CRY1 cryptochrome circadian regulator 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CRY1provided by HGNC
Official Full Name: cryptochrome circadian regulator 1provided by HGNC
Primary source: HGNC:HGNC:2384
See related: Ensembl:ENSG00000008405 MIM:601933; AllianceGenome:HGNC:2384
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DSPD; PHLL1
Summary: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]
Expression: Broad expression in testis (RPKM 23.5), thyroid (RPKM 10.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q23.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (106991364..107093549, complement)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (106954997..107057182, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (107385142..107487327, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circadian Gene cry Controls Tumorigenesis through Modulation of Myc Accumulation in Glioblastoma Cells.
Title: Circadian Gene cry Controls Tumorigenesis through Modulation of Myc Accumulation in Glioblastoma Cells.
Cryptochrome 1 is modulated by blue light in human keratinocytes and exerts positive impact on human hair growth.
Title: Cryptochrome 1 is modulated by blue light in human keratinocytes and exerts positive impact on human hair growth.
CRY1 Regulates Chemoresistance in Association With NANOG by Inhibiting Apoptosis via STAT3 Pathway in Patients With Cervical Cancer.
Title: CRY1 Regulates Chemoresistance in Association With NANOG by Inhibiting Apoptosis via STAT3 Pathway in Patients With Cervical Cancer.
Variants of the cry 1 gene may influence the effect of fat intake on resting metabolic rate in women with overweight of obesity: a cross-sectional study.
Title: Variants of the cry 1 gene may influence the effect of fat intake on resting metabolic rate in women with overweight of obesity: a cross-sectional study.
An observational study investigating the CRY1Delta11 variant associated with delayed sleep-wake patterns and circadian metabolic output.
Title: An observational study investigating the CRY1Δ11 variant associated with delayed sleep-wake patterns and circadian metabolic output.
The molecular clock gene cryptochrome 1 (CRY1) and its role in cluster headache.
Title: The molecular clock gene cryptochrome 1 (CRY1) and its role in cluster headache.
RNF38 inhibits osteosarcoma cell proliferation by binding to CRY1.
Title: RNF38 inhibits osteosarcoma cell proliferation by binding to CRY1.
Circadian clock protein CRY1 prevents paclitaxelinduced senescence of bladder cancer cells by promoting p53 degradation.
Title: Circadian clock protein CRY1 prevents paclitaxel‑induced senescence of bladder cancer cells by promoting p53 degradation.
Analysis of Evolution and Ethnic Diversity at Glucose-Associated SNPs of Circadian Clock-Related Loci with Cryptochrome 1, Cryptochrome 2, and Melatonin receptor 1B.
Title: Analysis of Evolution and Ethnic Diversity at Glucose-Associated SNPs of Circadian Clock-Related Loci with Cryptochrome 1, Cryptochrome 2, and Melatonin receptor 1B.
Assessment of Selected Clock Proteins (CLOCK and CRY1) and Their Relationship with Biochemical, Anthropometric, and Lifestyle Parameters in Hypertensive Patients.
Title: Assessment of Selected Clock Proteins (CLOCK and CRY1) and Their Relationship with Biochemical, Anthropometric, and Lifestyle Parameters in Hypertensive Patients.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Delayed sleep phase syndrome, susceptibility to MedGen: C3279991 OMIM: 614163 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH79737 (e-PCR)
- UniSTS:87879

RH93858 (e-PCR)
- UniSTS:85601

AB074458 (e-PCR)
- UniSTS:480113

CRY1_1267 (e-PCR)
- UniSTS:277130

G54218 (e-PCR)
- UniSTS:109485

Homology

Homologs of the CRY1 gene: The CRY1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, and frog.
Orthologs from Annotation Pipeline: 426 organisms have orthologs with human gene CRY1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables DNA (6-4) photolyase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables E-box binding	IEA Inferred from Electronic Annotation more info
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables blue light photoreceptor activity	NAS Non-traceable Author Statement more info	PubMed
NOT enables deoxyribodipyrimidine photo-lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage induced protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in blue light signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in entrainment of circadian clock by photoperiod	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in entrainment of circadian clock by photoperiod	ISS Inferred from Sequence or Structural Similarity more info
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid storage	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glucocorticoid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glucocorticoid secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription, DNA-templated	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription, DNA-templated	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-chromophore linkage	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA damage checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to glucagon	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to light stimulus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cryptochrome-1

Names: cryptochrome 1 (photolyase-like); cryptochrome circadian clock 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004075.5 → NP_004066.1 cryptochrome-1

See identical proteins and their annotated locations for NP_004066.1

Status: REVIEWED

Source sequence(s)

AK290552, BC017466, BJ993835, DB454192

Consensus CDS

CCDS9112.1

UniProtKB/Swiss-Prot

Q16526

UniProtKB/TrEMBL

A2I2P0

Related

ENSP00000008527.5, ENST00000008527.10

Conserved Domains (2) summary

COG0415
Location:6 → 491

PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]

pfam03441
Location:288 → 486

FAD_binding_7; FAD binding domain of DNA photolyase