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RDH10 retinol dehydrogenase 10 [ Homo sapiens (human) ]

Gene ID: 157506, updated on 15-Jun-2019

Summary

Official Symbol
RDH10provided by HGNC
Official Full Name
retinol dehydrogenase 10provided by HGNC
Primary source
HGNC:HGNC:19975
See related
Ensembl:ENSG00000121039 MIM:607599
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDR16C4
Summary
This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in kidney (RPKM 18.4), gall bladder (RPKM 13.9) and 24 other tissues See more
Orthologs

Genomic context

See RDH10 in Genome Data Viewer
Location:
8q21.11
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (73294602..73325285)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (74206837..74237520)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chromosome 8 open reading frame 89 Neighboring gene peroxiredoxin like 2A pseudogene 2 Neighboring gene RDH10 antisense RNA 1 Neighboring gene ribosomal protein L7 Neighboring gene uncharacterized LOC105375899 Neighboring gene STAU2 antisense RNA 1 Neighboring gene staufen double-stranded RNA binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADP-retinol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
retinol dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bud elongation involved in lung branching IEA
Inferred from Electronic Annotation
more info
 
ear development IEA
Inferred from Electronic Annotation
more info
 
embryonic camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic viscerocranium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
gonad development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
metanephros development IEA
Inferred from Electronic Annotation
more info
 
neural crest cell development IEA
Inferred from Electronic Annotation
more info
 
nose development IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of retinoic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
primary lung bud formation IEA
Inferred from Electronic Annotation
more info
 
retinal metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
retinoic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
retinol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
visual perception IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
retinol dehydrogenase 10
Names
retinol dehydrogenase 10 (all-trans)
short chain dehydrogenase/reductase family 16C member 4
NP_742034.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172037.5NP_742034.1  retinol dehydrogenase 10

    See identical proteins and their annotated locations for NP_742034.1

    Status: REVIEWED

    Source sequence(s)
    AC111149, AF456765, BC067131, BM472905, BM804062, BM979260, CD110145
    Consensus CDS
    CCDS6213.1
    UniProtKB/Swiss-Prot
    Q8IZV5
    UniProtKB/TrEMBL
    A0A024R7X6
    Related
    ENSP00000240285.5, ENST00000240285.10
    Conserved Domains (1) summary
    cd05339
    Location:38307
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    73294602..73325281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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