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GNA13 G protein subunit alpha 13 [ Homo sapiens (human) ]

Gene ID: 10672, updated on 27-Nov-2024

Summary

Official Symbol
GNA13provided by HGNC
Official Full Name
G protein subunit alpha 13provided by HGNC
Primary source
HGNC:HGNC:4381
See related
Ensembl:ENSG00000120063 MIM:604406; AllianceGenome:HGNC:4381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G13; HG1N
Summary
Enables G protein activity. Involved in G protein-coupled receptor signaling pathway. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 46.2), lymph node (RPKM 22.6) and 24 other tissues See more
Orthologs
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Genomic context

See GNA13 in Genome Data Viewer
Location:
17q24.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (65009289..65056740, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (65879260..65926708, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (63005407..63052858, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8856 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:62971753-62972623 Neighboring gene AMZ2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12605 Neighboring gene uncharacterized LOC124904044 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:63023805-63024744 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:63024745-63025684 Neighboring gene NANOG hESC enhancer GRCh37_chr17:63043783-63044416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8859 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:63059883-63060849 Neighboring gene uncharacterized LOC105371864 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8860 Neighboring gene uncharacterized LOC100507002

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common genetic variants and gene expression associated with white matter microstructure in the human brain.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC46138

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D5 dopamine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of vascular associated smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in brush border membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit alpha-13
Names
g alpha-13
guanine nucleotide binding protein (G protein), alpha 13
heterotrimeric guanine nucleotide-binding protein 1N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282425.2NP_001269354.1  guanine nucleotide-binding protein subunit alpha-13 isoform 2

    See identical proteins and their annotated locations for NP_001269354.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC037487, AK302400, AW298099
    Consensus CDS
    CCDS62302.1
    UniProtKB/TrEMBL
    B4DWV9
    Related
    ENSP00000439647.1, ENST00000541118.1
    Conserved Domains (1) summary
    cd00066
    Location:1276
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  2. NM_006572.6NP_006563.2  guanine nucleotide-binding protein subunit alpha-13 isoform 1

    See identical proteins and their annotated locations for NP_006563.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC037487, AF493902, AW298099, DC335364
    Consensus CDS
    CCDS11661.1
    UniProtKB/Swiss-Prot
    B2R977, B7Z7R0, F5H1G8, Q14344, Q8TD70
    UniProtKB/TrEMBL
    B4DWV9
    Related
    ENSP00000400717.2, ENST00000439174.7
    Conserved Domains (1) summary
    smart00275
    Location:29375
    G_alpha; G protein alpha subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    65009289..65056740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    65879260..65926708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)