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CEL carboxyl ester lipase [ Homo sapiens (human) ]

Gene ID: 1056, updated on 21-Apr-2019

Summary

Official Symbol
CELprovided by HGNC
Official Full Name
carboxyl ester lipaseprovided by HGNC
Primary source
HGNC:HGNC:1848
See related
Ensembl:ENSG00000170835 MIM:114840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8
Summary
The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward pancreas (RPKM 14647.9) See more
Orthologs

Genomic context

See CEL in Genome Data Viewer
Location:
9q34.13
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (133061978..133071863)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135936741..135947250)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene general transcription factor IIIC subunit 5 Neighboring gene microRNA 6877 Neighboring gene uncharacterized LOC100996574 Neighboring gene carboxyl ester lipase pseudogene Neighboring gene ral guanine nucleotide dissociation stimulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Bile salt-stimulated lipase (BSSL) isolated from human milk binds to DC-SIGN, preventing HIV-1 gp120 from interacting with this receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
catalytic activity TAS
Traceable Author Statement
more info
PubMed 
heparin binding NAS
Non-traceable Author Statement
more info
PubMed 
hydrolase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sterol esterase activity NAS
Non-traceable Author Statement
more info
PubMed 
triglyceride lipase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cholesterol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
fatty acid catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
intestinal cholesterol absorption NAS
Non-traceable Author Statement
more info
PubMed 
intestinal lipid catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
lipid digestion TAS
Traceable Author Statement
more info
 
lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
pancreatic juice secretion IDA
Inferred from Direct Assay
more info
PubMed 
protein esterification NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bile salt-activated lipase
Names
bile salt-dependent lipase, oncofetal isoform
bucelipase
carboxyl ester hydrolase
carboxyl ester lipase (bile salt-stimulated lipase)
cholesterol esterase
fetoacinar pancreatic protein
lysophospholipase, pancreatic
sterol esterase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016394.1 RefSeqGene

    Range
    5001..14886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001807.5NP_001798.3  bile salt-activated lipase precursor

    Status: REVIEWED

    Source sequence(s)
    AF081673, AK299965, AL162417, BC042510
    Consensus CDS
    CCDS43896.1
    Related
    ENSP00000361151.4, ENST00000372080.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    133061978..133071863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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