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ADRB3 adrenoceptor beta 3 [ Homo sapiens (human) ]

Gene ID: 155, updated on 2-May-2024

Summary

Official Symbol
ADRB3provided by HGNC
Official Full Name
adrenoceptor beta 3provided by HGNC
Primary source
HGNC:HGNC:288
See related
Ensembl:ENSG00000188778 MIM:109691; AllianceGenome:HGNC:288
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BETA3AR
Summary
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.[provided by RefSeq, Oct 2019]
Expression
Biased expression in ovary (RPKM 4.0), placenta (RPKM 1.7) and 3 other tissues See more
Orthologs
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Genomic context

Location:
8p11.23
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (37962990..37966599, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (38239389..38242998, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37820508..37824117, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:37767897-37768396 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37773378-37773893 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37773894-37774410 Neighboring gene RNA, 7SL, cytoplasmic 709, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5273 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37792805-37793306 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:37797148-37797664 Neighboring gene glutamic-oxaloacetic transaminase 1 like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:37823116-37823850 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:37845776-37845966 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:37871736-37871907 Neighboring gene NANOG hESC enhancer GRCh37_chr8:37872816-37873317 Neighboring gene Sharpr-MPRA regulatory region 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:37892967-37893468 Neighboring gene eukaryotic translation initiation factor 4E binding protein 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:37911667-37911880 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37927359-37928086 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:37929540-37930265 Neighboring gene Sharpr-MPRA regulatory region 11218 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1253 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:37960345-37960633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19116 Neighboring gene ASH2 like, histone lysine methyltransferase complex subunit Neighboring gene RNA, U6 small nuclear 988, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ99960

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-3 adrenergic receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables beta-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables beta3-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta3-adrenergic receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to norepinephrine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in diet induced thermogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in eating behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in energy reserve metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
involved_in heat generation IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in negative regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NOT involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
beta-3 adrenergic receptor
Names
adrenergic, beta-3-, receptor
beta-3 adrenoceptor
beta-3 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011936.1 RefSeqGene

    Range
    5068..8677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000025.3NP_000016.1  beta-3 adrenergic receptor

    See identical proteins and their annotated locations for NP_000016.1

    Status: REVIEWED

    Source sequence(s)
    AC144573, BQ024407, DA904248, X70811
    Consensus CDS
    CCDS6099.1
    UniProtKB/Swiss-Prot
    P13945, Q4JFT4
    UniProtKB/TrEMBL
    A8KAG8, B8X6N0, B8X6N1
    Related
    ENSP00000343782.3, ENST00000345060.5
    Conserved Domains (2) summary
    cd14964
    Location:7395
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:51356
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    37962990..37966599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    38239389..38242998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)