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ELF2 E74 like ETS transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 1998, updated on 3-Mar-2019

Summary

Official Symbol
ELF2provided by HGNC
Official Full Name
E74 like ETS transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:3317
See related
Ensembl:ENSG00000109381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EU32; NERF; NERF-2; NERF-1A; NERF-1B; NERF-1a,b
Expression
Ubiquitous expression in testis (RPKM 17.8), bone marrow (RPKM 13.2) and 25 other tissues See more
Orthologs

Genomic context

See ELF2 in Genome Data Viewer
Location:
4q31.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (139057258..139177218, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (139978871..140098372, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene nocturnin Neighboring gene RNA, U6 small nuclear 531, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 382, pseudogene Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 3 Neighboring gene uncharacterized LOC105379412 Neighboring gene RNA, 7SL, cytoplasmic 311, pseudogene Neighboring gene RNA, U6 small nuclear 506, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of B cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ETS-related transcription factor Elf-2
Names
E74-like factor 2 (ets domain transcription factor)
ets family transcription factor ELF2C
new Ets-related factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276457.1NP_001263386.1  ETS-related transcription factor Elf-2 isoform 3

    See identical proteins and their annotated locations for NP_001263386.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate exon in place of the first three exons, uses an alternate in-frame splice junction at the 5' end of an internal exon, and lacks an alternate in-frame exon compared to variant 1. Translation starts in the alternate exon, so the resulting isoform (3) has a shorter and distinct N-terminus, contains an alternate internal segment, and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AF256222, BC034951, BC065025, U43188
    Consensus CDS
    CCDS64063.1
    UniProtKB/Swiss-Prot
    Q15723
    Related
    ENSP00000368867.2, ENST00000379549.6
    Conserved Domains (2) summary
    smart00413
    Location:118200
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:2048
    Elf-1_N; Transcription factor protein N terminal
  2. NM_001276458.1NP_001263387.1  ETS-related transcription factor Elf-2 isoform 4

    See identical proteins and their annotated locations for NP_001263387.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate exon in place of the first three exons and compared to variant 1. Translation starts in the alternate exon, so the resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF256222, AK316455, BC034951, U43188
    Consensus CDS
    CCDS64062.1
    UniProtKB/Swiss-Prot
    Q15723
    UniProtKB/TrEMBL
    B7Z720
    Related
    ENSP00000426997.1, ENST00000510408.5
    Conserved Domains (2) summary
    smart00413
    Location:135217
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:2048
    Elf-1_N; Transcription factor protein N terminal
  3. NM_001276459.1NP_001263388.1  ETS-related transcription factor Elf-2 isoform 5

    See identical proteins and their annotated locations for NP_001263388.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate exon in place of the first three exons and lacks an alternate in-frame exon compared to variant 1. Translation starts in the alternate exon, so the resulting isoform (5) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AF256222, BC034951, BI770157, U43188
    UniProtKB/Swiss-Prot
    Q15723
    Conserved Domains (2) summary
    pfam00178
    Location:109188
    Ets; Ets-domain
    pfam12310
    Location:2048
    Elf-1_N; Transcription factor protein N terminal
  4. NM_001331036.1NP_001317965.1  ETS-related transcription factor Elf-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AF256222, BC065025, BU621268, DA221737, U43188
    Consensus CDS
    CCDS82954.1
    UniProtKB/Swiss-Prot
    Q15723
    Related
    ENSP00000368868.1, ENST00000379550.5
    Conserved Domains (2) summary
    smart00413
    Location:207289
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:3108
    Elf-1_N; Transcription factor protein N terminal
  5. NM_006874.3NP_006865.1  ETS-related transcription factor Elf-2 isoform 2

    See identical proteins and their annotated locations for NP_006865.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon in place of the first three exons and uses an alternate in-frame splice junction at the 5' end of an internal exon compared to variant 1. Translation starts in the alternate exon, so the resulting isoform (2) has a shorter and distinct N-terminus and contains an alternate internal segment compared to isoform 1.
    Source sequence(s)
    BC034951, U43188
    Consensus CDS
    CCDS3745.1
    UniProtKB/Swiss-Prot
    Q15723
    Related
    ENSP00000351458.2, ENST00000358635.7
    Conserved Domains (2) summary
    smart00413
    Location:147229
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:2048
    Elf-1_N; Transcription factor protein N terminal
  6. NM_201999.2NP_973728.1  ETS-related transcription factor Elf-2 isoform 1

