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PDIK1L PDLIM1 interacting kinase 1 like [ Homo sapiens (human) ]

Gene ID: 149420, updated on 5-Jul-2025
Official Symbol
PDIK1Lprovided by HGNC
Official Full Name
PDLIM1 interacting kinase 1 likeprovided by HGNC
Primary source
HGNC:HGNC:18981
See related
Ensembl:ENSG00000175087 MIM:610785; AllianceGenome:HGNC:18981
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLIK1L; STK35L2
Summary
Predicted to enable protein kinase activity. Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of G2/MI transition of meiotic cell cycle. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in thyroid (RPKM 7.2), bone marrow (RPKM 4.5) and 25 other tissues See more
Orthologs
mouse all
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See PDIK1L in Genome Data Viewer
Location:
1p36.11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26111162..26125555)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25948595..25962987)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26437653..26452046)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376910 Neighboring gene Sharpr-MPRA regulatory region 4919 Neighboring gene tripartite motif containing 63 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26405707-26405883 Neighboring gene VISTA enhancer hs2271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 473 Neighboring gene Sharpr-MPRA regulatory region 12487 Neighboring gene Sharpr-MPRA regulatory region 4586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26480925-26481654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26481655-26482384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26482385-26483114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26483115-26483844 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26490758-26491327 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26494780-26494935 Neighboring gene family with sequence similarity 110 member D Neighboring gene chromosome 1 open reading frame 230

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Molecular cloning and characterization of a novel human kinase gene, PDIK1L. Guo L, et al. J Genet, 2003 Apr-Aug. PMID 14631099
  2. Phosphorylation of the 26 kDa TNF precursor in monocytic cells and in transfected HeLa cells. Pócsik E, et al. J Inflamm, 1995. PMID 8597870
  3. SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia. Polyanskaya SA, et al. Cell Rep, 2022 Jan 11. PMID 35021089, Free PMC Article
  4. Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. Goyal P, et al. PLoS One, 2009 Sep 16. PMID 19756140, Free PMC Article
  5. Human ORFeome version 1.1: a platform for reverse proteomics. Rual JF, et al. Genome Res, 2004 Oct. PMID 15489335, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.
    Title: SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
serine/threonine-protein kinase PDIK1L
Names
casein kinase
NP_001230461.1
NP_001230462.1
NP_690048.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243532.2 → NP_001230461.1  serine/threonine-protein kinase PDIK1L

    See identical proteins and their annotated locations for NP_001230461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL391650, AL834290, BU742621, CV024336, DA221039, DB233669
    Consensus CDS
    CCDS274.1
    UniProtKB/Swiss-Prot
    B2R777, D3DPK2, Q5T2I0, Q8N165, Q8NDB3
    Related
    ENSP00000480635.1, ENST00000619836.4
    Conserved Domains (1) summary
    cd13977
    Location:7 → 331
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

  2. NM_001243533.2 → NP_001230462.1  serine/threonine-protein kinase PDIK1L

    See identical proteins and their annotated locations for NP_001230462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AF411102, AL391650, BU742621, DB227864
    Consensus CDS
    CCDS274.1
    UniProtKB/Swiss-Prot
    B2R777, D3DPK2, Q5T2I0, Q8N165, Q8NDB3
    Related
    ENSP00000363389.4, ENST00000374271.8
    Conserved Domains (1) summary
    cd13977
    Location:7 → 331
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

  3. NM_152835.5 → NP_690048.1  serine/threonine-protein kinase PDIK1L

    See identical proteins and their annotated locations for NP_690048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK312872, AL391650, AL834290, BU742621
    Consensus CDS
    CCDS274.1
    UniProtKB/Swiss-Prot
    B2R777, D3DPK2, Q5T2I0, Q8N165, Q8NDB3
    Related
    ENSP00000363387.1, ENST00000374269.2
    Conserved Domains (1) summary
    cd13977
    Location:7 → 331
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    26111162..26125555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    25948595..25962987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N165.1 GenPept UniProtKB/Swiss-Prot:Q8N165

Gene LinkOut

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