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EPHA5 EPH receptor A5 [ Homo sapiens (human) ]

Gene ID: 2044, updated on 13-Feb-2019

Summary

Official Symbol
EPHA5provided by HGNC
Official Full Name
EPH receptor A5provided by HGNC
Primary source
HGNC:HGNC:3389
See related
Ensembl:ENSG00000145242 MIM:600004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EK7; CEK7; EHK1; HEK7; EHK-1; TYRO4
Summary
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]
Expression
Biased expression in brain (RPKM 4.9), ovary (RPKM 1.0) and 6 other tissues See more
Orthologs

Genomic context

See EPHA5 in Genome Data Viewer
Location:
4q13.1-q13.2
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (65319563..65670495, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (66185281..66536529, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 pseudogene Neighboring gene uncharacterized LOC105377256 Neighboring gene ribosomal protein L6 pseudogene 10 Neighboring gene EPHA5 antisense RNA 1 Neighboring gene uncharacterized LOC105377258 Neighboring gene RNA, U2 small nuclear 40, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
NHGRI GWA Catalog

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
  • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
    EPH-ephrin mediated repulsion of cells, organism-specific biosystemDespite high-affinity multimeric interaction between EPHs and ephrins (EFNs), the cellular response to EPH-EFN engagement is usually repulsion between the two cells and signal termination. These repu...
  • EPHA forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHA forward signaling, organism-specific biosystem
    EPHA forward signaling
  • EPHA-mediated growth cone collapse, organism-specific biosystem (from REACTOME)
    EPHA-mediated growth cone collapse, organism-specific biosystemEPH/Ephrin signaling is coupled to Rho family GTPases such as Rac, Rho and Cdc42 that connect bidirectional receptor-ligand interactions to changes in the actin cytoskeleton (Noren & Pasquale 2004, G...
  • Ephrin A reverse signaling, organism-specific biosystem (from Pathway Interaction Database)
    Ephrin A reverse signaling, organism-specific biosystem
    Ephrin A reverse signaling
  • EphrinA-EPHA pathway, organism-specific biosystem (from Pathway Interaction Database)
    EphrinA-EPHA pathway, organism-specific biosystem
    EphrinA-EPHA pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GPI-linked ephrin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ephrin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane-ephrin receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
ephrin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
hippocampus development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippocampus development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron development IEP
Inferred from Expression Pattern
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of CREB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ephrin type-A receptor 5
Names
EPH homology kinase 1
EPH-like kinase 7
brain-specific kinase
epididymis secretory sperm binding protein
receptor protein-tyrosine kinase HEK7
tyrosine-protein kinase receptor EHK-1
NP_001268694.1
NP_001268695.1
NP_001268696.1
NP_001305690.1
NP_004430.4
NP_872272.2
XP_005265710.1
XP_011530037.1
XP_016863367.1
XP_016863368.1
XP_016863369.1
XP_016863370.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281765.2NP_001268694.1  ephrin type-A receptor 5 isoform c

    See identical proteins and their annotated locations for NP_001268694.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest protein (isoform c).
    Source sequence(s)
    AC018683, AC104137, BC136257, BX537946
    Consensus CDS
    CCDS75133.1
    UniProtKB/Swiss-Prot
    P54756
    UniProtKB/TrEMBL
    B7ZKJ3
    Related
    ENSP00000480763.1, ENST00000622150.4
    Conserved Domains (7) summary
    cd09546
    Location:9661031
    SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
    smart00454
    Location:9701028
    SAM; Sterile alpha motif
    cd10483
    Location:60232
    EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
    cd00063
    Location:469559
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:671937
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:676933
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:579671
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  2. NM_001281766.2NP_001268695.1  ephrin type-A receptor 5 isoform d

    See identical proteins and their annotated locations for NP_001268695.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the coding region compared to variant 3. The resulting protein (isoform d) is shorter but has the same N- and C-termini compared to isoform c.
    Source sequence(s)
    AC018683, AC104137, BC143427, BX537946
    Consensus CDS
    CCDS75131.1
    UniProtKB/Swiss-Prot
    P54756
    UniProtKB/TrEMBL
    B7ZKW7
    Related
    ENSP00000478537.1, ENST00000613740.4
    Conserved Domains (7) summary
    cd09546
    Location:9441009
    SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
    smart00454
    Location:9481006
    SAM; Sterile alpha motif
    cd10483
    Location:60232
    EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
    cd00063
    Location:469559
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:649915
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:654911
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:579649
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  3. NM_001281767.2NP_001268696.1  ephrin type-A receptor 5 isoform e

