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AHCYL1 adenosylhomocysteinase like 1 [ Homo sapiens (human) ]

Gene ID: 10768, updated on 5-May-2024

Summary

Official Symbol
AHCYL1provided by HGNC
Official Full Name
adenosylhomocysteinase like 1provided by HGNC
Primary source
HGNC:HGNC:344
See related
Ensembl:ENSG00000168710 MIM:607826; AllianceGenome:HGNC:344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA
Summary
The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in brain (RPKM 81.1), duodenum (RPKM 50.1) and 25 other tissues See more
Orthologs
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Genomic context

See AHCYL1 in Genome Data Viewer
Location:
1p13.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (109984765..110023742)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (109994896..110033874)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110527387..110566364)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1768 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:110407495-110408040 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:110420113-110420301 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110422869-110423369 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110423473-110424313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110424314-110425153 Neighboring gene CRISPRi-validated cis-regulatory element chr1.7635 Neighboring gene Sharpr-MPRA regulatory region 12342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110453680-110454180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110454181-110454681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110473698-110474646 Neighboring gene colony stimulating factor 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110502441-110503012 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110503013-110503582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1458 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:110560640-110561839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1459 Neighboring gene uncharacterized LOC105378895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1166 Neighboring gene striatin interacting protein 1 Neighboring gene ALX homeobox 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat modulates IRBIT expression in neuron cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
NOT enables adenosylhomocysteinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
S-adenosylhomocysteine hydrolase-like protein 1
Names
DC-expressed AHCY-like molecule
IP(3)Rs binding protein released with IP(3)
S-adenosyl homocysteine hydrolase homolog
S-adenosyl-L-homocysteine hydrolase 2
adenosylhomocysteinase 2
adoHcyase 2
dendritic cell expressed AHCY-like protein
epididymis secretory sperm binding protein
inositol 1,4,5-trisphosphate receptor-binding protein
protein phosphatase 1, regulatory subunit 78
putative adenosylhomocysteinase 2
NP_001229602.1
NP_001229603.1
NP_001229604.1
NP_001229605.1
NP_006612.2
XP_011538837.1
XP_047296068.1
XP_054189912.1
XP_054189913.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029182.2 RefSeqGene

    Range
    5002..43979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242673.2NP_001229602.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_001229602.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AL772411
    Consensus CDS
    CCDS55620.1
    UniProtKB/TrEMBL
    Q2NKW8
    Related
    ENSP00000377238.4, ENST00000393614.8
    Conserved Domains (1) summary
    smart00996
    Location:59482
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  2. NM_001242674.2NP_001229603.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_001229603.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AA427939, AL772411, BK005417
    Consensus CDS
    CCDS55620.1
    UniProtKB/TrEMBL
    Q2NKW8
    Conserved Domains (1) summary
    smart00996
    Location:59482
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  3. NM_001242675.2NP_001229604.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_001229604.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AA427939, AK316110, AL049954, AL772411, DC328766
    Consensus CDS
    CCDS55620.1
    UniProtKB/TrEMBL
    Q2NKW8
    Related
    ENSP00000352092.3, ENST00000359172.3
    Conserved Domains (1) summary
    smart00996
    Location:59482
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  4. NM_001242676.2NP_001229605.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_001229605.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AA427939, AK316110, AL772411, DC328766
    Consensus CDS
    CCDS55620.1
    UniProtKB/TrEMBL
    Q2NKW8
    Conserved Domains (1) summary
    smart00996
    Location:59482
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  5. NM_006621.7NP_006612.2  S-adenosylhomocysteine hydrolase-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_006612.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL772411
    Consensus CDS
    CCDS818.1
    UniProtKB/Swiss-Prot
    B4E168, O43865, Q2TAJ6, Q502W8, Q5VSM0, Q6P171, Q96PK4, Q9UG84
    UniProtKB/TrEMBL
    A0A024R0A8, A0A384N6B4, Q2NKW8
    Related
    ENSP00000358814.5, ENST00000369799.10
    Conserved Domains (1) summary
    smart00996
    Location:106529
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    109984765..110023742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540535.3XP_011538837.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

    UniProtKB/TrEMBL
    Q2NKW8
    Conserved Domains (2) summary
    smart00996
    Location:106489
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    PRK05476
    Location:104489
    PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
  2. XM_047440112.1XP_047296068.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    109994896..110033874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333937.1XP_054189912.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

  2. XM_054333938.1XP_054189913.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X2