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DPEP1 dipeptidase 1 [ Homo sapiens (human) ]

Gene ID: 1800, updated on 13-Feb-2019

Summary

Official Symbol
DPEP1provided by HGNC
Official Full Name
dipeptidase 1provided by HGNC
Primary source
HGNC:HGNC:3002
See related
Ensembl:ENSG00000015413 MIM:179780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDP; RDP; MBD1
Summary
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Biased expression in small intestine (RPKM 104.6), kidney (RPKM 102.2) and 3 other tissues See more
Orthologs

Genomic context

See DPEP1 in Genome Data Viewer
Location:
16q24.3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (89613308..89641540)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89679716..89707216)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 68 Neighboring gene ribosomal protein L13 Neighboring gene copine 7 Neighboring gene charged multivesicular body protein 1A Neighboring gene spermatogenesis associated 33 Neighboring gene long intergenic non-protein coding RNA 2166

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
NHGRI GWA Catalog

Pathways from BioSystems

  • Aflatoxin activation and detoxification, organism-specific biosystem (from REACTOME)
    Aflatoxin activation and detoxification, organism-specific biosystemAflatoxins are among the principal mycotoxins produced as secondary metabolites by the molds Aspergillus flavus and Aspergillus parasiticus that contaminate economically important food and feed crops...
  • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
    Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Eicosanoid Synthesis, organism-specific biosystem (from WikiPathways)
    Eicosanoid Synthesis, organism-specific biosystemIn biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or i...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
    Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
  • leukotriene biosynthesis, organism-specific biosystem (from BIOCYC)
    leukotriene biosynthesis, organism-specific biosystemLeukotrienes are made by cells of the immune system, mainly the mediators of inflammation like polymorphonuclear leukocytes, macrophages and mast cells. Cellular activation during inflammation leads ...
  • leukotriene biosynthesis, conserved biosystem (from BIOCYC)
    leukotriene biosynthesis, conserved biosystemLeukotrienes are proinflammatory metabolites of arachidonic acid that activate and amplify innate and adaptive immune responses. They also have roles in pathologic immune responses, mediating contrac...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GPI anchor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
dipeptidyl-peptidase activity IEA
Inferred from Electronic Annotation
more info
 
metallodipeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metalloexopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
modified amino acid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
antibiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular lactam catabolic process TAS
Traceable Author Statement
more info
PubMed 
cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to drug IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to nitric oxide ISS
Inferred from Sequence or Structural Similarity
more info
 
glutathione metabolic process TAS
Traceable Author Statement
more info
PubMed 
homocysteine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
leukotriene metabolic process TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell junction IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
dipeptidase 1
Names
dehydropeptidase-I
dipeptidase 1 (renal)
hRDP
microsomal dipeptidase
renal dipeptidase
testicular tissue protein Li 57
NP_001121613.1
NP_004404.1
XP_005256342.1
XP_005256343.1
XP_011521227.1
XP_016878498.1
XP_024305941.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128141.2NP_001121613.1  dipeptidase 1 precursor

    See identical proteins and their annotated locations for NP_001121613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate initial 5' UTR exon. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010538, BC017023, BM152944
    Consensus CDS
    CCDS10982.1
    UniProtKB/Swiss-Prot
    P16444
    UniProtKB/TrEMBL
    A0A140VJI3
    Related
    ENSP00000397313.1, ENST00000421184.5
    Conserved Domains (1) summary
    pfam01244
    Location:25352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  2. NM_004413.3NP_004404.1  dipeptidase 1 precursor

    See identical proteins and their annotated locations for NP_004404.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate initial 5' UTR exon. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC017023, J05257
    Consensus CDS
    CCDS10982.1
    UniProtKB/Swiss-Prot
    P16444
    UniProtKB/TrEMBL
    A0A140VJI3
    Related
    ENSP00000376807.3, ENST00000393092.7
    Conserved Domains (1) summary
    pfam01244
    Location:25352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    89613308..89641540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256285.5XP_005256342.1  dipeptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_005256342.1

    UniProtKB/Swiss-Prot
    P16444
    UniProtKB/TrEMBL
    A0A140VJI3
    Conserved Domains (1) summary
    pfam01244
    Location:25352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  2. XM_005256286.4XP_005256343.1  dipeptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_005256343.1

    UniProtKB/Swiss-Prot
    P16444
    UniProtKB/TrEMBL
    A0A140VJI3
    Related
    ENSP00000261615.4, ENST00000261615.5
    Conserved Domains (1) summary
    pfam01244
    Location:25352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  3. XM_017023009.1XP_016878498.1  dipeptidase 1 isoform X3

    Conserved Domains (1) summary
    pfam01244
    Location:25352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  4. XM_011522925.3XP_011521227.1  dipeptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_011521227.1

    UniProtKB/Swiss-Prot
    P16444
    UniProtKB/TrEMBL
    A0A140VJI3
    Conserved Domains (1) summary
    pfam01244
    Location:25352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  5. XM_024450173.1XP_024305941.1  dipeptidase 1 isoform X2

    Conserved Domains (1) summary
    pfam01244
    Location:5307
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
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