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EIF4E eukaryotic translation initiation factor 4E [ Homo sapiens (human) ]

Gene ID: 1977, updated on 5-May-2024

Summary

Official Symbol
EIF4Eprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 4Eprovided by HGNC
Primary source
HGNC:HGNC:3287
See related
Ensembl:ENSG00000151247 MIM:133440; AllianceGenome:HGNC:3287
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBP; EIF4F; AUTS19; EIF4E1; eIF-4E; EIF4EL1
Summary
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in testis (RPKM 13.1), thyroid (RPKM 12.0) and 25 other tissues See more
Orthologs
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Genomic context

Location:
4q23
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (98879276..98929133, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (102194230..102244088, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (99800427..99850284, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:99668606-99669156 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:99669157-99669707 Neighboring gene basic transcription factor 3 pseudogene 13 Neighboring gene uncharacterized LOC105377343 Neighboring gene Sharpr-MPRA regulatory region 12926 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:99813327-99813541 Neighboring gene tubulin folding cofactor A pseudogene 3 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:99850678-99851877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15579 Neighboring gene Putative protein FAM177A2 Neighboring gene RNA, U7 small nuclear 149 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Pr55(Gag) gag Expression of HIV-1 Gag requires eIF4E, eIF4G, and eIF4A (eIF4F) binding to the viral 5'UTR PubMed
Vpr vpr HIV-1 Vpr expression in HEK293 cells is sufficient to decrease the levels of phosphorylated eIF4E and 4E-BP1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC111573

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA 7-methylguanosine cap binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA cap binding TAS
Traceable Author Statement
more info
PubMed 
enables enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables eukaryotic initiation factor 4G binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA cap binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA cap binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of translation at postsynapse, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
part_of RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatoid body IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 4F complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of eukaryotic translation initiation factor 4F complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 4E
Names
eIF-4F 25 kDa subunit
eukaryotic translation initiation factor 4E-like 1
mRNA cap-binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047048.2 RefSeqGene

    Range
    6503..56360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130678.4NP_001124150.1  eukaryotic translation initiation factor 4E isoform 3

    See identical proteins and their annotated locations for NP_001124150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5'-terminal exon, which results in a different 5' UTR and use of an alternate translation start codon compared to variant 1. It encodes isoform 3, which has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC019131, AC093836, BC107715, DC388666
    Consensus CDS
    CCDS47109.1
    UniProtKB/TrEMBL
    Q32Q75, X5D7E3
    Related
    ENSP00000280892.6, ENST00000280892.10
    Conserved Domains (1) summary
    pfam01652
    Location:61217
    IF4E; Eukaryotic initiation factor 4E
  2. NM_001130679.3NP_001124151.1  eukaryotic translation initiation factor 4E isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2, which is longer than isoform 1.
    Source sequence(s)
    AC019131, AC093836, BM849222
    Consensus CDS
    CCDS54779.1
    UniProtKB/TrEMBL
    Q32Q75
    Related
    ENSP00000425561.1, ENST00000505992.1
    Conserved Domains (1) summary
    pfam01652
    Location:38228
    IF4E; Eukaryotic initiation factor 4E
  3. NM_001331017.2NP_001317946.1  eukaryotic translation initiation factor 4E isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and contains an alternate exon in its 5' coding region compared to variant 1. This variant represents translation initiation at an alternate start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the alternate start codon to encode an isoform (4) that has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC093836, BC035166, BY994926, M15353
    Consensus CDS
    CCDS82940.1
    UniProtKB/TrEMBL
    D6RBW1, Q32Q75
    Related
    ENSP00000423977.1, ENST00000504432.5
    Conserved Domains (1) summary
    cl02106
    Location:64242
    IF4E; Eukaryotic initiation factor 4E
  4. NM_001968.5NP_001959.1  eukaryotic translation initiation factor 4E isoform 1

    See identical proteins and their annotated locations for NP_001959.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (1).
    Source sequence(s)
    AC019131, AC093836, M15353
    Consensus CDS
    CCDS34031.1
    UniProtKB/Swiss-Prot
    B7Z6V1, D6RCQ6, P06730, Q96E95
    UniProtKB/TrEMBL
    Q32Q75
    Related
    ENSP00000389624.2, ENST00000450253.7
    Conserved Domains (1) summary
    pfam01652
    Location:38197
    IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    98879276..98929133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    102194230..102244088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)