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CIB1 calcium and integrin binding 1 [ Homo sapiens (human) ]

Gene ID: 10519, updated on 17-Feb-2019

Summary

Official Symbol
CIB1provided by HGNC
Official Full Name
calcium and integrin binding 1provided by HGNC
Primary source
HGNC:HGNC:16920
See related
Ensembl:ENSG00000185043 MIM:602293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIB; CIBP; KIP1; PRKDCIP; SIP2-28
Summary
This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Expression
Ubiquitous expression in colon (RPKM 49.7), adrenal (RPKM 37.7) and 25 other tissues See more
Orthologs

Genomic context

See CIB1 in Genome Data Viewer
Location:
15q26.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (90230245..90265759, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90773477..90808991, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 346, pseudogene Neighboring gene semaphorin 4B Neighboring gene ribosomal protein S12 pseudogene 26 Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene tubulin tyrosine ligase like 13, pseudogene Neighboring gene neugrin, neurite outgrowth associated Neighboring gene PERP, TP53 apoptosis effector pseudogene Neighboring gene nucleolar protein interacting with the FHA domain of MKI67 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 replication, specifically viral entry, requires CIB1 and CIB2 expression as shRNA knockdown of each impairs replication in Jurkat and primary CD4+ T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ras GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-dependent protein kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein membrane anchor IGI
Inferred from Genetic Interaction
more info
PubMed 
protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to nerve growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to tumor necrosis factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair TAS
Traceable Author Statement
more info
PubMed 
endomitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of megakaryocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of microtubule depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
platelet formation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of catalytic activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration involved in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell-matrix adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of male germ cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ischemia ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
 
thrombopoietin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular exosome HDA PubMed 
filopodium tip IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
vesicle HDA PubMed 

General protein information

Preferred Names
calcium and integrin-binding protein 1
Names
DNA-PK interaction protein
DNA-PKcs-interacting protein
DNA-dependent protein kinase interacting protein
SNK-interacting protein 2-28
calcium and integrin binding 1 (calmyrin)
testicular secretory protein Li 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277764.1NP_001264693.1  calcium and integrin-binding protein 1 isoform a

    See identical proteins and their annotated locations for NP_001264693.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longer isoform (a, also known as CIB1a).
    Source sequence(s)
    BG231771, CD622547, JQ246073
    Consensus CDS
    CCDS73781.1
    UniProtKB/Swiss-Prot
    Q99828
    Related
    ENSP00000479860.1, ENST00000612800.1
    Conserved Domains (3) summary
    cd00051
    Location:151218
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:149217
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:122172
    EF-hand_8; EF-hand domain pair
  2. NM_006384.3NP_006375.2  calcium and integrin-binding protein 1 isoform b

    See identical proteins and their annotated locations for NP_006375.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) uses an alternate splice site in the coding region, compared to variant a. The encoded isoform (b, also known as CIB1) is shorter, compared to isoform a.
    Source sequence(s)
    AA769426, CD622547, U82226
    Consensus CDS
    CCDS10360.1
    UniProtKB/Swiss-Prot
    Q99828
    UniProtKB/TrEMBL
    A0A140VK09
    Related
    ENSP00000333873.6, ENST00000328649.10
    Conserved Domains (1) summary
    cl25352
    Location:67182
    EFh_PEF; The penta-EF hand (PEF) family

RNA

  1. NR_102427.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) uses an alternate 5' exon and an alternate splice site in an internal exon, compared to variant a. This variant is represented as non-coding because it lacks the translation start site used in variant a and does not include a supported in-frame ORF.
    Source sequence(s)
    BG231771, BI520476, HY070030
  2. NR_102428.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) uses an alternate 5' exon and an alternate splice site in an internal exon, compared to variant a. This variant is represented as non-coding because it lacks the translation start site used in variant a and does not include a supported in-frame ORF.
    Source sequence(s)
    BG231771, BG759961

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    90230245..90265759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720375.2XP_006720438.1  calcium and integrin-binding protein 1 isoform X1

    Conserved Domains (3) summary
    cd00051
    Location:111178
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:109177
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:82132
    EF-hand_8; EF-hand domain pair
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