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LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 [ Homo sapiens (human) ]

Gene ID: 10894, updated on 18-May-2019

Summary

Official Symbol
LYVE1provided by HGNC
Official Full Name
lymphatic vessel endothelial hyaluronan receptor 1provided by HGNC
Primary source
HGNC:HGNC:14687
See related
Ensembl:ENSG00000133800 MIM:605702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HAR; XLKD1; LYVE-1; CRSBP-1
Summary
This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 141.7), adrenal (RPKM 68.8) and 14 other tissues See more
Orthologs

Genomic context

See LYVE1 in Genome Data Viewer
Location:
11p15.4
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (10557866..10568818, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (10578712..10590365, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MT-RNR2 like 8 Neighboring gene microRNA 4485 Neighboring gene ring finger protein 141 Neighboring gene MRVI1 antisense RNA 1 Neighboring gene murine retrovirus integration site 1 homolog Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
    Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
  • Hyaluronan metabolism, organism-specific biosystem (from REACTOME)
    Hyaluronan metabolism, organism-specific biosystemHyaluronan (hyaluronic acid, hyaluronate or HA) is an anionic glycosaminoglycan (GAG) distributed widely throughout connective, epithelial, and neural tissues and most abundant in the extracellular m...
  • Hyaluronan uptake and degradation, organism-specific biosystem (from REACTOME)
    Hyaluronan uptake and degradation, organism-specific biosystemHyaluronan (HA) turnover can occur locally at the tissue of origin, where it is taken up by cells to be degraded, or released into the lymphatic and vascular systems, where it can be eliminated by th...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hyaluronic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
cell-matrix adhesion TAS
Traceable Author Statement
more info
PubMed 
hyaluronan catabolic process TAS
Traceable Author Statement
more info
 
response to wounding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
lymphatic vessel endothelial hyaluronic acid receptor 1
Names
cell surface retention sequence binding protein-1
extracellular link domain-containing 1
extracellular link domain-containing protein 1
hyaluronic acid receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006691.4NP_006682.2  lymphatic vessel endothelial hyaluronic acid receptor 1 precursor

    See identical proteins and their annotated locations for NP_006682.2

    Status: REVIEWED

    Source sequence(s)
    AC009532, AY358925, CA449932
    Consensus CDS
    CCDS7804.1
    UniProtKB/Swiss-Prot
    Q9Y5Y7
    UniProtKB/TrEMBL
    B2R672
    Related
    ENSP00000256178.3, ENST00000256178.7
    Conserved Domains (1) summary
    cd03516
    Location:34174
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    10557866..10568818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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