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KLK11 kallikrein related peptidase 11 [ Homo sapiens (human) ]

Gene ID: 11012, updated on 21-Apr-2019

Summary

Official Symbol
KLK11provided by HGNC
Official Full Name
kallikrein related peptidase 11provided by HGNC
Primary source
HGNC:HGNC:6359
See related
Ensembl:ENSG00000167757 MIM:604434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLSP; PRSS20
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
Expression
Biased expression in esophagus (RPKM 58.7), skin (RPKM 44.2) and 7 other tissues See more
Orthologs

Genomic context

See KLK11 in Genome Data Viewer
Location:
19q13.41
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (51022231..51028034, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51525487..51531290, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 9 Neighboring gene kallikrein related peptidase 10 Neighboring gene kallikrein related peptidase 12 Neighboring gene kallikrein related peptidase 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33060

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type peptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 

General protein information

Preferred Names
kallikrein-11
Names
hK11
hippostasin
serine protease 20
trypsin-like protease

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136032.3NP_001129504.1  kallikrein-11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001129504.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' terminal exon, which results in a downstream translation start codon, compared to variant 2. The encoded isoform (1) has a shorter N-terminus than isoform 2, and is preferentially expressed in brain. Variants 1 and 4 encode the same isoform 1.
    Source sequence(s)
    AB259014, BG697071
    Consensus CDS
    CCDS12819.1
    UniProtKB/Swiss-Prot
    Q9UBX7
    UniProtKB/TrEMBL
    A0A1R3UDR5
    Related
    ENSP00000413958.2, ENST00000453757.8
    Conserved Domains (1) summary
    smart00020
    Location:21243
    Tryp_SPc; Trypsin-like serine protease
  2. NM_001167605.1NP_001161077.1  kallikrein-11 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001161077.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' terminal exon, which results in a downstream translation start codon, and has an alternate splice junction in the coding region, compared to variant 2. The encoded isoform (3) has a shorter N-terminus and an additional internal segment, compared to isoform 2.
    Source sequence(s)
    AB078780, BC022068
    Consensus CDS
    CCDS54297.1
    UniProtKB/Swiss-Prot
    Q9UBX7
    Related
    ENSP00000375680.2, ENST00000391804.7
    Conserved Domains (2) summary
    smart00020
    Location:21268
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:22271
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_006853.2NP_006844.1  kallikrein-11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006844.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 5' terminal exon, which results in a downstream translation start codon, compared to variant 2. The encoded isoform (1) has a shorter N-terminus than isoform 2, and is preferentially expressed in brain. Variants 1 and 4 encode the same isoform 1.
    Source sequence(s)
    BC022068
    Consensus CDS
    CCDS12819.1
    UniProtKB/Swiss-Prot
    Q9UBX7
    UniProtKB/TrEMBL
    A0A1R3UDR5
    Related
    ENSP00000324269.6, ENST00000319720.11
    Conserved Domains (1) summary
    smart00020
    Location:21243
    Tryp_SPc; Trypsin-like serine protease
  4. NM_144947.2NP_659196.1  kallikrein-11 isoform 2

    See identical proteins and their annotated locations for NP_659196.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2) which is preferentially expressed in prostate. This variant represents use of an mammalian interspersed repeat (MIR) alternate promoter and exon sequence. (PMID: 14550626)
    Source sequence(s)
    AB041036, BC022068, DB457266
    Consensus CDS
    CCDS12818.1
    UniProtKB/Swiss-Prot
    Q9UBX7
    Related
    ENSP00000473047.1, ENST00000594768.5
    Conserved Domains (2) summary
    smart00020
    Location:53275
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:54278
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    51022231..51028034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526369.1XP_011524671.1  kallikrein-11 isoform X1

    UniProtKB/Swiss-Prot
    Q9UBX7
    Conserved Domains (2) summary
    smart00020
    Location:53300
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:54303
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_005258439.3XP_005258496.1  kallikrein-11 isoform X3

    Conserved Domains (2) summary
    smart00020
    Location:47134
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:45137
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_011526372.2XP_011524674.1  kallikrein-11 isoform X2

    See identical proteins and their annotated locations for XP_011524674.1

    UniProtKB/Swiss-Prot
    Q9UBX7
    Conserved Domains (2) summary
    smart00020
    Location:21268
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:22271
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. XM_011526371.2XP_011524673.1  kallikrein-11 isoform X2

    See identical proteins and their annotated locations for XP_011524673.1

    UniProtKB/Swiss-Prot
    Q9UBX7
    Conserved Domains (2) summary
    smart00020
    Location:21268
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:22271
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  5. XM_011526370.2XP_011524672.1  kallikrein-11 isoform X2

    See identical proteins and their annotated locations for XP_011524672.1

    UniProtKB/Swiss-Prot
    Q9UBX7
    Conserved Domains (2) summary
    smart00020
    Location:21268
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:22271
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  6. XM_011526373.1XP_011524675.1  kallikrein-11 isoform X2

    See identical proteins and their annotated locations for XP_011524675.1

    UniProtKB/Swiss-Prot
    Q9UBX7
    Conserved Domains (2) summary
    smart00020
    Location:21268
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:22271
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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