    See identical proteins and their annotated locations for NP_973728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF256222, DR000047, U43188
    Consensus CDS
    CCDS3744.1
    UniProtKB/Swiss-Prot
    Q15723
    Conserved Domains (2) summary
    smart00413
    Location:195277
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:3108
    Elf-1_N; Transcription factor protein N terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    139057258..139177218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453920.1XP_024309688.1  ETS-related transcription factor Elf-2 isoform X4

    Conserved Domains (1) summary
    smart00413
    Location:103185
    ETS; erythroblast transformation specific domain
  2. XM_005262805.2XP_005262862.1  ETS-related transcription factor Elf-2 isoform X3

    Conserved Domains (2) summary
    pfam00178
    Location:169248
    Ets; Ets-domain
    pfam12310
    Location:3108
    Elf-1_N; Transcription factor protein N terminal
  3. XM_005262804.2XP_005262861.1  ETS-related transcription factor Elf-2 isoform X1

    See identical proteins and their annotated locations for XP_005262861.1

    UniProtKB/Swiss-Prot
    Q15723
    Related
    ENSP00000377782.1, ENST00000394235.6
    Conserved Domains (2) summary
    smart00413
    Location:195277
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:3108
    Elf-1_N; Transcription factor protein N terminal
  4. XM_006714128.2XP_006714191.1  ETS-related transcription factor Elf-2 isoform X2

    See identical proteins and their annotated locations for XP_006714191.1

    Conserved Domains (2) summary
    pfam00178
    Location:181260
    Ets; Ets-domain
    pfam12310
    Location:3108
    Elf-1_N; Transcription factor protein N terminal
  5. XM_024453927.1XP_024309695.1  ETS-related transcription factor Elf-2 isoform X7

    Conserved Domains (1) summary
    smart00413
    Location:62144
    ETS; erythroblast transformation specific domain
  6. XM_024453922.1XP_024309690.1  ETS-related transcription factor Elf-2 isoform X5

    Conserved Domains (1) summary
    smart00413
    Location:91173
    ETS; erythroblast transformation specific domain
  7. XM_024453924.1XP_024309692.1  ETS-related transcription factor Elf-2 isoform X6

    Conserved Domains (1) summary
    smart00413
    Location:74156
    ETS; erythroblast transformation specific domain
  8. XM_024453919.1XP_024309687.1  ETS-related transcription factor Elf-2 isoform X4

    Conserved Domains (1) summary
    smart00413
    Location:103185
    ETS; erythroblast transformation specific domain
  9. XM_024453925.1XP_024309693.1  ETS-related transcription factor Elf-2 isoform X7

    Conserved Domains (1) summary
    smart00413
    Location:62144
    ETS; erythroblast transformation specific domain
  10. XM_024453921.1XP_024309689.1  ETS-related transcription factor Elf-2 isoform X5

    Conserved Domains (1) summary
    smart00413
    Location:91173
    ETS; erythroblast transformation specific domain
  11. XM_024453923.1XP_024309691.1  ETS-related transcription factor Elf-2 isoform X6

    Conserved Domains (1) summary
    smart00413
    Location:74156
    ETS; erythroblast transformation specific domain
  12. XM_024453926.1XP_024309694.1  ETS-related transcription factor Elf-2 isoform X7

    Conserved Domains (1) summary
    smart00413
    Location:62144
    ETS; erythroblast transformation specific domain
  13. XM_024453918.1XP_024309686.1  ETS-related transcription factor Elf-2 isoform X4

    Conserved Domains (1) summary
    smart00413
    Location:103185
    ETS; erythroblast transformation specific domain
  14. XM_011531711.2XP_011530013.1  ETS-related transcription factor Elf-2 isoform X4

    See identical proteins and their annotated locations for XP_011530013.1

    Conserved Domains (1) summary
    smart00413
    Location:103185
    ETS; erythroblast transformation specific domain
  15. XM_011531714.2XP_011530016.1  ETS-related transcription factor Elf-2 isoform X8

    Conserved Domains (1) summary
    pfam00178
    Location:131
    Ets; Ets-domain
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