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CRY1 cryptochrome circadian regulator 1 [ Homo sapiens (human) ]

Gene ID: 1407, updated on 3-Nov-2019

Summary

Official Symbol
CRY1provided by HGNC
Official Full Name
cryptochrome circadian regulator 1provided by HGNC
Primary source
HGNC:HGNC:2384
See related
Ensembl:ENSG00000008405 MIM:601933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DSPD; PHLL1
Summary
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]
Expression
Broad expression in testis (RPKM 23.5), thyroid (RPKM 10.6) and 25 other tissues See more
Orthologs

Genomic context

See CRY1 in Genome Data Viewer
Location:
12q23.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (106991364..107093872, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (107385142..107487635, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9924 Neighboring gene transmembrane protein 263 Neighboring gene mitochondrial transcription termination factor 2 Neighboring gene Sharpr-MPRA regulatory region 11431 Neighboring gene SET pseudogene 7

Genomic regions, transcripts, and products

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
    BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
  • Circadian Clock, organism-specific biosystem (from REACTOME)
    Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
  • Circadian rhythm, organism-specific biosystem (from KEGG)
    Circadian rhythm, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
  • Circadian rhythm, conserved biosystem (from KEGG)
    Circadian rhythm, conserved biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystem (from WikiPathways)
    Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
  • Melatonin metabolism and effects, organism-specific biosystem (from WikiPathways)
    Melatonin metabolism and effects, organism-specific biosystemMelatonin is an important regulator of circadian rythmus and influences also insulin secretion, immune function, retinal function and neuroprotection. The synthesis starts with the amino acid tryptop...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT DNA (6-4) photolyase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding TAS
Traceable Author Statement
more info
PubMed 
E-box binding IEA
Inferred from Electronic Annotation
more info
 
blue light photoreceptor activity NAS
Non-traceable Author Statement
more info
PubMed 
NOT deoxyribodipyrimidine photo-lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
nuclear hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage induced protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
blue light signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid storage IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of glucocorticoid receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of glucocorticoid secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-chromophore linkage IEA
Inferred from Electronic Annotation
more info
 
regulation of DNA damage checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
response to activity ISS
Inferred from Sequence or Structural Similarity
more info
 
response to glucagon ISS
Inferred from Sequence or Structural Similarity
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to light stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cryptochrome-1
Names
cryptochrome 1 (photolyase-like)
cryptochrome circadian clock 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004075.5NP_004066.1  cryptochrome-1

    See identical proteins and their annotated locations for NP_004066.1

    Status: REVIEWED

    Source sequence(s)
    AK290552, BC017466, BJ993835, DB454192
    Consensus CDS
    CCDS9112.1
    UniProtKB/Swiss-Prot
    Q16526
    UniProtKB/TrEMBL
    A2I2P0
    Related
    ENSP00000008527.5, ENST00000008527.10
    Conserved Domains (2) summary
    COG0415
    Location:6491
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam03441
    Location:288486
    FAD_binding_7; FAD binding domain of DNA photolyase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    106991364..107093872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448845.1XP_024304613.1  cryptochrome-1 isoform X2

    Conserved Domains (2) summary
    pfam03441
    Location:260458
    FAD_binding_7; FAD binding domain of DNA photolyase
    cl27275
    Location:24463
    DNA_photolyase; DNA photolyase
  2. XM_024448844.1XP_024304612.1  cryptochrome-1 isoform X1

    Conserved Domains (2) summary
    COG0415
    Location:6491
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam03441
    Location:288486
    FAD_binding_7; FAD binding domain of DNA photolyase
  3. XM_017018832.2XP_016874321.1  cryptochrome-1 isoform X3

    Conserved Domains (2) summary
    pfam00875
    Location:21125
    DNA_photolyase; DNA photolyase
    pfam03441
    Location:185458
    FAD_binding_7; FAD binding domain of DNA photolyase
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