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RPP14 ribonuclease P/MRP subunit p14 [ Homo sapiens (human) ]

Gene ID: 11102, updated on 20-Mar-2019

Summary

Official Symbol
RPP14provided by HGNC
Official Full Name
ribonuclease P/MRP subunit p14provided by HGNC
Primary source
HGNC:HGNC:30327
See related
Ensembl:ENSG00000163684 MIM:606112
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P14
Summary
This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in thyroid (RPKM 4.8), kidney (RPKM 4.8) and 25 other tissues See more
Orthologs

Genomic context

See RPP14 in Genome Data Viewer
Location:
3p14.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (58306245..58320193)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (58291972..58305920)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986091 Neighboring gene abhydrolase domain containing 6 Neighboring gene hydroxyacyl-thioester dehydratase type 2 Neighboring gene uncharacterized LOC105377106 Neighboring gene PX domain containing serine/threonine kinase like Neighboring gene pyruvate dehydrogenase E1 beta subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystem (from REACTOME)
    Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • rRNA processing, organism-specific biosystem (from REACTOME)
    rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
  • rRNA processing in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
    rRNA processing in the nucleus and cytosol, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
  • tRNA processing, organism-specific biosystem (from REACTOME)
    tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
  • tRNA processing in the nucleus, organism-specific biosystem (from REACTOME)
    tRNA processing in the nucleus, organism-specific biosystemGenes encoding transfer RNAs are transcribed in the nucleus by RNA polymerase III. (Distinct processes of transcription and processing also occur in mitochondria.) The initial transcripts, pre-tRNAs,...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31508

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
contributes_to ribonuclease P activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
tRNA 5'-leader removal IDA
Inferred from Direct Assay
more info
PubMed 
tRNA 5'-leader removal TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
multimeric ribonuclease P complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ribonuclease P protein subunit p14
Names
ribonuclease P/MRP 14kDa subunit
NP_001092253.1
NP_008973.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098783.2NP_001092253.1  ribonuclease P protein subunit p14

    See identical proteins and their annotated locations for NP_001092253.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC098479, CN354601, DC360931
    Consensus CDS
    CCDS2888.1
    UniProtKB/Swiss-Prot
    O95059
    Related
    ENSP00000412894.2, ENST00000445193.7
    Conserved Domains (1) summary
    pfam01900
    Location:35108
    RNase_P_Rpp14; Rpp14/Pop5 family
  2. NM_007042.4NP_008973.1  ribonuclease P protein subunit p14

    See identical proteins and their annotated locations for NP_008973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC098479, BC002441, DC360931
    Consensus CDS
    CCDS2888.1
    UniProtKB/Swiss-Prot
    O95059
    Related
    ENSP00000295959.5, ENST00000295959.9
    Conserved Domains (1) summary
    pfam01900
    Location:35108
    RNase_P_Rpp14; Rpp14/Pop5 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    58306245..58320193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_049755.1: Suppressed sequence

    Description
    NR_049755.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
  2. NR_049756.1: Suppressed sequence

    Description
    NR_049756.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
  3. NR_049757.1: Suppressed sequence

    Description
    NR_049757.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
  4. NR_049758.1: Suppressed sequence

    Description
    NR_049758.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
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