U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ADRB3 adrenoceptor beta 3 [ Homo sapiens (human) ]

Gene ID: 155, updated on 9-Jun-2025
Official Symbol
ADRB3provided by HGNC
Official Full Name
adrenoceptor beta 3provided by HGNC
Primary source
HGNC:HGNC:288
See related
Ensembl:ENSG00000188778 MIM:109691; AllianceGenome:HGNC:288
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BETA3AR
Summary
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.[provided by RefSeq, Oct 2019]
Expression
Biased expression in ovary (RPKM 4.0), placenta (RPKM 1.7) and 3 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table
See ADRB3 in Genome Data Viewer
Location:
8p11.23
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (37962990..37966599, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (38239389..38242998, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37820508..37824117, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:37767897-37768396 Neighboring gene RNA, 7SL, cytoplasmic 709, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37773378-37773893 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37773894-37774410 Neighboring gene Sharpr-MPRA regulatory region 5273 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37792805-37793306 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:37797148-37797664 Neighboring gene glutamic-oxaloacetic transaminase 1 like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:37823116-37823850 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:37845776-37845966 Neighboring gene ribosomal protein L12 pseudogene 48 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:37871736-37871907 Neighboring gene NANOG hESC enhancer GRCh37_chr8:37872816-37873317 Neighboring gene Sharpr-MPRA regulatory region 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:37892967-37893468 Neighboring gene eukaryotic translation initiation factor 4E binding protein 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:37911667-37911880

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Polymorphism Trp64Arg of beta 3 adrenoreceptor gene: allelic frequencies and influence on insulin resistance in a multicenter study of Castilla-León. de Luis DA, et al. Nutr Hosp, 2010 Mar-Apr. PMID 20449541
  2. Relationship between Trp64Arg mutation in the β3-adrenergic receptor gene and metabolic syndrome: a seven-year follow-up study. Zhu LY, et al. Chin Med J (Engl), 2010 Sep. PMID 21034552
  3. TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle. Marti A, et al. Diabetes Obes Metab, 2002 Nov. PMID 12406043
  4. β-Adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder. Limberg BJ, et al. Cell Tissue Res, 2010 Nov. PMID 20953633, Free PMC Article
  5. A study on the relationship between genetic and environmental factors of type 2 diabetes mellitus in humans. Chen Y, et al. Zhonghua Yu Fang Yi Xue Za Zhi, 2002 May. PMID 12410955

See all (377) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association between rs4994 variant in beta3-Adrenergic receptor and obesity in Vietnamese preschool-age children, independent of eating behaviors.
    Title: Association between rs4994 variant in β3-Adrenergic receptor and obesity in Vietnamese preschool-age children, independent of eating behaviors.
  2. Urinary beta 3-adrenoceptor as a diagnostic biomarker for overactive bladder in women.
    Title: Urinary beta 3-adrenoceptor as a diagnostic biomarker for overactive bladder in women.
  3. Effects of the Trp64Arg Polymorphism in the ADRB3 Gene on Body Composition, Cardiorespiratory Fitness, and Physical Activity in Healthy Adults.
    Title: Effects of the Trp64Arg Polymorphism in the ADRB3 Gene on Body Composition, Cardiorespiratory Fitness, and Physical Activity in Healthy Adults.
  4. The beta3 adrenoceptor in proliferative retinopathies: "Cinderella" steps out of its family shadow.
    Title: The β3 adrenoceptor in proliferative retinopathies: "Cinderella" steps out of its family shadow.
  5. beta3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure.
    Title: β3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure.
  6. Association of an ADRB3 Variant with Coronary Artery Disease Within the Chinese Han Population: Construction of a Predictive Nomogram Model.
    Title: Association of an ADRB3 Variant with Coronary Artery Disease Within the Chinese Han Population: Construction of a Predictive Nomogram Model.
  7. Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose Multipotent Mesenchymal Stromal Cells: A Novel Mechanism of Obesity-Driven Hypertension.
    Title: Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose Multipotent Mesenchymal Stromal Cells: A Novel Mechanism of Obesity-Driven Hypertension.
  8. Development of a genetic risk score for obesity predisposition evaluation.
    Title: Development of a genetic risk score for obesity predisposition evaluation.
  9. The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis.
    Title: The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis.
  10. ADRB3 induces mobilization and inhibits differentiation of both breast cancer cells and myeloid-derived suppressor cells.
    Title: ADRB3 induces mobilization and inhibits differentiation of both breast cancer cells and myeloid-derived suppressor cells.
Submit: New GeneRIF Correction See all GeneRIFs (228)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Inherited obesity
MedGen: C4054476 OMIM: 601665 GeneReviews: Not available
Compare labs

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ99960

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-3 adrenergic receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables beta3-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta3-adrenergic receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables epinephrine binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to norepinephrine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables norepinephrine binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within diet induced thermogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in eating behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in energy reserve metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within heat generation IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in negative regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
  
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
NOT involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to cold IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
beta-3 adrenergic receptor
Names
adrenergic, beta-3-, receptor
beta-3 adrenoceptor
beta-3 adrenoreceptor

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011936.1 RefSeqGene

    Range
    5068..8677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000025.3 → NP_000016.1  beta-3 adrenergic receptor

    See identical proteins and their annotated locations for NP_000016.1

    Status: REVIEWED

    Source sequence(s)
    AC144573, BQ024407, DA904248, X70811
    Consensus CDS
    CCDS6099.1
    UniProtKB/Swiss-Prot
    P13945, Q4JFT4
    UniProtKB/TrEMBL
    A8KAG8, B8X6N0, B8X6N1
    Related
    ENSP00000343782.3, ENST00000345060.5
    Conserved Domains (2) summary
    cd14964
    Location:73 → 95
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:51 → 356
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    37962990..37966599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    38239389..38242998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13945.3 GenPept UniProtKB/Swiss-Prot:P13945

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous