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PHB2 prohibitin 2 [ Homo sapiens (human) ]

Gene ID: 11331, updated on 3-Mar-2019

Summary

Official Symbol
PHB2provided by HGNC
Official Full Name
prohibitin 2provided by HGNC
Primary source
HGNC:HGNC:30306
See related
Ensembl:ENSG00000215021 MIM:610704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAP; REA; p22; hBAP; Bap37; BCAP37; PNAS-141
Expression
Ubiquitous expression in ovary (RPKM 111.2), duodenum (RPKM 62.9) and 25 other tissues See more
Orthologs

Genomic context

See PHB2 in Genome Data Viewer
Location:
12p13.31
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (6965352..6970753, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7074515..7079981, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene MIR200C and MIR141 host gene Neighboring gene microRNA 200c Neighboring gene microRNA 141 Neighboring gene small Cajal body-specific RNA 12 Neighboring gene EMG1 N1-specific pseudouridine methyltransferase Neighboring gene lysophosphatidylcholine acyltransferase 3 Neighboring gene ribosomal protein L37 pseudogene 20

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify prohibitin 2 (PHB2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Envelope surface glycoprotein gp160, precursor env The C-terminal cytoplasmic domain (Env-CT) of HIV-1 Env specifically binds to the Phb1/Phb2 complex. Strong binding is dependent on Env residues 790-800. L799R/L800Q double mutation in Env severely inhibits its binding to the Phb1/Phb2 complex PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with prohibitin 2 (PHB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify prohibitin 2 (PHB2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify prohibitin 2 (PHB2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify prohibitin 2 (PHB2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117268

Gene Ontology Provided by GOA

Function Evidence Code Pubs
amide binding IPI
Inferred from Physical Interaction
more info
PubMed 
estrogen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
 
mammary gland branching involved in thelarche IEA
Inferred from Electronic Annotation
more info
 
mitochondrial calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of intracellular estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mammary gland epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell cycle G1/S phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
NOT regulation of complement activation IDA
Inferred from Direct Assay
more info
PubMed 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
sister chromatid cohesion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prohibitin-2
Names
B-cell associated protein
B-cell receptor-associated protein BAP37
D-prohibitin
repressor of estrogen receptor activity

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144831.1NP_001138303.1  prohibitin-2 isoform 1

    See identical proteins and their annotated locations for NP_001138303.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC110322
    Consensus CDS
    CCDS53741.1
    UniProtKB/Swiss-Prot
    Q99623
    Related
    ENSP00000441875.1, ENST00000535923.5
    Conserved Domains (1) summary
    cd03401
    Location:40235
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
  2. NM_001267700.1NP_001254629.1  prohibitin-2 isoform 3

    See identical proteins and their annotated locations for NP_001254629.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AF150962, AK298217, BC110322, U47924
    Consensus CDS
    CCDS58207.1
    UniProtKB/Swiss-Prot
    Q99623
    Related
    ENSP00000412856.1, ENST00000440277.5
    Conserved Domains (1) summary
    cd03401
    Location:40203
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    6965352..6970753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_242980.3 RNA Sequence

    Related
    ENST00000543465.5
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