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CYP2F1 cytochrome P450 family 2 subfamily F member 1 [ Homo sapiens (human) ]

Gene ID: 1572, updated on 17-Jun-2019

Summary

Official Symbol
CYP2F1provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily F member 1provided by HGNC
Primary source
HGNC:HGNC:2632
See related
Ensembl:ENSG00000197446 MIM:124070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C2F1; CYP2F; CYPIIF1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See CYP2F1 in Genome Data Viewer
Location:
19q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41114292..41128381)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41620312..41634286)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily G member 2, pseudogene Neighboring gene cytochrome P450 family 2 subfamily A member 13 Neighboring gene cytochrome P450 family 2 subfamily T member 3, pseudogene Neighboring gene Sharpr-MPRA regulatory region 1789

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC126121

Gene Ontology Provided by GOA

Process Evidence Code Pubs
epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exogenous drug catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
naphthalene metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
naphthalene metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
trichloroethylene metabolic process IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome P450 2F1
Names
cytochrome P450, family 2, subfamily F, polypeptide 1
cytochrome P450, subfamily IIF, polypeptide 1
flavoprotein-linked monooxygenase
microsomal monooxygenase
xenobiotic monooxygenase
NP_000765.2
XP_011524853.1
XP_011524854.1
XP_011524855.1
XP_011524856.1
XP_011524857.1
XP_016881873.1
XP_016881874.1
XP_016881875.1
XP_016881876.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007930.1 RefSeqGene

    Range
    4985..18934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000774.5NP_000765.2  cytochrome P450 2F1 precursor

    See identical proteins and their annotated locations for NP_000765.2

    Status: REVIEWED

    Source sequence(s)
    BC109057, CB853363, DC413790
    Consensus CDS
    CCDS12572.1
    UniProtKB/Swiss-Prot
    P24903
    Related
    ENSP00000333534.2, ENST00000331105.7
    Conserved Domains (1) summary
    pfam00067
    Location:31488
    p450; Cytochrome P450

RNA

  1. NR_135528.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008962, AK316498, CB853363
    Related
    ENST00000532164.2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    41114292..41128381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526552.3XP_011524854.1  cytochrome P450 2F1 isoform X3

    See identical proteins and their annotated locations for XP_011524854.1

    Conserved Domains (1) summary
    pfam00067
    Location:31432
    p450; Cytochrome P450
  2. XM_011526551.3XP_011524853.1  cytochrome P450 2F1 isoform X3

    See identical proteins and their annotated locations for XP_011524853.1

    Conserved Domains (1) summary
    pfam00067
    Location:31432
    p450; Cytochrome P450
  3. XM_011526554.3XP_011524856.1  cytochrome P450 2F1 isoform X5

    Conserved Domains (1) summary
    pfam00067
    Location:1368
    p450; Cytochrome P450
  4. XM_017026385.1XP_016881874.1  cytochrome P450 2F1 isoform X2

  5. XM_011526553.2XP_011524855.1  cytochrome P450 2F1 isoform X4

    Conserved Domains (1) summary
    pfam00067
    Location:106453
    p450; Cytochrome P450
  6. XM_017026387.1XP_016881876.1  cytochrome P450 2F1 isoform X7

  7. XM_017026384.2XP_016881873.1  cytochrome P450 2F1 isoform X1

  8. XM_017026386.1XP_016881875.1  cytochrome P450 2F1 isoform X7

  9. XM_011526555.3XP_011524857.1  cytochrome P450 2F1 isoform X6

    Conserved Domains (1) summary
    pfam00067
    Location:106377
    p450; Cytochrome P450

RNA

  1. XR_935755.1 RNA Sequence

  2. XR_430190.3 RNA Sequence

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