Format

Send to:

Choose Destination

DCT dopachrome tautomerase [ Homo sapiens (human) ]

Gene ID: 1638, updated on 21-Apr-2019

Summary

Official Symbol
DCTprovided by HGNC
Official Full Name
dopachrome tautomeraseprovided by HGNC
Primary source
HGNC:HGNC:2709
See related
Ensembl:ENSG00000080166 MIM:191275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRP-2; TYRP2
Expression
Restricted expression toward skin (RPKM 44.8) See more
Orthologs

Genomic context

See DCT in Genome Data Viewer
Location:
13q32.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (94437304..94549413, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (95091835..95131936, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene glypican 6 Neighboring gene RNA, 5S ribosomal pseudogene 35 Neighboring gene GPC6 antisense RNA 1 Neighboring gene tRNA-Phe (anticodon GAA) 1-5 Neighboring gene TDP-glucose 4,6-dehydratase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Melanin biosynthesis, organism-specific biosystem (from REACTOME)
    Melanin biosynthesis, organism-specific biosystemMelanin biosynthesis takes place in specialized cells called melanocytes, within membrane-bound organelles referred to as melanosomes. Melanosomes are transferred via dendrites to surrounding keratin...
  • Melanogenesis, organism-specific biosystem (from KEGG)
    Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Melanogenesis, conserved biosystem (from KEGG)
    Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
    Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...
  • Tyrosine metabolism, organism-specific biosystem (from KEGG)
    Tyrosine metabolism, organism-specific biosystem
    Tyrosine metabolism
  • Tyrosine metabolism, conserved biosystem (from KEGG)
    Tyrosine metabolism, conserved biosystem
    Tyrosine metabolism

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
copper ion binding TAS
Traceable Author Statement
more info
PubMed 
dopachrome isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell development IEA
Inferred from Electronic Annotation
more info
 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
melanin biosynthetic process TAS
Traceable Author Statement
more info
 
melanin biosynthetic process from tyrosine ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
melanosome ISS
Inferred from Sequence or Structural Similarity
more info
 
melanosome membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
L-dopachrome tautomerase
Names
DT
L-dopachrome Delta-isomerase
L-dopachrome isomerase
TRP2
dopachrome delta-isomerase
dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
tyrosinase related protein-2
tyrosine-related protein 2
NP_001123361.1
NP_001309111.1
NP_001309112.1
NP_001309113.1
NP_001309114.1
NP_001309115.1
NP_001913.2
XP_011519351.1
XP_016875890.1
XP_024305096.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129889.2NP_001123361.1  L-dopachrome tautomerase isoform 2 precursor

    See identical proteins and their annotated locations for NP_001123361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes two alternate in-frame exons and is predicted to encode a slightly longer protein isoform (2) compared to isoform 1.
    Source sequence(s)
    AL139318
    Consensus CDS
    CCDS45060.1
    UniProtKB/Swiss-Prot
    P40126
    Related
    ENSP00000392762.1, ENST00000446125.1
    Conserved Domains (1) summary
    pfam00264
    Location:180442
    Tyrosinase; Common central domain of tyrosinase
  2. NM_001322182.1NP_001309111.1  L-dopachrome tautomerase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL139318
    Conserved Domains (1) summary
    pfam00264
    Location:1298
    Tyrosinase; Common central domain of tyrosinase
  3. NM_001322183.1NP_001309112.1  L-dopachrome tautomerase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL139318
    Conserved Domains (1) summary
    pfam00264
    Location:1298
    Tyrosinase; Common central domain of tyrosinase
  4. NM_001322184.1NP_001309113.1  L-dopachrome tautomerase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL139318
    Conserved Domains (1) summary
    pfam00264
    Location:1298
    Tyrosinase; Common central domain of tyrosinase
  5. NM_001322185.1NP_001309114.1  L-dopachrome tautomerase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL139318
    Conserved Domains (1) summary
    pfam00264
    Location:1298
    Tyrosinase; Common central domain of tyrosinase
  6. NM_001322186.1NP_001309115.1  L-dopachrome tautomerase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL139318
    Conserved Domains (1) summary
    pfam00264
    Location:117346
    Tyrosinase; Common central domain of tyrosinase
  7. NM_001922.5NP_001913.2  L-dopachrome tautomerase isoform 1 precursor

    See identical proteins and their annotated locations for NP_001913.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the more abundant transcript.
    Source sequence(s)
    AL139318
    Consensus CDS
    CCDS9470.1
    UniProtKB/Swiss-Prot
    P40126
    Related
    ENSP00000366227.4, ENST00000377028.10
    Conserved Domains (1) summary
    pfam00264
    Location:180409
    Tyrosinase; Common central domain of tyrosinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    94437304..94549413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521049.2XP_011519351.1  L-dopachrome tautomerase isoform X1

    See identical proteins and their annotated locations for XP_011519351.1

    Conserved Domains (1) summary
    pfam00264
    Location:117346
    Tyrosinase; Common central domain of tyrosinase
  2. XM_024449328.1XP_024305096.1  L-dopachrome tautomerase isoform X2

    Conserved Domains (1) summary
    pfam00264
    Location:1298
    Tyrosinase; Common central domain of tyrosinase
  3. XM_017020401.2XP_016875890.1  L-dopachrome tautomerase isoform X3

RNA

  1. XR_002957452.1 RNA Sequence

Support Center