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FABP3 fatty acid binding protein 3 [ Homo sapiens (human) ]

Gene ID: 2170, updated on 23-Apr-2019

Summary

Official Symbol
FABP3provided by HGNC
Official Full Name
fatty acid binding protein 3provided by HGNC
Primary source
HGNC:HGNC:3557
See related
Ensembl:ENSG00000121769 MIM:134651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDGI; FABP11; H-FABP; M-FABP; O-FABP
Summary
The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Biased expression in heart (RPKM 311.6), brain (RPKM 22.8) and 1 other tissue See more
Orthologs

Genomic context

See FABP3 in Genome Data Viewer
Location:
1p35.2
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (31359595..31373618, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (31838100..31845923, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene sodium/potassium transporting ATPase interacting 1 Neighboring gene small nuclear ribonucleoprotein U5 subunit 40 Neighboring gene zinc finger CCHC-type containing 17 Neighboring gene uncharacterized LOC105378623 Neighboring gene uncharacterized LOC107985470

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of fatty acid binding protein 3 (FABP3) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystem (from REACTOME)
    Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystemTriacylglycerol is a major energy store in the body and its hydrolysis to yield fatty acids and glycerol is a tightly regulated part of energy metabolism. A central part in this regulation is played ...
  • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
    Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
icosatetraenoic acid binding IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid binding IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid transporter activity IEA
Inferred from Electronic Annotation
more info
 
oleic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
intracellular lipid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
long-chain fatty acid transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
phospholipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of long-chain fatty acid import into cell ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of phospholipid biosynthetic process IC
Inferred by Curator
more info
PubMed 
regulation of fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
triglyceride catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fatty acid-binding protein, heart
Names
epididymis secretory sperm binding protein
fatty acid binding protein 11
fatty acid binding protein 3, muscle and heart
heart-type fatty acid-binding protein
mammary-derived growth inhibitor
muscle fatty acid-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047049.1 RefSeqGene

    Range
    4996..13031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320996.1NP_001307925.1  fatty acid-binding protein, heart isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL451070, BF576953, BI752278, BP194697, CN283506
    Conserved Domains (1) summary
    pfam00061
    Location:6143
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  2. NM_004102.4NP_004093.1  fatty acid-binding protein, heart isoform 2

    See identical proteins and their annotated locations for NP_004093.1

    Status: REVIEWED

    Source sequence(s)
    AL451070, BC007021, BP194697
    Consensus CDS
    CCDS342.1
    UniProtKB/Swiss-Prot
    P05413
    Related
    ENSP00000362817.2, ENST00000373713.6
    Conserved Domains (1) summary
    pfam00061
    Location:6119
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    31359595..31373618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541007.3XP_011539309.1  fatty acid-binding protein, heart isoform X1

    See identical proteins and their annotated locations for XP_011539309.1

    Conserved Domains (1) summary
    pfam00061
    Location:6116
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
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