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CKAP4 cytoskeleton associated protein 4 [ Homo sapiens (human) ]

Gene ID: 10970, updated on 9-Jun-2025
Official Symbol
CKAP4provided by HGNC
Official Full Name
cytoskeleton associated protein 4provided by HGNC
Primary source
HGNC:HGNC:16991
See related
Ensembl:ENSG00000136026 MIM:618595; AllianceGenome:HGNC:16991
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p63; CLIMP63; CLIMP-63; ERGIC-63
Summary
Enables RNA binding activity. Located in several cellular components, including lipid droplet; nuclear speck; and rough endoplasmic reticulum. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in bone marrow (RPKM 41.9), placenta (RPKM 30.9) and 25 other tissues See more
Orthologs
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See CKAP4 in Genome Data Viewer
Location:
12q23.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (106237881..106248020, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (106200876..106211009, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (106631659..106641798, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NUAK family kinase 1 Neighboring gene uncharacterized LOC124903007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106523693-106524442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106524443-106525192 Neighboring gene Sharpr-MPRA regulatory region 11062 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:106526214-106527056 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106527057-106527900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106527901-106528743 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:106531161-106531662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:106534054-106534673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106541977-106542476 Neighboring gene thyroid hormone receptor interactor 11 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106581756-106582590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106605939-106606439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4815 Neighboring gene uncharacterized LOC124903008 Neighboring gene RNA, U7 small nuclear 94 pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. CKAP4 Regulates Cell Migration via the Interaction with and Recycling of Integrin. Osugi Y, et al. Mol Cell Biol, 2019 Aug 15. PMID 31160493, Free PMC Article
  2. How many lives does CLIMP-63 have? Sandoz PA, et al. Biochem Soc Trans, 2015 Apr. PMID 25849921, Free PMC Article
  3. Expression of cytoskeleton-associated protein 4 is associated with poor prognosis and metastasis in nasopharyngeal carcinoma. Cai M, et al. Exp Biol Med (Maywood), 2023 Jun. PMID 37208923, Free PMC Article
  4. Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules. Vedrenne C, et al. Mol Biol Cell, 2005 Apr. PMID 15703217, Free PMC Article
  5. CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy. Kimura H, et al. Clin Cancer Res, 2019 Mar 15. PMID 30610103

See all (269) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The clinical significance and diagnostic value of serum Dickkopf1 and CKAP4 levels in patients with gastric cancer: a prospective study.
    Title: The clinical significance and diagnostic value of serum Dickkopf1 and CKAP4 levels in patients with gastric cancer: a prospective study.
  2. Expression of cytoskeleton-associated protein 4 is associated with poor prognosis and metastasis in nasopharyngeal carcinoma.
    Title: Expression of cytoskeleton-associated protein 4 is associated with poor prognosis and metastasis in nasopharyngeal carcinoma.
  3. Cytoskeleton-associated protein 4 (CKAP4) promotes malignant progression of human gliomas through inhibition of the Hippo signaling pathway.
    Title: Cytoskeleton-associated protein 4 (CKAP4) promotes malignant progression of human gliomas through inhibition of the Hippo signaling pathway.
  4. Plasmalemma vesicle-associated protein promotes angiogenesis in cholangiocarcinoma via the DKK1/CKAP4/PI3K signaling pathway.
    Title: Plasmalemma vesicle-associated protein promotes angiogenesis in cholangiocarcinoma via the DKK1/CKAP4/PI3K signaling pathway.
  5. DKK1 activates noncanonical NF-kappaB signaling via IL-6-induced CKAP4 receptor in multiple myeloma.
    Title: DKK1 activates noncanonical NF-κB signaling via IL-6-induced CKAP4 receptor in multiple myeloma.
  6. Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondria contact sites.
    Title: Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondria contact sites.
  7. The RBP1-CKAP4 axis activates oncogenic autophagy and promotes cancer progression in oral squamous cell carcinoma.
    Title: The RBP1-CKAP4 axis activates oncogenic autophagy and promotes cancer progression in oral squamous cell carcinoma.
  8. p63 overexpression in the epidermis of spiny keratoderma.
    Title: p63 overexpression in the epidermis of spiny keratoderma.
  9. Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP6.
    Title: Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP6.
  10. CKAP4 was secreted with small extracellular vesicles (SEVs) from pancreatic ductal adenocarcinoma (PDAC) cells, and the SEVs exhibited the characteristics of exosomes. The secretion of CKAP4-containing exosomes was mediated by DKK1-dependent endocytosis routes and required exosome biogenesis molecules. The serum CKAP4 levels were higher in patients with PDAC than healthy control individuals.
    Title: CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with cytoskeleton-associated protein 4 (CKAP4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with cytoskeleton-associated protein 4 (CKAP4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC99554

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in lamellar body TAS
Traceable Author Statement
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in rough endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in specific granule membrane TAS
Traceable Author Statement
more info
  
Preferred Names
cytoskeleton-associated protein 4
Names
63 kDa membrane protein
63-kDa cytoskeleton-linking membrane protein
transmembrane protein (63kD), endoplasmic reticulum/Golgi intermediate compartment
type-II transmembrane protein p63

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006825.4 → NP_006816.2  cytoskeleton-associated protein 4

    See identical proteins and their annotated locations for NP_006816.2

    Status: VALIDATED

    Source sequence(s)
    AC079174, X69910
    Consensus CDS
    CCDS9103.1
    UniProtKB/Swiss-Prot
    Q07065, Q504S5, Q53ES6
    UniProtKB/TrEMBL
    B3KVX6
    Related
    ENSP00000367265.4, ENST00000378026.5
    Conserved Domains (2) summary
    TIGR00344
    Location:487 → 560
    alaS; alanine--tRNA ligase
    TIGR02168
    Location:149 → 459
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    106237881..106248020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    106200876..106211009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07065.2 GenPept UniProtKB/Swiss-Prot:Q07065

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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