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CPD carboxypeptidase D [ Homo sapiens (human) ]

Gene ID: 1362, updated on 15-Apr-2019

Summary

Official Symbol
CPDprovided by HGNC
Official Full Name
carboxypeptidase Dprovided by HGNC
Primary source
HGNC:HGNC:2301
See related
Ensembl:ENSG00000108582 MIM:603102
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP180
Summary
The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 44.8), gall bladder (RPKM 23.6) and 24 other tissues See more
Orthologs

Genomic context

See CPD in Genome Data Viewer
Location:
17q11.2
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (30378924..30469657)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (28705942..28796675)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transmembrane and immunoglobulin domain containing 1 Neighboring gene RNA, U6 small nuclear 990, pseudogene Neighboring gene golgi SNAP receptor complex member 1 Neighboring gene arachidonate 12-lipoxygenase pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with CPD; predicted interaction to be within the Golgi PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Clathrin derived vesicle budding, organism-specific biosystem (from REACTOME)
    Clathrin derived vesicle budding, organism-specific biosystemThere at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the cl...
  • Golgi Associated Vesicle Biogenesis, organism-specific biosystem (from REACTOME)
    Golgi Associated Vesicle Biogenesis, organism-specific biosystemProteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell ...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • trans-Golgi Network Vesicle Budding, organism-specific biosystem (from REACTOME)
    trans-Golgi Network Vesicle Budding, organism-specific biosystemAfter passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membran...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
carboxypeptidase D
Names
metallocarboxypeptidase D
NP_001186704.1
NP_001295.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199775.1NP_001186704.1  carboxypeptidase D isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region and uses an alternate start codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC006050, AK316409, CA436219
    Consensus CDS
    CCDS56025.1
    UniProtKB/Swiss-Prot
    O75976
    Related
    ENSP00000444443.2, ENST00000543464.6
    Conserved Domains (4) summary
    cd03863
    Location:249544
    M14_CPD_II; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain II subgroup
    cd06245
    Location:685963
    M14_CPD_III; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain III subgroup
    cd11308
    Location:548623
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:3132
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  2. NM_001304.5NP_001295.2  carboxypeptidase D isoform 1 precursor

    See identical proteins and their annotated locations for NP_001295.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC006050, AC090685, BC045624, CA436219
    Consensus CDS
    CCDS11257.1
    UniProtKB/Swiss-Prot
    O75976
    Related
    ENSP00000225719.4, ENST00000225719.9
    Conserved Domains (4) summary
    cd03863
    Location:496791
    M14_CPD_II; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain II subgroup
    cd03868
    Location:58379
    M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup
    cd06245
    Location:9321210
    M14_CPD_III; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain III subgroup
    cd11308
    Location:795870
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    30378924..30469657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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