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AKAP3 A-kinase anchoring protein 3 [ Homo sapiens (human) ]

Gene ID: 10566, updated on 11-Jun-2025
Official Symbol
AKAP3provided by HGNC
Official Full Name
A-kinase anchoring protein 3provided by HGNC
Primary source
HGNC:HGNC:373
See related
Ensembl:ENSG00000111254 MIM:604689; AllianceGenome:HGNC:373
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT82; SOB1; FSP95; PRKA3; HEL159; SPGF82; AKAP110; AKAP 110
Summary
This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]
Expression
Restricted expression toward testis (RPKM 61.9) See more
Orthologs
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See AKAP3 in Genome Data Viewer
Location:
12p13.32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (4615518..4649051, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (4622335..4655891, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (4724684..4758217, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:4647880-4648488 Neighboring gene RAD51 associated protein 1 Neighboring gene Sharpr-MPRA regulatory region 10040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5826 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 4 Neighboring gene coiled-coil domain containing 181 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5827 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:4737023-4738222 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:4739222-4740085 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:4742144-4742644 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:4742645-4743145 Neighboring gene RAB5A, member RAS oncogene family pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5828 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:4758050-4758705 Neighboring gene NADH:ubiquinone oxidoreductase subunit A9 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:4828687-4829682 Neighboring gene GALNT8 antisense upstream 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase A binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in acrosome reaction TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within blastocyst hatching IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor protein serine/threonine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of protein localization IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein localization IEA
Inferred from Electronic Annotation
more info
 
involved_in single fertilization TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in sperm fibrous sheath IEA
Inferred from Electronic Annotation
more info
 
is_active_in sperm fibrous sheath ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm principal piece IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
A-kinase anchor protein 3
Names
A kinase (PRKA) anchor protein 3
A-kinase anchor protein, 110kDa
Fibrous Sheath Protein of 95 kDa
cancer/testis antigen 82
epididymis luminal protein 159
epididymis secretory sperm binding protein
fibrousheathin I
fibrousheathin-1
protein kinase A binding protein AKAP 110
protein kinase A-anchoring protein 3
sperm oocyte-binding protein 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278309.2NP_001265238.2  A-kinase anchor protein 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC005832
    Consensus CDS
    CCDS8531.1
    UniProtKB/Swiss-Prot
    O75945, O75969, Q86X01, Q9UM61
    UniProtKB/TrEMBL
    B3KQD0, V9HWD4
    Related
    ENSP00000228850.1, ENST00000228850.6
    Conserved Domains (1) summary
    smart00807
    Location:5853
    AKAP_110; A-kinase anchor protein 110 kDa
  2. NM_006422.4NP_006413.4  A-kinase anchor protein 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC005832
    Consensus CDS
    CCDS8531.1
    UniProtKB/Swiss-Prot
    O75945, O75969, Q86X01, Q9UM61
    UniProtKB/TrEMBL
    B3KQD0, V9HWD4
    Related
    ENSP00000440994.1, ENST00000545990.6
    Conserved Domains (1) summary
    smart00807
    Location:5853
    AKAP_110; A-kinase anchor protein 110 kDa

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    4615518..4649051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    4622335..4655891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)