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ADM adrenomedullin [ Homo sapiens (human) ]

Gene ID: 133, updated on 5-Mar-2024

Summary

Official Symbol
ADMprovided by HGNC
Official Full Name
adrenomedullinprovided by HGNC
Primary source
HGNC:HGNC:259
See related
Ensembl:ENSG00000148926 MIM:103275; AllianceGenome:HGNC:259
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AM; PAMP
Summary
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
Expression
Broad expression in placenta (RPKM 66.2), fat (RPKM 27.8) and 18 other tissues See more
Orthologs
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Genomic context

See ADM in Genome Data Viewer
Location:
11p15.4
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (10305073..10307397)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (10389576..10391900)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (10326620..10328944)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene SET binding factor 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:10004023-10005222 Neighboring gene glutamate-ammonia ligase pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:10065715-10066914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:10098213-10098818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4430 Neighboring gene G protein subunit gamma 10 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3143 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3147 Neighboring gene Sharpr-MPRA regulatory region 210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3149 Neighboring gene Sharpr-MPRA regulatory region 6386 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:10361038-10361538 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:10361539-10362039 Neighboring gene uncharacterized LOC100130460 Neighboring gene VISTA enhancer hs2289 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:10375005-10375536 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:10375537-10376067 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:10388109-10388608 Neighboring gene Sharpr-MPRA regulatory region 7754 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:10413861-10414740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:10430364-10430864 Neighboring gene RNA, U6atac small nuclear 33, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:10430865-10431365 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:10437608-10437821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3151 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:10500293-10500792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:10509586-10510490 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:10521616-10522209 Neighboring gene adenosine monophosphate deaminase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.
EBI GWAS Catalog
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
EBI GWAS Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
EBI GWAS Catalog
Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables adrenomedullin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adrenomedullin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adrenomedullin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adrenomedullin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in androgen metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in branching involved in labyrinthine layer morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in developmental growth IEA
Inferred from Electronic Annotation
more info
 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of heart rate IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of heart rate IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of progesterone biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of systemic arterial blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of the force of heart contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of urine volume IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to insulin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to starvation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in vascular associated smooth muscle cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in vasculogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pro-adrenomedullin
Names
preproadrenomedullin
proadrenomedullin N-20 terminal peptide

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001124.3NP_001115.1  pro-adrenomedullin precursor

    See identical proteins and their annotated locations for NP_001115.1

    Status: REVIEWED

    Source sequence(s)
    BQ021632, D14874, HY105655
    Consensus CDS
    CCDS7801.1
    UniProtKB/Swiss-Prot
    B2R793, D3DQV3, P35318, Q6FGW2
    Related
    ENSP00000278175.5, ENST00000278175.10
    Conserved Domains (1) summary
    pfam00214
    Location:1151
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    10305073..10307397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    10389576..10391900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)