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ODF4 outer dense fiber of sperm tails 4 [ Homo sapiens (human) ]

Gene ID: 146852, updated on 2-Nov-2024

Summary

Official Symbol
ODF4provided by HGNC
Official Full Name
outer dense fiber of sperm tails 4provided by HGNC
Primary source
HGNC:HGNC:19056
See related
Ensembl:ENSG00000184650 MIM:610097; AllianceGenome:HGNC:19056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT134; CT136; OPPO1
Summary
This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Restricted expression toward testis (RPKM 5.1) See more
Orthologs
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Genomic context

See ODF4 in Genome Data Viewer
Location:
17p13.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8339840..8346046)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8246077..8252283)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8243158..8249364)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA69 Neighboring gene uncharacterized LOC124903916 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8257795-8258364 Neighboring gene uncharacterized LOC100128288 Neighboring gene KRAB-A domain containing 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8279661-8280212 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8285969-8286686 Neighboring gene ribosomal protein L26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC138215, MGC138219

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
outer dense fiber protein 4
Names
cancer/testis antigen 134
cancer/testis antigen 136
hOPPO1
outer dense fiber 4
outer dense fiber of sperm tails protein 4
testis-specific protein oppo 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319953.2NP_001306882.1  outer dense fiber protein 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC135178
    Consensus CDS
    CCDS82069.1
    UniProtKB/TrEMBL
    C3TX97
    Related
    ENSP00000461942.1, ENST00000584943.1
  2. NM_153007.5NP_694552.2  outer dense fiber protein 4 isoform 1

    See identical proteins and their annotated locations for NP_694552.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB081120, AC135178
    Consensus CDS
    CCDS11140.1
    UniProtKB/Swiss-Prot
    Q2M2E3, Q8J021
    Related
    ENSP00000331086.2, ENST00000328248.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    8339840..8346046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    8246077..8252283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)