglobulin gamma Fc region receptor II-b
Names
CDw32
Fc fragment of IgG, low affinity II, receptor for (CD32)
Fc fragment of IgG, low affinity IIb, receptor (CD32)
Fc fragment of IgG, low affinity IIb, receptor for (CD32)
Fc gamma RIIb
Fc gamma receptor IIb
Fc-gamma RII-c
Fc-gamma-RIIc
IgG Fc receptor II-c
Low affinity immunoglobulin gamma Fc region receptor II-c
fc-gamma RII-b
fc-gamma-RIIb
fcRII-b
igG Fc receptor II-b

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023318.1 RefSeqGene

    Range
    5001..20540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002273.2NP_001002273.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 2 precursor

    See identical proteins and their annotated locations for NP_001002273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK308150, AW452813, DC381078, U87571
    UniProtKB/Swiss-Prot
    P31994
    Conserved Domains (2) summary
    cd05752
    Location:49127
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:131213
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  2. NM_001002274.2NP_001002274.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 3 precursor

    See identical proteins and their annotated locations for NP_001002274.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK308150, AW452813, DC381078, U87564
    Consensus CDS
    CCDS30925.1
    UniProtKB/Swiss-Prot
    P31994
    Related
    ENSP00000236937.9, ENST00000236937.13
    Conserved Domains (2) summary
    cd05752
    Location:50128
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:132214
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  3. NM_001002275.2NP_001002275.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 4 precursor

    See identical proteins and their annotated locations for NP_001002275.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AK308150, AW452813, DC381078, U87570
    UniProtKB/Swiss-Prot
    P31994
    Conserved Domains (2) summary
    cd05752
    Location:49127
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:131213
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  4. NM_001190828.1NP_001177757.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 5

    See identical proteins and their annotated locations for NP_001177757.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK308150, AW452813, DC381078, M31933, U87560
    Consensus CDS
    CCDS53414.1
    UniProtKB/Swiss-Prot
    P31994
    Related
    ENSP00000356938.4, ENST00000367961.8
    Conserved Domains (3) summary
    cd05752
    Location:43121
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:125207
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:131207
    IG_like; Immunoglobulin like
  5. NM_004001.4NP_003992.3  low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor

    See identical proteins and their annotated locations for NP_003992.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK308150, AW452813, DC381078, U87560
    Consensus CDS
    CCDS30924.1
    UniProtKB/Swiss-Prot
    P31994
    Related
    ENSP00000351497.5, ENST00000358671.9
    Conserved Domains (2) summary
    cd05752
    Location:50128
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:132214
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    161647243..161678654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454044.1XP_024309812.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform X3

    Conserved Domains (2) summary
    cd05752
    Location:49127
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:131213
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  2. XM_024454045.1XP_024309813.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform X4

    Conserved Domains (2) summary
    cd05752
    Location:49127
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:131213
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  3. XM_017000670.2XP_016856159.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform X2

  4. XM_024454043.1XP_024309811.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform X1

    Conserved Domains (2) summary
    cd05752
    Location:50128
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:132214
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  5. XM_024454047.1XP_024309815.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform X5

    Conserved Domains (2) summary
    cd05752
    Location:50128
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:132214
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

RNA

  1. XR_002959731.1 RNA Sequence

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