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CEBPB CCAAT enhancer binding protein beta [ Homo sapiens (human) ]

Gene ID: 1051, updated on 20-Apr-2019

Summary

Official Symbol
CEBPBprovided by HGNC
Official Full Name
CCAAT enhancer binding protein betaprovided by HGNC
Primary source
HGNC:HGNC:1834
See related
Ensembl:ENSG00000172216 MIM:189965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCF5; IL6DBP; NF-IL6; C/EBP-beta
Summary
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
Orthologs

Genomic context

See CEBPB in Genome Data Viewer
Location:
20q13.13
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (50190583..50192690)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48807120..48809227)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1275 Neighboring gene long intergenic non-protein coding RNA 1273 Neighboring gene CEBPB antisense RNA 1 Neighboring gene uncharacterized LOC107985386 Neighboring gene uncharacterized LOC105372656

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates C/EBPbeta expression in human mesenchymal stem cells PubMed
Tat tat The gene expression of CCAAT/enhancer binding protein beta is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells PubMed
tat The synergistic interaction between C/EBPbeta-2 and Tat with the subtype C LTR is observed in U-937 cells PubMed
tat Tat-C/EBPbeta association is mediated through cdk9, which phosphorylates C/EBPbeta PubMed
tat Specific C/EBP and NF-kappaB transcription factor binding elements within the IL-1beta promoter are involved in Tat regulation of IL-1beta production PubMed
tat Interaction between TGF-beta signaling proteins Smad-3 and Smad-4, and C/EBPbeta modulates basal and HIV-1 Tat-mediated transcription of the HIV-1 LTR promoter in astrocytes PubMed
tat Interaction of C/EBPbeta and HIV-1 Tat stimulates MCP-1 transcription in astrocytes PubMed
tat HIV-1 Tat induces an increase in C/EBPbeta binding activity through a direct binding interaction between Tat and C/EBPbeta that is mediated through the N-terminal, cysteine rich, and core regions of Tat (amino acids 1-47) PubMed
tat HIV-1 Tat upregulates IL-6 expression by transactivating the IL-6 promoter, an effect mediated through enhancement of CAAT enhancer-binding protein (C/EBP; nuclear factor-IL-6) DNA binding activity PubMed
tat HIV-1 Tat induces iNOS in human astroglia through the activation of NF-kappaB and C/EBPbeta, an effect that may participate in the pathogenesis of HIV-associated dementia PubMed
Vif vif NF-IL6 facilitates the reverse transcription of HIV-1 by binding to and inhibiting the antiviral cytidine deaminase APOBEC3G. A mutation in NF-IL6 at Ser-288 weakens its binding to APOBEC3G and strongly inhibits HIV-1 replication PubMed
Vpr vpr HIV-1 Vpr-induced retrotransposition of long interspersed element-1 depends on an AhR-MAPK/p38-C/EBP-beta cascade via the LQQLL motif of Vpr PubMed
vpr HIV-1 Vpr-induced IL-6 production depends on the activation of NFkappaB and the involvement of C/EBP-beta, TLR4, and MyD88 PubMed
vpr Upregulation of IL-6, IL-10, TNFalpha, and gamma interferon is linked to HIV-1 Vpr activation of NF-IL-6 PubMed
vpr HIV-1 Vpr activates NF-IL-6 resulting in an increase in IL-8 expression and IL-8 promoter activity and also increases transcription of NF-IL-6 enhancer-containing viral promoters PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC32080

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
RNA polymerase II core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
glucocorticoid receptor binding IEA
Inferred from Electronic Annotation
more info
 
histone acetyltransferase binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity NAS
Non-traceable Author Statement
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-like protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acute-phase response TAS
Traceable Author Statement
more info
PubMed 
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
hepatocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
Traceable Author Statement
more info
PubMed 
liver regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
mammary gland epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
mammary gland epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
ovarian follicle development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of biomineral tissue development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of biomineral tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-4 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sodium-dependent phosphate transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sodium-dependent phosphate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of interleukin-6 biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of odontoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription involved in cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
CHOP-C/EBP complex NAS
Non-traceable Author Statement
more info
PubMed 
condensed chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CCAAT/enhancer-binding protein beta
Names
CCAAT/enhancer binding protein (C/EBP), beta
interleukin 6-dependent DNA-binding protein
nuclear factor NF-IL6
nuclear factor of interleukin 6
transcription factor 5
transcription factor C/EBP beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029019.1 RefSeqGene

    Range
    4745..6852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001285878.1NP_001272807.1  CCAAT/enhancer-binding protein beta isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform [b, also known as LAP (liver activating protein)] represented in this RefSeq results from translation initiation at a downstream AUG start codon. Isoform b has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AW025406, BC007538, DB457615
    UniProtKB/Swiss-Prot
    P17676
    Conserved Domains (1) summary
    cd14712
    Location:241311
    bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain
  2. NM_001285879.1NP_001272808.1  CCAAT/enhancer-binding protein beta isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform [c, also known as LIP (liver inhibitory protein)] represented in this RefSeq results from translation initiation at a downstream AUG start codon. Isoform c has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AW025406, BC007538, DB457615
    UniProtKB/Swiss-Prot
    P17676
    Conserved Domains (1) summary
    cd14712
    Location:66136
    bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain
  3. NM_005194.3NP_005185.2  CCAAT/enhancer-binding protein beta isoform a

    See identical proteins and their annotated locations for NP_005185.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform (a, also known as LAP*) represented in this RefSeq results from translation initiation at the 5' most AUG start codon and is the longest isoform.
    Source sequence(s)
    AW025406, BC007538, DB457615
    Consensus CDS
    CCDS13429.1
    UniProtKB/Swiss-Prot
    P17676
    Related
    ENSP00000305422.3, ENST00000303004.4
    Conserved Domains (1) summary
    cd14712
    Location:264334
    bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    50190583..50192690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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