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CXCR6 C-X-C motif chemokine receptor 6 [ Homo sapiens (human) ]

Gene ID: 10663, updated on 15-Apr-2019

Summary

Official Symbol
CXCR6provided by HGNC
Official Full Name
C-X-C motif chemokine receptor 6provided by HGNC
Primary source
HGNC:HGNC:16647
See related
Ensembl:ENSG00000172215 MIM:605163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BONZO; CD186; STRL33; TYMSTR
Expression
Broad expression in lymph node (RPKM 5.9), spleen (RPKM 4.9) and 19 other tissues See more
Orthologs

Genomic context

See CXCR6 in Genome Data Viewer
Location:
3p21.31
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (45940688..45948354)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (45984973..45989845)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene leucine zipper transcription factor like 1 Neighboring gene succinate dehydrogenase complex subunit D pseudogene 4 Neighboring gene C-C motif chemokine receptor 9 Neighboring gene FYVE and coiled-coil domain containing 1 Neighboring gene uncharacterized LOC105377063 Neighboring gene nuclear receptor binding factor 2 pseudogene 2 Neighboring gene X-C motif chemokine receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Macrophage-tropic HIV-1 can use CCR2b, and to a lesser extent CCR3, STRL33, and APJ, to infect cells; the V1/2 region of HIV-1 gp120 plays a more important role in governing the use of CCR2b, CCR3, STRL33, and APJ than for CXCR4 PubMed
env Some HIV-1 isolates are able to use CCR5/Bonzo as HIV-1 gp120 coreceptors for entry into cells PubMed
env Coexpression of DC-SIGN enables some HIV-1 isolates to use alternate HIV-1 gp120 coreceptors like STRL33 to infect cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
    Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-X-C chemokine binding IEA
Inferred from Electronic Annotation
more info
 
C-X-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
coreceptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral genome replication TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C-X-C chemokine receptor type 6
Names
CDw186
CXC-R6
CXCR-6
G protein-coupled receptor
G-protein coupled receptor STRL33
G-protein coupled receptor bonzo
chemokine (C-X-C motif) receptor 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006564.2NP_006555.1  C-X-C chemokine receptor type 6

    See identical proteins and their annotated locations for NP_006555.1

    Status: VALIDATED

    Source sequence(s)
    AC099782, Y13248
    Consensus CDS
    CCDS2735.1
    UniProtKB/Swiss-Prot
    O00574
    UniProtKB/TrEMBL
    A0N0N3
    Related
    ENSP00000304414.4, ENST00000304552.5
    Conserved Domains (1) summary
    cd15173
    Location:32299
    7tmA_CXCR6; CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    45940688..45948354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533290.2XP_011531592.1  C-X-C chemokine receptor type 6 isoform X1

    See identical proteins and their annotated locations for XP_011531592.1

    UniProtKB/Swiss-Prot
    O00574
    UniProtKB/TrEMBL
    A0N0N3
    Conserved Domains (1) summary
    cd15173
    Location:32299
    7tmA_CXCR6; CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_011533291.2XP_011531593.1  C-X-C chemokine receptor type 6 isoform X1

    See identical proteins and their annotated locations for XP_011531593.1

    UniProtKB/Swiss-Prot
    O00574
    UniProtKB/TrEMBL
    A0N0N3
    Related
    ENSP00000396218.1, ENST00000438735.1
    Conserved Domains (1) summary
    cd15173
    Location:32299
    7tmA_CXCR6; CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_005264809.2XP_005264866.1  C-X-C chemokine receptor type 6 isoform X1

    See identical proteins and their annotated locations for XP_005264866.1

    UniProtKB/Swiss-Prot
    O00574
    UniProtKB/TrEMBL
    A0N0N3
    Related
    ENSP00000396886.1, ENST00000457814.1
    Conserved Domains (1) summary
    cd15173
    Location:32299
    7tmA_CXCR6; CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors
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