Format

Send to:

Choose Destination

IL24 interleukin 24 [ Homo sapiens (human) ]

Gene ID: 11009, updated on 13-Feb-2019

Summary

Official Symbol
IL24provided by HGNC
Official Full Name
interleukin 24provided by HGNC
Primary source
HGNC:HGNC:11346
See related
Ensembl:ENSG00000162892 MIM:604136
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C49A; FISP; MDA7; MOB5; ST16; IL10B
Summary
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 12.3), spleen (RPKM 9.6) and 6 other tissues See more
Orthologs

Genomic context

See IL24 in Genome Data Viewer
Location:
1q32.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (206897404..206904139)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207070630..207077484)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene interleukin 20 Neighboring gene uncharacterized LOC105372879 Neighboring gene ribosomal protein L13a pseudogene 8 Neighboring gene Fc fragment of IgM receptor Neighboring gene polymeric immunoglobulin receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of interleukin 24 (IL24) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • IL23-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL23-mediated signaling events, organism-specific biosystem
    IL23-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-19, 20, 22, 24, organism-specific biosystem (from REACTOME)
    Interleukin-19, 20, 22, 24, organism-specific biosystemThe interleukin-20 (IL20) subfamily comprises IL19, IL-20, IL-22, IL-24 and IL-26. They are members of the larger IL-10 family, but have been grouped together based on their usage of common receptor ...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
serine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-24
Names
IL-4-induced secreted protein
melanocyte-associated Mda-7
melanoma differentiation-associated gene 7 protein
suppression of tumorigenicity 16 (melanoma differentiation)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029565.1 RefSeqGene

    Range
    5001..11697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001185156.1NP_001172085.1  interleukin-24 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001172085.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is 1 aa longer than isoform 1.
    Source sequence(s)
    AY641441, BC009681, BP222545
    Consensus CDS
    CCDS53465.1
    UniProtKB/Swiss-Prot
    Q13007
    Related
    ENSP00000375795.3, ENST00000391929.7
    Conserved Domains (1) summary
    cl02501
    Location:74201
    IL10; Interleukin 10
  2. NM_001185157.1NP_001172086.1  interleukin-24 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001172086.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as IL-24 delE5) uses an alternate in-frame splice site in the 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1.
    Source sequence(s)
    AY641441, BP222545
    Consensus CDS
    CCDS53466.1
    UniProtKB/Swiss-Prot
    Q13007
    Related
    ENSP00000356060.3, ENST00000367093.3
  3. NM_001185158.1NP_001172087.1  interleukin-24 isoform 5

    See identical proteins and their annotated locations for NP_001172087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as mda-7s) lacks two alternate coding exons, which results in a frameshift in the central and 3' coding regions, compared to variant 1. The encoded isoform (5, also known as MDA-7S) shares the same N-terminus but has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AY641441, BP222545, BP222651
    Consensus CDS
    CCDS73021.1
    UniProtKB/Swiss-Prot
    Q13007
    Related
    ENSP00000484900.1, ENST00000611909.4
  4. NM_006850.3NP_006841.1  interleukin-24 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006841.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AY641441, BP222545, U16261
    Consensus CDS
    CCDS1471.1
    UniProtKB/Swiss-Prot
    Q13007
    Related
    ENSP00000294984.2, ENST00000294984.6
    Conserved Domains (1) summary
    cl02501
    Location:73200
    IL10; Interleukin 10

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    206897404..206904139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000121.1XP_016855610.1  interleukin-24 isoform X1

    Conserved Domains (1) summary
    cl02501
    Location:46173
    IL10; Interleukin 10
  2. XM_011509101.2XP_011507403.1  interleukin-24 isoform X1

    See identical proteins and their annotated locations for XP_011507403.1

    Conserved Domains (1) summary
    cl02501
    Location:46173
    IL10; Interleukin 10

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181339.1: Suppressed sequence

    Description
    NM_181339.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Support Center