    See identical proteins and their annotated locations for NP_001268696.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) includes a 3' terminal exon that extends past a splice site used in variant c, resulting in a different 3' coding region and 3' UTR. The resulting protein (isoform e) is shorter and has a distinct C-terminus compared to isoform c.
    Source sequence(s)
    AB209375, AC018683, AC104137, BM664168, H11658
    Consensus CDS
    CCDS75132.1
    UniProtKB/TrEMBL
    F8VP57, Q59FT4
    Related
    ENSP00000427638.1, ENST00000511294.1
    Conserved Domains (6) summary
    cd10483
    Location:60232
    EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
    cd00063
    Location:469559
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:671937
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:676933
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:579671
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl15755
    Location:9661004
    SAM_superfamily; SAM (Sterile alpha motif )
  4. NM_001318761.1NP_001305690.1  ephrin type-A receptor 5 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting protein (isoform f) has a shorter N-terminus compared to isoform c.
    Source sequence(s)
    AC018683, BC136258, BX537946
    UniProtKB/Swiss-Prot
    P54756
    UniProtKB/TrEMBL
    B7ZKJ3
    Conserved Domains (7) summary
    cd09546
    Location:897962
    SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
    smart00454
    Location:901959
    SAM; Sterile alpha motif
    cd00063
    Location:400490
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:602868
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:607864
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:510602
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1163
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  5. NM_004439.7NP_004430.4  ephrin type-A receptor 5 isoform a

    See identical proteins and their annotated locations for NP_004430.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) used an alternate splice site in the coding region compared to variant 3. The resulting protein (isoform a) is shorter but has the same N- and C-termini compared to isoform c.
    Source sequence(s)
    AB209375, AC018683, AC104137, BC136257, BX537946, X95425
    Consensus CDS
    CCDS3513.1
    UniProtKB/Swiss-Prot
    P54756
    UniProtKB/TrEMBL
    B7ZKJ3, Q59FT4
    Related
    ENSP00000273854.3, ENST00000273854.7
    Conserved Domains (6) summary
    cd09546
    Location:9651030
    SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
    cd10483
    Location:60232
    EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
    cd00063
    Location:469559
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:670936
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:359447
    fn3; Fibronectin type III domain
    pfam14575
    Location:578670
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  6. NM_182472.4NP_872272.2  ephrin type-A receptor 5 isoform b

    See identical proteins and their annotated locations for NP_872272.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks an alternate exon in the coding region compared to variant 3. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform c.
    Source sequence(s)
    AB209375, AC018683, AC104137, BC136257, BX537946, L36644, X95425
    Consensus CDS
    CCDS3514.1
    UniProtKB/Swiss-Prot
    P54756
    UniProtKB/TrEMBL
    B7ZKJ3, Q59FT4
    Related
    ENSP00000346899.4, ENST00000354839.8
    Conserved Domains (7) summary
    cd09546
    Location:9431008
    SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
    smart00454
    Location:9471005
    SAM; Sterile alpha motif
    cd10483
    Location:60232
    EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
    cd00063
    Location:469559
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:648914
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:653910
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:578648
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    65319563..65670495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265653.4XP_005265710.1  ephrin type-A receptor 5 isoform X3

    UniProtKB/TrEMBL
    F8W9W0
    Related
    ENSP00000389208.2, ENST00000432638.6
    Conserved Domains (7) summary
    cd09546
    Location:802867
    SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
    smart00454
    Location:806864
    SAM; Sterile alpha motif
    cd10483
    Location:60232
    EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
    cd00063
    Location:305395
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:507773
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:512769
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:415507
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  2. XM_011531735.3XP_011530037.1  ephrin type-A receptor 5 isoform X1

    Conserved Domains (7) summary
    cd09546
    Location:854919
    SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
    smart00454
    Location:858916
    SAM; Sterile alpha motif
    cd10483
    Location:60232
    EphR_LBD_A5; Ligand Binding Domain of Ephrin type-A Receptor 5
    cd00063
    Location:357447
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:559825
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:564821
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:467559
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  3. XM_017007880.2XP_016863369.1  ephrin type-A receptor 5 isoform X5

  4. XM_017007878.2XP_016863367.1  ephrin type-A receptor 5 isoform X2

  5. XM_017007881.2XP_016863370.1  ephrin type-A receptor 5 isoform X6

  6. XM_017007879.2XP_016863368.1  ephrin type-A receptor 5 isoform X4

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