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CYP4A11 cytochrome P450 family 4 subfamily A member 11 [ Homo sapiens (human) ]

Gene ID: 1579, updated on 10-Dec-2024

Summary

Official Symbol
CYP4A11provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily A member 11provided by HGNC
Primary source
HGNC:HGNC:2642
See related
Ensembl:ENSG00000187048 MIM:601310; AllianceGenome:HGNC:2642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CP4Y; CYP4A2; CYP4AII; CYPIVA11
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
Expression
Biased expression in liver (RPKM 280.4) and kidney (RPKM 130.2) See more
Orthologs
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Genomic context

See CYP4A11 in Genome Data Viewer
Location:
1p33
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46929188..46941476, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46806597..46818885, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47394860..47407148, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily B member 1 Neighboring gene cytochrome P450 family 4 subfamily Z member 2, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47327255-47327861 Neighboring gene tubulin alpha pseudogene 8 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:47434192-47434383 Neighboring gene cytochrome P450 family 4 subfamily A member 26, pseudogene Neighboring gene cytochrome P450 family 4 subfamily X member 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47449029-47449836 Neighboring gene cytochrome P450 family 4 subfamily A member 43, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alkane 1-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables alkane 1-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arachidonate epoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arachidonate monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables arachidonate omega-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables leukotriene-B4 20-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables long-chain fatty acid omega-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monooxygenase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in arachidonate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in arachidonate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epoxygenase P450 pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid metabolic process TAS
Traceable Author Statement
more info
 
involved_in icosanoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in kidney development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lauric acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leukotriene B4 catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in leukotriene metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in omega-hydroxylase P450 pathway TAS
Traceable Author Statement
more info
 
involved_in oxylipin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of icosanoid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pressure natriuresis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in renal water homeostasis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sodium ion homeostasis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome P450 4A11
Names
20-HETE synthase
20-hydroxyeicosatetraenoic acid synthase
P450HL-omega
alkane-1 monooxygenase
cytochrome P-450HK-omega
cytochrome P450, family 4, subfamily A, polypeptide 11
cytochrome P450, subfamily IVA, polypeptide 11
cytochrome P450HL-omega
fatty acid omega-hydroxylase
lauric acid omega-hydroxylase
long-chain fatty acid omega-monooxygenase
NP_000769.2
NP_001306084.1
NP_001350516.1
XP_005270596.1
XP_016855954.1
XP_054190680.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007932.1 RefSeqGene

    Range
    5009..17297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000778.4NP_000769.2  cytochrome P450 4A11 isoform 1

    See identical proteins and their annotated locations for NP_000769.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL731892, CD014132, D26481, S67580
    Consensus CDS
    CCDS543.1
    UniProtKB/Swiss-Prot
    Q02928, Q06766, Q16865, Q16866, Q5VSP8, Q86SU6, Q8IWY5
    UniProtKB/TrEMBL
    Q16802
    Related
    ENSP00000311095.4, ENST00000310638.9
    Conserved Domains (1) summary
    pfam00067
    Location:52505
    p450; Cytochrome P450
  2. NM_001319155.2NP_001306084.1  cytochrome P450 4A11 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL731892, CD013974, L04751
    UniProtKB/TrEMBL
    Q16802
    Conserved Domains (1) summary
    pfam00067
    Location:52473
    p450; Cytochrome P450
  3. NM_001363587.2NP_001350516.1  cytochrome P450 4A11 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has multiple differences in the coding region compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL731892
    Consensus CDS
    CCDS85973.1
    UniProtKB/TrEMBL
    A5PL05, V9GZ77
    Related
    ENSP00000477495.1, ENST00000462347.5
    Conserved Domains (1) summary
    pfam00067
    Location:52407
    p450; Cytochrome P450

RNA

  1. NR_134988.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD013975, L04751
  2. NR_134989.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD013976, L04751
  3. NR_134990.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD013977, L04751
  4. NR_134991.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD013978, L04751
  5. NR_134992.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks four alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD013979, L04751
  6. NR_134993.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks three alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD013980, L04751
    Related
    ENST00000475477.5
  7. NR_134994.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD014132, L04751

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    46929188..46941476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000465.2XP_016855954.1  cytochrome P450 4A11 isoform X1

    UniProtKB/TrEMBL
    B4DPB8
  2. XM_005270539.1XP_005270596.1  cytochrome P450 4A11 isoform X2

    UniProtKB/TrEMBL
    A5PL05
    Conserved Domains (1) summary
    cl12078
    Location:52357
    p450; Cytochrome P450

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    46806597..46818885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334705.1XP_054190680.1  cytochrome P450 4A11 isoform X1

    UniProtKB/TrEMBL
    B4DPB8